Effects of silver nanoparticle- containing 3D printed antibacterial implants on macrophages

Orthopedic implants used for total joint replacements are under a high clinical demand. Although most total joint replacements are successful, premature failures are still affecting tens of thousands of people annually. The major causes of implant failure are aseptic loosening and bacterial infections. To overcome these issues, multifunctional...

Creating a simplified and standardised bioreactor system for tissue-engineered vascular graft culturing and characterisation

With the recent developments in tissue-engineered organ substitutes, there has been an increasing demand for novel culturing techniques to create biological substitutes in vitro, as well as reliable and efficient test methods that can assess their biocompatibility and mechanical performance. In the past two decades, perfusion bioreactors have...

Crosslinking of Peri-Prosthetic Fibrous Membrane: An Exploratory Study

Aseptic loosening is a major cause of revision surgery in total hip arthroplasties. To slow down, or reverse loosening, tissue engineering interventions could provide solutions. One possible solution is collagen crosslinking, increasing the stiffness of the tissue. This research is a first investigation into UV-induced crosslinking on tissue...

Temperature, lipid charge and septin dependence of lateral lipid diffusion in biomimetic membrane systems

Plasma membrane dynamics have become increasingly of interest due to recent discoveries on anomalous lipid diffusion in live cells. A specific characteristic has been found in the exponential relation between lateral lipid diffusion and temperature. The finding was reported to be surprising as a linear dependence was theoretically predicted. In...