Mechanical characterization of thrombi by studying shear and friction: An in vitro study towards a better comprehension of thrombus biomechanics

Stroke, caused by large vessel occlusions, is the second leading cause of death worldwide. Large vessel occlusions are the result of thrombosis, the undesired coagulation of blood within the vasculature. Due to this coagulation, a vessel can get blocked, prohibiting blood flow to areas distal from the occlusion, with all the serious consequences...

Investigating the Relationship Between Clinical Image Characteristics and Mechanical Properties of In Vitro Thrombi in Acute Ischemic Stroke: A Comprehensive Analysis About Acute Ischemic Stroke

Stroke, currently ranked as the second leading cause of mortality and the most prevalent source of enduring disability, imposes significant societal and economic consequences. These consequences encompass the necessity for extended care, rehabilitation, and the economic burdens associated with lost productivity. In the diagnostic process,...

Numerical modeling of aspiration thrombectomy: Utilizing numerical methods for improving the current aspiration catheter

Thrombus Mechanics: The Influence of Fluid Flow on the Microscopic Features and Elasticity of Plasma Thrombi

Abstract - Perfusion impairment of vessels by thrombus formation is the top global cause of death. Depending on the<br/>location and disease pathology, thrombus composition varies, affecting treatment response and making identification of thrombus composition and its mechanical response sought after. The features of a fibrin network, which...

Fingerprinting stain fields in tissue rupture: A conceptual approach: DIC in the diagnosis of atherosclerosis

Atherosclerotic plaque rupture is the underlying cause of 50% of deaths in western society. Although screening methodologies exist, plaques are highly complex, and the parameters used to measure plaque vulnerability are often insufficient for correct medical screening. Since plaque rupture occurs when the vascular forces exceed the plaque...

The association between in vitro human thrombi composition, mechanics, and computed tomography imaging characteristics

<b>Background</b>- A wide variation in composition is found within the thrombi retrieved from acute ischemic stroke patients. The composition of a thrombus and its mechanical properties have a significant influence on the procedural ease and success rate of mechanical retrieval procedures. If the composition and mechanical properties of a...

Development of a computational aspiration thrombectomy model: Application of a two-phase flow approach to describe thrombus behavior

Acute Ischemic Stroke (AIS) is an abrupt onset of a focal neurological deficit due to the occlusion of a cerebral artery caused by thrombosis or embolism. According to the World Health Organization, stroke is the second leading cause of death in the world. One of the available treatments is the aspiration thrombectomy, where a negative pressure...

Pressure induced deformation measurements on atherosclerotic porcine iliac arteries: An MRI study

Aim: Inspect the MRI image sequence to see if it can image the components of an atherosclerotic plaque and investigate if pressure induced deformation measurements can be done on these images. Methods: Four porcine iliac arteries with atherosclerotic plaques were scanned with a T2 imaging sequence in a 7T MRI scanner. One high resolution scan...