Automatic detection of the region of interest in corneal endothelium images using dense convolutional neural networks

In images of the corneal endothelium (CE) acquired by specular microscopy, endothelial cells are commonly only visible in a part of the image due to varying contrast, mainly caused by challenging imaging conditions as a result of a strongly curved endothelium. In order to estimate the morphometric parameters of the corneal endothelium, the...

GPU-based stochastic-gradient optimization for non-rigid medical image registration in time-critical applications

Currently, non-rigid image registration algorithms are too computationally intensive to use in time-critical applications. Existing implementations that focus on speed typically address this by either parallelization on GPU-hardware, or by introducing methodically novel techniques into CPU-oriented algorithms. Stochastic gradient descent (SGD...

Automatic estimation of retinal nerve fiber bundle orientation in SD-OCT images using a structure-oriented smoothing filter

Optical coherence tomography (OCT) yields high-resolution, three-dimensional images of the retina. A better understanding of retinal nerve fiber bundle (RNFB) trajectories in combination with visual field data may be used for future diagnosis and monitoring of glaucoma. However, manual tracing of these bundles is a tedious task. In this work,...

Laplacian eigenmaps for multimodal groupwise image registration

Multimodal groupwise registration has been of growing interest to the image processing community due to developments in scanner technologies (e.g. multiparametric MRI, DCE-CT or PET-MR) that increased both the number of modalities and number of images under consideration. In this work a novel methodology is presented for multimodal groupwise...

Loosely coupled level sets for retinal layers and drusen segmentation in subjects with dry age-related macular degeneration

Optical coherence tomography (OCT) is used to produce high-resolution three-dimensional images of the retina, which permit the investigation of retinal irregularities. In dry age-related macular degeneration (AMD), a chronic eye disease that causes central vision loss, disruptions such as drusen and changes in retinal layer thicknesses occur...

Improved registration of DCE-MR images of the liver using a prior segmentation of the region of interest

In Dynamic Contrast-Enhanced MRI (DCE-MRI) of the liver, a series of images is acquired over a period of 20 minutes. Due to the patient's breathing, the liver is subject to a substantial displacement between acquisitions. Furthermore, due to its location in the abdomen, the liver also undergoes marked deformation. The large deformations...

Multi-voxel algorithm for quantitative bi-exponential MRI T₁ estimation

Quantification of the spin-lattice relaxation time, T₁, of tissues is important for characterization of tissues in clinical magnetic resonance imaging (MRI). In T₁ mapping, T₁ values are estimated from a set of T₁-weighted MRI images. Due to the limited spatial resolution of the T₁...