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Stein, M.S. (author), Fauß, Micheal (author)We consider the problem of making a quick decision in favor of one of two possible physical signal models while the numerical measurements are acquired by sensing devices featuring minimal digitization complexity. Therefore, the digital data streams available for statistical processing are binary and exhibit temporal and spatial dependencies....journal article 2019
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Prabhakaran, R. (author), Bruna, P.B.R. (author), Bertotti, G. (author), Smeulders, D.M.J. (author)Representing fractures explicitly using a discrete fracture network (DFN) approach is often necessary to model the complex physics that govern thermo-hydro-mechanical-chemical processes (THMC) in porous media. DFNs find applications in modelling geothermal heat recovery, hydrocarbon exploitation, and groundwater flow. It is advantageous to...journal article 2019
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Bikhezar, Fatima (author), de Kruijff, R.M. (author), van der Meer, A.J.G.M. (author), Torrelo Villa, G. (author), van der Pol, Susanne M.A. (author), Becerril Aragon, Gabriel (author), Gasol Garcia, Ana (author), Denkova, A.G. (author), Narayan, Ravi S. (author)Background and purpose: Glioblastoma multiforme (GBM) is the most aggressive subtype of malignant gliomas, with an average survival rate of 15 months after diagnosis. More than 90% of all GBMs have activating mutations in the MAPK/ERK pathway. Recently, we showed the allosteric MEK1/2 inhibitor binimetinib (MEK162) to inhibit cell...journal article 2019
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Plomp, E. (author), Dintzner, N.J.R. (author), Teperek, M. (author), Dunning, Alastair (author)Research data management (RDM) is increasingly important in scholarship. Many researchers are, however, unaware of the benefits of good RDM and unsure about the practical steps they can take to improve their RDM practices. Delft University of Technology (TU Delft) addresses this cultural barrier by appointing Data Stewards at every faculty....journal article 2019
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Ouyang, B. (author), Xing, Yufei (author), Bogaerts, Wim (author), Caro-Schuurman, J. (author)We propose a design method for silicon ring resonators (RRs) with a free spectral range (FSR) insensitive to fabrication variations. Two waveguide-core widths are used in the RR, with opposite signs of the group-index derivative with respect to the width. This results in cancellation of the width-dependent FSR changes. The systematic...journal article 2019
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Valks, B. (author), Arkesteijn, M.H. (author), den Heijer, A.C. (author)Purpose: The purpose of this study is to generate knowledge about the use of smart campus tools to improve the effective and efficient use of campuses. Many universities are facing a challenge in attuning their accommodation to organisational demand. How can universities invest their resources as effectively as possible and not in space that...journal article 2019
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Venuleo, Sara (author), Pokrajac, Dubravka (author), Schleiss, Anton J. (author), Franca, M.J. (author)We present the results of laboratory investigations of continuously-fed density currents that propagate first over a smooth horizontal bed and then over a porous substrate of limited length. Inflow discharge, initial excess density, and substrate porosities are varied. Density measurements, acquired through an image analysis technique, are...journal article 2019
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Contreras, P. S. (author), Ataei Dadavi, I. (author), Speetjens, M. F.M. (author), Kleijn, C.R. (author), Tummers, M.J. (author), Clercx, H. J.H. (author)The present study concerns Lagrangian transport and (chaotic) advection in three-dimensional (3D) flows in cavities under steady and laminar conditions. The main goal is to investigate topological equivalences between flow classes driven by different forcing; streamline patterns and their response to nonlinear effects are examined. To this...journal article 2019
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Huang, Y. (author), van Gelder, P.H.A.J.M. (author)Collision risk measurement is an essential topic for ship collision prevention. Many risk measures, i.e. DCPA/TCPA, etc., decouple the ship traffic into several pairs of ships and then evaluate the risk in each pair. This kind of measurement loses some information of the entire traffic and might include some biases in risk measurement,...journal article 2019
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Integration of elliptical ship domains and velocity obstacles for ship collision candidate detectionChen, P. (author), van Gelder, P.H.A.J.M. (author), Mou, J. M. (author)The maritime shipping industry has been making significant contributions to the development of the regional and global economy. However, maritime accidents and their severe consequences have been posing an incrementing risk to the individuals and societies. It is therefore important to conduct risk analysis on such accidents to support...journal article 2019
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Huis In 't Veld, Pim J. (author), Volkov, V. (author), Stender, Isabelle D. (author), Musacchio, Andrea (author), Dogterom, A.M. (author)Errorless chromosome segregation requires load-bearing attachments of the plus ends of spindle microtubules to chromosome structures named kinetochores. How these end-on kinetochore attachments are established following initial lateral contacts with the microtubule lattice is poorly understood. Two microtubule-binding complexes, the Ndc80 and...journal article 2019
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Gârlea, Ioana C. (author), Dammone, Oliver (author), Alvarado, José (author), Notenboom, Valerie (author), Jia, Yunfei (author), Koenderink, G.H. (author), Aarts, Dirk G.A.L. (author), Lettinga, M. Paul (author), Mulder, Bela M. (author)When a liquid crystal forming particles are confined to a spatial volume with dimensions comparable to that of their own size, they face a complex trade-off between their global tendency to align and the local constraints imposed by the boundary conditions. This interplay may lead to a non-trivial orientational patterns that strongly depend...journal article 2019
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Sapkota, Hitesh (author), Murukannaiah, P.K. (author), Wang, Yi (author)Trust between developers influences the success of open source software (OSS) projects. Although existing research recognizes the importance of trust, there is a lack of an effective and scalable computational method to measure trust in an OSS community. Consequently, OSS project members must rely on subjective inferences based on fragile and...journal article 2019
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Ibrahim, M.S. (author), Fan, J. (author), Yung, Winco K.C. (author), Wu, Zeyu (author), Sun, B. (author)Nowadays, due to the advancement of design and manufacturing technology, there are many consumer products with high reliability. Similarly, the competition in the business sector influences the product development time to become shorter and that makes it difficult for manufacturers to evaluate the reliability of current products before new...journal article 2019
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Ferreira de Brito, B.F. (author), Floor, Boaz (author), Ferranti, L. (author), Alonso-Mora, J. (author)This letter presents a method for local motion planning in unstructured environments with static and moving obstacles, such as humans. Given a reference path and speed, our optimization-based receding-horizon approach computes a local trajectory that minimizes the tracking error while avoiding obstacles. We build on nonlinear model-predictive...journal article 2019
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Giaccardi, Elisa (author)This article discusses how the artifact of Research through Design (RtD) is changing due to data technology. The article firstly reviews the character and role of the prototype in RtD traditions informed by practices of skillful crafting and industrial design manufacturing. It then describes the move of RtD to data-enabled practices to offer a...journal article 2019
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le Coz, C.M.L. (author), van de Giesen, N.C. (author)An ever-increasing number of rainfall estimates is available. They are used in many important applications such as flood/drought monitoring, water management, or climate monitoring. Such data are especially valuable in sub-Saharan Africa, where rainfall has considerable socioeconomic impacts and the gauge and radar networks are sparse. The...journal article 2019
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Burström, Gustav (author), Swamy, A. (author), Spliethoff, Jarich W. (author), Reich, Christian (author), Babic, Drazenko (author), Hendriks, B.H.W. (author), Skulason, Halldor (author), Persson, Oscar (author), Terander, Adrian Elmi (author), Edström, Erik (author)Pedicle screw placement accuracy during spinal fixation surgery varies greatly and severe misplacement has been reported in 1-6.5 % of screws. Diffuse reflectance (DR) spectroscopy has previously been shown to reliably discriminate between tissues in the human body. We postulate that it could be used to discriminate between cancellous and...journal article 2019
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Oliver, Hilary (author), Shin, Matthew (author), Matthews, David (author), Sanders, Oliver (author), Bartholomew, Sadie (author), Clark, Andrew (author), Fitzpatrick, Ben (author), Haren, R. van (author), Hut, R.W. (author), Drost, Niels (author)Complex cycling workflows are fundamental to numerical weather prediction (NWP) and related environmental forecasting systems. Large numbers of jobs are executed at regular intervals to process new data and generate new forecasts. Dependence between these forecast cycles creates a single never-ending workflow, but NWP workflow schedulers have...journal article 2019
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Kuenen, J.G. (author)When looking back and wonder how we did it, I became even more aware of how my wanderings in microbiology are all linked, from the start of my PhD with Hans Veldkamp on sulphur-oxidizing bacteria in chemostats. My interests broadened from obligate chemolithoautotrophic bacteria to facultative organisms and the question about the ecological...journal article 2019