"uuid","repository link","title","author","contributor","publication year","abstract","subject topic","language","publication type","publisher","isbn","issn","patent","patent status","bibliographic note","access restriction","embargo date","faculty","department","research group","programme","project","coordinates" "uuid:e06f218d-b22b-410c-8041-3199ff0acdaa","http://resolver.tudelft.nl/uuid:e06f218d-b22b-410c-8041-3199ff0acdaa","Long-term Effect of MPH on White Matter Tracts of Adults with ADHD: An Application of Consistent Model Selection followed by TBSS","Wu, Yulun (TU Delft Applied Sciences)","Vos, Frans (mentor); Filatova, Lena (graduation committee); Delft University of Technology (degree granting institution)","2018","We focused on analysis of long-term medication influenced white matter tracts based on diffusion-weighted MRI brain images of patients with ADHD disorder. We applied a framework of consistent model selection with Tract-based spatial statistics (TBSS) to give proper and consistent modelling of fiber-crossing in white matter. An orientation atlas was constructed to give an `orientation prior' during the ball-and-2sticks model estimation. Consistent metrics of fiber properties were obtained for each subject and thus statistical power in crossing-fiber region was improved. Besides, we improved this pipeline by optimising orientation prior and by integrating a high-dimensional image registration.","diffusion MRI; DTI; model selection; ADHD disorder; white matter","en","master thesis","","","","","","","","","","","","Applied Physics","",""