Searched for: contributor:"Fratila-Apachitei, Lidy (mentor)"
(1 - 17 of 17)
document
Lauta, Francesca (author)
The presence of a stem cell source in the epicardium that can be stimulated by exogenous delivery of transforming growth factor-β (TGF-β) and migrate towards the myocardium can represent a new approach to achieve cardiac repair following myocardial infarction. However, injection of drugs always requires use of carriers which help stabilize the...
master thesis 2019
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Tierolf, Melissa (author)
BACKGROUND.Implant-associated infection (IAI) is a rising complication in bone-related medical treatments using metal implants. Preventive measures, such as implant surfaces with integrated antibacterial properties, are hence required. The emergence of antibiotic-resistant pathogens has led to a growing interest in inorganic nanoparticles as...
master thesis 2019
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Visser, Dmitri (author)
With the recent developments in tissue-engineered organ substitutes, there has been an increasing demand for novel culturing techniques to create biological substitutes in vitro, as well as reliable and efficient test methods that can assess their biocompatibility and mechanical performance. In the past two decades, perfusion bioreactors have...
master thesis 2018
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Sarkiri, Maro (author)
Bioengineered skin was initially developed for clinical application in reconstructive surgery, but nowadays it is also considered as a suitable skin model for research. Research applications range from assessment of cosmetic and pharmaceutical products to the modeling of pathological skin conditions. For example, psoriasis is a complicated skin...
master thesis 2018
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Sharma, Abhishek (author)
A major challenge facing the study of bone regeneration today is the inability to mimic the tissue microenvironment and the factors comprising it. Organ-on-chip based microfluidic systems today aim at doing so by dynamically culturing living cells in them. These are preferred owing to their small feature sizes, laminar flows, high throughput,...
master thesis 2018
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Gelderman, Francisca (author)
In the current day and age, osteogenic bone implants are important to reduce healing time and infections after bone implantation. To help induce bone formation, the implant surface can be biofunctionalized with different agents. A promising surface modification technique used to treat titanium implants is Plasma Electrolytic Oxidation (PEO). In...
master thesis 2018
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Honig, Floris (author)
The use of material properties to guide cell behaviour is often utilised in the field of regenerative medicine. Regarding this, surface topography has been shown to control different cellular processes. In nature, topographies exist in a wide variety of shapes, including hierarchical structures with a great degree of surface roughness. Here,...
master thesis 2018
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Razzi, Francesca (author)
Titanium orthopaedic biomaterials to replace degenerated joint surface, improve bone regeneration and fixation are studied and used worldwide. However, not always biomaterial implantation is successful, and the main causes of implant failure remain implant associated infections (IAI) and poor osseointegration. In the recent years, additive...
master thesis 2018
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Fuchs, Dominique (author)
Aseptic loosening is a major cause of revision surgery in total hip arthroplasties. To slow down, or reverse loosening, tissue engineering interventions could provide solutions. One possible solution is collagen crosslinking, increasing the stiffness of the tissue. This research is a first investigation into UV-induced crosslinking on tissue...
master thesis 2018
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de Vries, Anne Mathilde (author)
Currently, the only effective treatment for end-stage liver diseases is liver transplantation. However, the waiting list with patients who are in need of a new liver is long, because too few good-quality donor livers are available. New techniques in the field of tissue engineering are being investigated to create a reconstructed liver, which...
master thesis 2018
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Reinders, Firoz (author)
Bone is a tissue with many important functions, such as structural support, organ protection and mineral homeostasis. Additionally, after trauma, it can naturally regenerate into fresh, fully functional bone tissue. However, several factors can significantly impede the healing process and cause the formation of non-union tissue. Costs for...
master thesis 2018
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Ligeon, M.R.O. (author)
Due to competition of host and bacterial cells to adhere and grow on implant surfaces, implants are frequently associated with a high risk of peri-implant infections. The microorganisms that are abundantly present during peri-implant infections are Staphylococcus bacteria and a variety of other less abundant bacteria as for example Escherichia...
master thesis 2018
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De Witte, Tinke-Marie (author)
In recent years, bone tissue engineering has emerged as a promising strategy to overcome the limitations of current ‘gold standard’ treatment options for bone disorders such as bone autografts and allografts. Bone tissue engineering strategies rely on the development of a scaffold that mimics the extracellular matrix, thereby providing an...
master thesis 2018
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Doekes, Philippine (author)
Plasma membrane dynamics have become increasingly of interest due to recent discoveries on anomalous lipid diffusion in live cells. A specific characteristic has been found in the exponential relation between lateral lipid diffusion and temperature. The finding was reported to be surprising as a linear dependence was theoretically predicted. In...
master thesis 2018
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Widyaratih, Dwisetya Safirna (author)
The presence of implants in the body is frequently associated with a high risk of peri-implant infections. The host and the bacterial cells compete to adhere and grow on the implant surface. Therefore, producing an implant that can promote the stem cells function (e.g., osteogenic differentiation) while reducing bacterial colonization is vital....
master thesis 2017
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Matray, jeffrey (author)
With increasing prevalence of neurodegenerative diseases the need for an effective treatment increases. To date pharmacological treatment is the golden standard. However, the medicines used have many adverse effects and, only work for a short time period. The best solution would be to cure the disease and thus stop the degradation of neurons and...
master thesis 2017
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Zafeiropoulou, Katerina (author)
Degenerative disc disease (DDD) is the accelerated process of intervertebral disc decay (decrease of disc thickness, enhanced cell death, ECM damage and collagen loss etc.), accompanied with pain, as well as structural and functional failure. So far, there are no therapies that can inhibit or even reverse the degenerative progress of this...
master thesis 2017
Searched for: contributor:"Fratila-Apachitei, Lidy (mentor)"
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