Design and prototype of an electrode array for biventricular electrophysiological mapping: An 3D printed electrode array that minimally interferes with cardiac function

Disturbances in the propagation of the electrical wavefront can cause cardiac arrhythmia’s that can, in extreme cases, lead to cardiac arrest. By recording the electrical signals of the heart, a better understanding can be gained of the mechanisms behind cardiac arrhythmias. A method that can be used to investigate the state of the heart is...

Towards CMUT for Neurostimulation: The Development of an Experimental Model for the Validation of Ultrasound Neuromodulation and Back-side Vent Etching for Low-Frequency CMUT Devices

Ultrasound (US) neurostimulation, the non-pharmacological, reversible excitation or inhibition of the nervous system using ultrasonic waves, is emerging as a high interest topic in neurostimulation research. In the current project, an attempt was made to demonstrate US neuromodulation in a Lumbricus Terrestris model of evoked compound action...

Noninvasive Hemodynamic Monitoring: Left Ventricular Pressure-Volume Loop Reconstruction

Heart disease - already a leading cause of death in industrialized societies - is becoming more and more prevalent as society ages. With this increase, improvements in diagnosis and monitoring of heart disease are necessary. Current state-of-theart cardiac assessment techniques are invasive and too strenuous for heart disease patients. Therefore...

High Density Integrated Capacitors for Smart Catheters and Implants

The Flex-to-Rigid (F2R) technology platform is an interconnect platform to integrate heterogeneous electronic systems and devices onto a partially flexible chip for minimally invasive medical instruments. This technology platform allows for the integration of micro electro-mechanical systems (MEMS) and integrated circuits (IC) on a chip in a...

Optimization of microporous PDMS membranes for Organ-on-Chip devices

Organ-on-chip (OOC) devices are micro-engineered three-dimensional (3D) biomimetic systems that can be used to create in vitro models of human tissue. They provide an alternative for conventional cell culture tools in pharmaceutical R&D. Moreover, these devices can contribute in research focused on understanding complex disease processes....

Fabrication and Reliability Study of Parylene-Ceramic Based Flexible Interconnects For Implantable Devices

The Flex-to-Rigid (F2R) platform is a generic IC-based technology platform that allows flexible sensors and electronics to be fabricated and integrated onto the catheters or guidewires of minimally invasive medical instruments. In this thesis, a process flow was developed for the fabrication of flexible metal interconnects based on the F2R...

Flexible parylene-platinum based electrodes and interconnects

F2R is a generic IC fabrication based platform that allows for the fabrication of miniature and flexible sensing functionalities for minimally invasive medical instruments. Examples of these minimally invasive medical instruments are catheters and guidewires. By introducing more materials to the F2R technology, it can be extended to more...

Silicon based device for smart assessment of cellular stiffness

Cellular stiffness plays an important role for several diseases such as atherosclerosis, malaria and cancer. Cellular stiffness can be derived by the velocity of a cell that is squeezed through a constriction channel. For example, a rigid cell will move slowly through the constriction channel and vice versa. In this research a microfluidic...

Irreversible bonding between PI and PDMS for flexible body patches