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van de Gevel, Sophie (author)
Liver transplantation remains the only definite cure for end-stage liver disease, yet the demand for donor livers far surpasses their supply, resulting in substantial wait-list mortality rates. This has led to the exploration of extended criteria donor (ECD) livers, which often exhibit compromised function and susceptibility to post...
master thesis 2023
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Bosma, Jooske (author)
Surface micro- and nanotopographies have shown potential in inducing osteogenic differentiation. Titanium nanopillars can enhance osteogenic differentiation of human mesenchymal stromal cells (hMSCs). While the exact mechanisms by which osteogenic differentiation is induced remain unclear, mechanotransduction is thought to play an important role...
master thesis 2023
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Schilder, Amaya (author)
Due to the limited availability of suitable livers for transplantation and the increasing use of suboptimal donor livers, which are more prone to ischemia-reperfusion injury (IRI), there is an urgent need for novel graft-ameliorating therapies. The promising capacities of (liver-derived) mesenchymal stromal cells ((L-)MSC) in mitigating IRI and...
master thesis 2023
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Tao, Lucy (author)
Vascularisation is a critical factor in large-scale tissue engineering, as it supports the survival of cells in large tissue constructs. In native tissue, a hierarchical vascular network is present where larger vessels transport nutrients and oxygen throughout the body, and smaller capillaries facilitate blood-tissue exchange. In large-scale...
master thesis 2023
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van Beek, Marije (author)
Cholangiocarcinoma (CCA) is a rare but aggressive type of primary liver cancer with a dismal prognosis. CCA commonly metastasizes to the lungs and lymph nodes, significantly reducing overall survival. However, a mechanistic understanding of how CCA invades these metastatic sites remains lacking. This is partly due to the failure of current...
master thesis 2023
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Tjernshaugen, Aurora (author)
That mechanical properties of the extracellular environment can influence cell behaviour has already been established. Recent studies indicate that human mesenchymal stem cells are affected by the surface curvature of the underlying substrate. However, how meso-scale substrate curvature affects cell behaviour is still not clear. This study...
master thesis 2022
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Vledder, Amária (author)
Delayed healing or non-union of bone fractures are still clinically and economically relevant problems. Bone healing includes pro- and anti-inflammatory phases, which proved crucial for successful healing. Being able to modulate these inflammatory responses could potentially promote bone fracture healing. Dendritic cells play important roles in...
master thesis 2022
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Wagenaar, Kirsten (author)
To this day, liver transplantation is the only effective treatment for end-stage liver failure. Unfortunately, the scarcity of liver donors leads to waitlist mortality, pushing the need for alternative treatment options. In vitro models are essential tools in research on alternatives for transplantation. One of the promising models is the...
master thesis 2021
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Garmendia Urdalleta, Amaia (author)
Background: Despite the considerable development of the field of orthopedic implants in the past century, complications including poor bone ingrowth and implant associated infection (IAI) persist to this day, causing a huge burden to millions of patients and the healthcare systems worldwide. Additive manufacturing (AM) and the subsequent surface...
master thesis 2021
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ROMPOLAS, Dionysios (author)
Studies have shown that pillars of specific dimensions and spatial arrangement can promote osteogenic differentiation of stem cells and kill bacteria that cause infections. Other studies have shown that surface curvature can also serve as a mechanical cue to modulate cell behavior. Therefore, the fabrication of pillars on curved surfaces would...
master thesis 2021
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Kalogeropoulou, Maria (author)
Cartilage degeneration is a major cause of chronic disability and its treatment usually involves highly invasive procedures. To address this issue, three-dimensional (3D) bioprinting was introduced as a promising tissue engineering approach. However, the structures fabricated with this method are static and lack the dynamic response of native...
master thesis 2021
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Kingma, Esther (author)
Bioprinting is a promising technique that has the ability to generate complex tissue structures for articular cartilage (AC) repair and regeneration. However, most biomaterials used for bioprinting are incapable of representing the complexity of native extracellular matrix (ECM). In this study, a novel cartilage specific bioink has been...
master thesis 2021
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Berkhout, Willemijn (author)
Three-dimensional (3D) bioprinting studies the initial condition of printed constructs, which makes construct static, and neglects the dynamic changes in natural tissue conformation during tissue repair, disease progression and regeneration processes. Therefore, the concept of four-dimensional (4D) bioprinting has been introduced that allows for...
master thesis 2021
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van Dis, Daniëlle (author)
Purpose: Patients with tracheal lesions that exceed half of the trachea’s total length require a tracheal substitute. Tissue engineering, using either synthetic materials or decellularized tracheal tissue, opens up new possibilities for generating tracheal substitutes. Decellularization, a procedure in which the tissue's...
master thesis 2021
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Eijkel, Dirk (author)
In the last two decades, it has been generally accepted that the interaction between bone and immune cells is critical in the process of bone healing and regeneration. Steering this immune response with the development of biomaterials could lead to implant acceptance in the long term. The understanding of osteoimmunological responses is of high...
master thesis 2021
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Nguyen, Huyen My (author)
Cholangiocarcinoma (CCA) is a highly aggressive biliary tumor with a poor prognosis and limited treatment options. Various critical aspects of CCA development remain unclear. Lately, the dynamic process of epithelial-mesenchymal transition (EMT) was highlighted to play a crucial role in the fundamental mechanism of metastatic dissemination....
master thesis 2021
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Popa, Bogdan (author)
Objectives: With an increasing life expectancy in the western societies and more people practising extreme sports, the demand for orthopaedic implants is set to increase. Orthopaedic implant loosening is one of the main causes of revision surgeries, leading to increases in the costs of patient care and patient dissatisfaction. Better...
master thesis 2020
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Šalandová, Monika (author)
Introduction: Aseptic loosening of an orthopaedic implant due to the unsatisfactory attachment to the bone remains one of the most common reasons for failure of these implants. One of the possible approaches for improving the connection between the implanted biomaterial and the bone tissue being formed is the incorporation of bioactive agents...
master thesis 2020
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Tziotziou, Aikaterini (author)
Atherosclerosis is a prevalent cardiovascular disease and defined as plaque formation inside the arterial intima layer. The atherosclerotic plaque is characterized as anisotropic, soft tissue and a potential plaque rupture could result in life-threatening clinical events, such as ischemic attack or stroke. The plaque rupture mechanism is still...
master thesis 2020
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Serra, Sheila (author)
Atherosclerosis is a widespread disease characterized by the formation of a plaque within the inner most layer of the arterial wall. This plaque is comprised of a lipid-rich pool containing little to no collagen covered by a collagenous fibrous cap which serves as a barrier containing the plaque from rupture. Plaque rupture is an often fatal...
master thesis 2020
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