Searched for: contributor%3A%22Dekker%2C+C.+%28promotor%29%22
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Mantel, O.C. (author)
doctoral thesis 1999
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Venema, L.C. (author)
doctoral thesis 2000
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Postma, H.W.Ch. (author)
In this thesis Postma presents transport experiments performed on individual single-wall carbon nanotubes. Carbon nanotubes are molecules entirely made of carbon atoms. The electronic properties are determined by the exact symmetry of the nanotube lattice, resulting in either metallic or semiconducting behaviour. Due to their small diameter,...
doctoral thesis 2001
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Janssen, J.W. (author)
Carbon nanotubes are small cylindrical molecules with a typical diameter of 1 nm and lengths of up to micrometers. These intriguing molecules exhibit, depending on the exact atomic structure, either semiconducting or metallic behavior. This makes them ideal candidates for possible future molecular electronics. In this thesis Janssen describes...
doctoral thesis 2001
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Storm, A.J. (author)
This thesis describes the fabrication and use of nanostructures to study the physical properties of individual DNA molecules. We report DNA translocation experiments through solid-state nanopores with a diameter of about 10 nm. DNA ranging in length from 2000 to 48000 base pairs was detected and we find that the translocation time scales as a...
doctoral thesis 2004
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van der Heyden, F.H.J. (author)
The nanoscale represents a fundamentally new regime for lab-on-a-chip type fluidic systems, because it is the typical length scale across which electrostatic forces are mediated. To understand how ionic liquids and charged objects can be manipulated in nanofluidic devices, a fundamental understanding about the structure of the electrostatic...
doctoral thesis 2006
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Besteman, K. (author)
Screening of charged particles by mobile ions in electrolytes is a major focus of such diverse fields as polymer physics, nanofluidics, colloid science, and biophysics. Yet the physics often remains poorly understood. Here we focus on two counterintuitive phenomena induced by multivalent counterions: charge inversion and DNA condensation.
doctoral thesis 2006
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Koster, D.A. (author)
doctoral thesis 2007
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Van den Heuvel, M.G.L. (author)
This thesis describes experimental work at the interface of nanotechnology and biology. We combine fabrication techniques from nanotechnology with motor proteins from the biological cell. Motor proteins are fascinating protein complexes with nanometer dimensions that are involved in force generation and motion inside cells. One intriguing...
doctoral thesis 2007
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van der Heijden, A.H. (author)
What happens when your DNA breaks? This thesis describes experimental work on the single-molecule level focusing on the interaction between DNA and DNA-repair proteins, in particular bacterial RecA and human Rad51, involved in homologous recombination. Homologous recombination and its central event of DNA strand exchange are essential processes...
doctoral thesis 2007
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Smeets, R.M.M. (author)
This thesis describes experimental work on a novel type of devices capable of detecting single-(bio)molecules; nanometer-sized pores, or nanopores. Individual nanopores are placed in between two electrolyte-filled liquid compartments and (bio)molecules are electrophoretically driven through them. During passage of a single (bio)molecule the...
doctoral thesis 2008
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Heller, I. (author)
This thesis describes the experimental study of devices based on single carbon nanotubes in the context of (bio)sensing in aqueous solutions. Carbon nanotubes are cylindrical molecules of sp2- carbon, about one nanometer in diameter and typically several micrometers long, which have semiconducting or metallic electronic properties. Nanotube...
doctoral thesis 2009
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Kowalczyk, S.W. (author)
Solid-state nanopores, nanometer-size holes in a thin synthetic membrane, are a versatile tool for the detection and manipulation of charged biomolecules. This thesis describes mostly experimental work on DNA translocation through solid-state nanopores, which we study at the single-molecule level. In particular, we demonstrate length-wise ...
doctoral thesis 2011
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Van Loenhout, M.T.J. (author)
This thesis describes a series of single-molecule experiments aimed at understanding the physical properties of DNA itself and the proteins that interact with it. We developed and applied sensitive techniques that allowed us to directly probe the conformation and interactions of individual DNA molecules and proteins. Magnetic and optical...
doctoral thesis 2012
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Vlijm, R. (author)
The main focus of this thesis is a better understanding of the basic compaction mechanism of our DNA using multiple single-molecule techniques. The stretched-out length of our DNA is enormous compared with the dimensions of a cell. To make DNA fit within a cell it is systematically wrapped around proteins (histone octamers), forming nucleosomes....
doctoral thesis 2014
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Hol, F.J.H. (author)
In this thesis, I describe experiments aimed at understanding bacterial population dynamics in ecosystems that are spatially structured at the micro-scale. We combine microfabrication and microfluidics to create synthetic ecosystems that have a complex yet well-defined geometry and chemical composition. Bacteria that inhabit such ecosystems can...
doctoral thesis 2014
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Plesa, C. (author)
Solid-state nanopores are small nanometer-scale holes in thin membranes. When used to separate two chambers containing salt solution, any biomolecule passing from one chamber to the other is forced to pass through the pore constriction. An electric field applied across the membrane is used to create an ionic current and electrophoretically drive...
doctoral thesis 2015
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Wu, F. (author)
One of the most basic features that pervade biology is the existence of boundaries that separate living cells from their outer environments. Molecules responsible for the internal organization of a living cell must adapt to its boundaries, as the cell grows, divides, and changes in shape and size. In this thesis, we aim to understand how...
doctoral thesis 2015
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Ganji, M. (author)
doctoral thesis 2016
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van Ginkel, H.G.T.M. (author)
Proteins belong to the most important molecules in living organisms. They function as messengers, transporters and catalysts, and provide cells and tissues with structure. The expression profile of proteins is rich in information, which can be used, for example, in diagnosing diseases. Therefore proteomics, the large scale study of proteins, can...
doctoral thesis 2016
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