Searched for: author%3A%22van+der+Wielen%2C+L.A.M.%22
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Gallego Murillo, Joan Sebastián (author), Iacono, Giulia (author), van der Wielen, L.A.M. (author), van den Akker, Emile (author), von Lindern, Marieke (author), Wahl, S.A. (author)
Transfusion of donor-derived red blood cells (RBCs) is the most common form of cell therapy. Production of transfusion-ready cultured RBCs (cRBCs) is a promising replacement for the current, fully donor-dependent therapy. A single transfusion unit, however, contains 2 × 10<sup>12</sup> RBC, which requires large scale production. Here, we...
journal article 2022
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Ferrari, F.A. (author), Francisco, Malaret (author), Eustace, S.J. (author), Jason, Hallett (author), van der Wielen, L.A.M. (author), Geert-Jan, Witkamp (author), Bruno, Forte Marcus (author)
A systematic study on the physicochemical properties of two protic ionic liquids (ILs) {2-hydroxyethylammonium acetate ([Mea][Ac]) and 2-hydroxyethylammonium hexanoate ([Mea][Hex])} and their mixtures with water was performed. The density and viscosity were assessed across the entire range of aqueous dilutions between 278 and 393 K. The...
journal article 2022
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Palmeros Parada, M.D.M. (author), van der Wielen, L.A.M. (author), Osseweijer, P. (author), van Loosdrecht, Mark C.M. (author), Pashaei Kamali, F. (author), Posada Duque, J.A. (author), van der Putten, Wim H. (author)
Aviation biofuels are promising to reduce carbon emissions in the aviation sector. However, emerging concerns over biofuels indicate a need for sustainability analyses that take into consideration the context around biofuel production. Here, we present a novel ex-ante sustainability analysis of production alternatives for aviation biofuel in...
book chapter 2022
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Palmeros Parada, M.D.M. (author), van der Putten, Wim (author), van der Wielen, L.A.M. (author), Osseweijer, P. (author), van Loosdrecht, Mark C.M. (author), Pashaei Kamali, F. (author), Posada Duque, J.A. (author)
Biobased production has been promoted as an alternative to fossil-based production to mitigate climate change. However, emerging concerns over the sustainability of biobased products have shown that tensions can emerge between different objectives and concerns, like emission reduction targets and food security, and that these are dependent on...
journal article 2021
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van der Wielen, L.A.M. (author), Mussatto, Solange I. (author), van Breugel, J. (author)
Development of affordable and low carbon biobased manufacturing depends critically on strategies that reduce cost and emission profiles. This paper indicates that efforts around the reduction of capital costs by intensification of process equipment need to be carefully weighed against the inherently fast increasing financial and climate costs...
journal article 2021
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Jimenez Gutierrez, J.M. (author), Verlinden, Rob A.J. (author), van der Meer, Peter C. (author), van der Wielen, L.A.M. (author), Straathof, Adrie J.J. (author)
Liquid hot water pretreatment is considered to be a promising method for increaing biomass digestibility due to the moderate operational conditions without chemical additionA necessary step towards the scalability of this pretreatment process is performing pilot plant triaUpscaling was evaluated with a scaling factor of 500, by using 50 mL in...
journal article 2021
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Gelain, L. (author), Geraldo da Cruz Pradella, José (author), Carvalho da Costa, Aline (author), van der Wielen, L.A.M. (author), van Gulik, W.M. (author)
Intracellular metabolites were evaluated during the continuous growth of Trichoderma harzianum P49P11 under carbon-limited conditions. Four different conditions in duplicate were investigated (10 and 20 g/L of glucose, 5.26/5.26 g/L of fructose/glucose and 10 g/L of sucrose in the feed). Differences in the values of some specific...
journal article 2021
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Consorti Bussamra, B. (author), Sietaram, D.L. (author), Verheijen, Peter J.T. (author), Mussatto, Solange (author), Carvalho da Costa, Aline (author), van der Wielen, L.A.M. (author), Ottens, M. (author)
This article provides an analysis on published models used to calculate phase separation in aqueous two-phase systems (ATPS) based on Flory-Huggins (FH) theory, in terms of problem formulation and mathematical solving algorithm. An integrated algorithm is presented, showing different mathematical approaches of using the FH theory. The algorithm...
journal article 2020
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Jimenez Gutierrez, J.M. (author), van der Wielen, L.A.M. (author), Straathof, Adrie J.J. (author)
Pretreatment of lignocellulosic biomass is required for many biorefinery processes. Previous studies have described hydrolysis of hemicelluloses by using liquid hot water (LHW) pretreatment. We evaluated the effect of carbonic acid originating from pressurized carbon dioxide during LHW pretreatment of poplar. The conditions applied covered...
journal article 2020
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Gernat, D.C. (author), Rozenbroek, Renzo (author), Brouwer, Eric R. (author), van der Wielen, L.A.M. (author), Ottens, M. (author)
BACKGROUND: Recently, a new process concept has been proposed to selectively adsorb wort off-flavours, i.e. aldehydes, from alcohol-free beers with hydrophobic zeolites. RESULTS: In this work, we investigated the uptake of a mixture of wort flavour compounds (2-methylpropanal, 2-methylbutanal, 3-methylbutanal, furfural, and methional), from a...
journal article 2020
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Consorti Bussamra, B. (author), Meerman, Paulus (author), Viswanathan, V. (author), Mussatto, Solange I. (author), Carvalho da Costa, Aline (author), van der Wielen, L.A.M. (author), Ottens, M. (author)
The enzymatic conversion of lignocellulosic material to sugars can provide a carbon source for the production of energy (fuels) and a wide range of renewable products. However, the efficiency of this conversion is impaired due to product (sugar) inhibition. Even though several studies investigate how to overcome this challenge, concepts on...
journal article 2020
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Gelain, L. (author), Pabst, Martin (author), da Cruz Pradella, José Geraldo (author), da Costa, Aline Carvalho (author), van der Wielen, L.A.M. (author), van Gulik, W.M. (author)
The wild type strain Trichoderma harzianum was able to synthesize enzymes that can catalyse the hydrolysis of p-nitrophenyl-β-D-glucopyranoside (PNPGase) in glucose-limited chemostat cultures. Fructose/glucose and sucrose conditions provided low levels of PNPGase activity. To investigate whether under these conditions other enzymes were...
journal article 2020
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Gelain, L. (author), Kingma, Esther (author), Geraldo da Cruz Pradella, José (author), Carvalho da Costa, Aline (author), van der Wielen, L.A.M. (author), van Gulik, W.M. (author)
Carbon-limited chemostat cultures were performed using different carbon sources (glucose, 10 and 20 g/L; sucrose, 10 g/L; fructose/glucose, 5.26/5.26 g/L; carboxymethyl cellulose, 10 g/L; and carboxymethyl cellulose/glucose, 5/5 g/L) to verify the capability of the wild type strain Trichoderma harzianum to produce extracellular enzymes. All...
journal article 2020
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Gelain, L. (author), van der Wielen, L.A.M. (author), van Gulik, W.M. (author), da Cruz Pradella, José Geraldo (author), Carvalho da Costa, Aline (author)
Cellulase production can be divided into two steps: growth stage; followed by an induction stage. To develop a mathematical model for the optimization of this strategy, two sets of experiments were performed in batch mode for parameter estimation. One set of experiments was performed to evaluate the influence of glycerol regarding cell growth...
journal article 2020
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Sousa Pires da Costa Basto, R.M. (author), Jiménez, M. (author), Mudde, R.F. (author), van der Wielen, L.A.M. (author), Cuellar Soares, M.C. (author)
Emulsion formation is a major concern when dealing with multiphasic fermentations. Flocculants can be used together with other demulsification techniques to improve oil recovery in multiphasic fermentations. In this paper, the impact of adding flocculants during a multiphasic fermentation with 10 wt% dodecane, to destabilize the broth...
journal article 2020
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Sano Coelho, Renato (author), Cuellar Soares, M.C. (author), Franco, Telma T. (author), van der Wielen, L.A.M. (author)
The use of diesel fuel in crop and transportation operations is responsible for one third of the carbon emissions in sugarcane biorefineries. A possible solution is to replace it with biodiesel from lipids, directly produced from sugarcane by highly productive heterotrophic microalgae. In this study a heterotrophic microalgae biodiesel plant,...
journal article 2020
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Pedraza de la Cuesta, S. (author), Knopper, L. (author), van der Wielen, L.A.M. (author), Cuellar Soares, M.C. (author)
Sesquiterpenes are a group of versatile, 15-carbon molecules with applications ranging from fuels to fine chemicals and pharmaceuticals. When produced by microbial fermentation at laboratory scale, solvents are often employed for reducing product evaporation and enhancing recovery. However, it is not clear whether this approach constitutes a...
journal article 2019
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Saffarionpour, S. (author), de Jong, Tessa F. (author), van der Wielen, L.A.M. (author), Brouwer, Eric (author), Ottens, M. (author)
For simulating an adsorption/elution step for separation and recovery of flavor-active esters in beer in the presence of ethanol at various temperatures, and validating the predicted breakthrough behavior, equilibrium data on concentration of each ester is required. This work evaluates the application of frontal analysis method (FA) for...
journal article 2019
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Pereira, Joana P.C. (author), Overbeek, W.J.M. (author), Gudiño Reyes, N.E. (author), Andres Garcia, E. (author), Kapteijn, F. (author), van der Wielen, L.A.M. (author), Straathof, Adrie J.J. (author)
Biobased 2-butanol offers high potential as biofuel, but its toxicity toward microbial hosts calls for efficient techniques to alleviate product inhibition in fermentation processes. Aiming at the selective recovery of 2-butanol, the feasibility of a process combining in situ vacuum stripping followed by vapor adsorption has been assessed...
journal article 2019
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Consorti Bussamra, B. (author), Gomes, Joana Castro (author), Freitas, Sindelia (author), Mussatto, Solange I. (author), da Costa, Aline Carvalho (author), van der Wielen, L.A.M. (author), Ottens, M. (author)
Aqueous two-phase systems (ATPS) can be applied to enzymatic reactions that are affected by product inhibition. In the biorefinery context, sugars inhibit the cellulolytic enzymes in charge of converting the biomass. Here, we present a strategy to select an ATPS (formed by polymer and salt) that can separate sugar and enzymes. This automated...
journal article 2019
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