Continuous Multimodal Monitoring of Neonates with a Congenital Diaphragmatic Hernia

Introduction: Congenital diaphragmatic hernia (CDH) is a rare developmental defect of the diaphragm characterised by herniation of abdominal organs into the thoracic cavity during prenatal development. This herniation is usually accompanied by pulmonary hypertension (PH) and cardiac dysfunction (CD). Although several parameters are known to...

From CTA to 3D modelling: A computational framework for morphometrical assessment and biomechanical analysis of atherosclerotic carotid arteries

Background: Ischemic stroke is a major cause of death worldwide. Atherosclerosis in the carotid arteries is an established predictor of these events. Ideally, patient-specific prevention plans can be developed that target advanced plaque development prior to events. Morphometry of advanced calcified plaque phenotypes can be assessed through...

A structural and mechanical assessment of thrombus analogs formed under physiological pressure and flow

<b>BACKGROUND - </b>The success of the mechanical thrombectomy treatment in acute ischemic stroke is highly dependent on mechanical clot behavior and characteristics like stiffness. This mechanical treatment is tested in clot analogs. Realistic clot analogs could potentially be made in a realistic formation environment. The effects of blood...

Mechanical and Structural Characterisation of a Calcified Scaffold: Towards the Development of an In-Vitro Model of an Atherosclerotic Fibrous Cap

Atherosclerosis is an inflammatory disease characterised by the formation of plaque in the intimal layer of the artery. The plaque is made of a lipid rich necrotic core which is covered by a collagen rich fibrous cap. If this fibrous cap ruptures, it can lead to sudden thrombotic occlusion of the artery. Rupture of the fibrous cap is linked to...