document

Is the Microcirculation the Key in Understanding the Development of Shock After Cardiothoracic Surgery?

Toet, Rowan (author)

Cardiothoracic surgery is a common treatment for cardiovascular diseases. Patients are admitted to the ICU after cardiothoracic surgery for continuous monitoring to prevent or treat postoperative complications as much and as soon as possible. One of these complications is the development of circulatory shock. It is likely caused by one or a...

master thesis 2023

document

Sensitivity of a coupled modelling workflow to knee marker displacement: Determining the sensitivity of a coupled modelling workflow to variations in marker data retrieved from gait analysis

Wildöer, David (author)

To better understand and predict osteoarthritis, researchers are developing so-called coupled modelling workflows. Coupled workflows convert data from gait analysis studies to subject-specific tissue mechanical response estimations through the use of musculoskeletal and finite element models. The tissue mechanical response inside the joint is...

master thesis 2022

document

Technical Evaluation of Trabecular Metal Augments and Custom Implants in Severe Acetabular Bone Deficiencies

Barends, Jessica (author)

Introduction: Revision total hip arthroplasty (THA) can be challenging in patients with severe acetabular bone defects and there is no consensus on the preferred reconstruction technique in this population. The aim of this study is to determine the biomechanical differences between Trabecular Metal Acetabular Revision System (TMARS) and Custom...

master thesis 2022

document

Motion and uncertainties management in intensity-modulated proton therapy for cervical cancer

Negenman, Eva (author)

Purpose: Proton therapy has been proposed as an alternative to conventional photon therapy for the treatment of locally advanced cervical cancer (LACC) since these patients experience toxicities. Proton therapy may allow for significant sparing of the organs at risk, reducing the incidence of treatment-related morbidities. The aim of this study...

master thesis 2022

document

Measuring fall risk of the elderly with IMU sensors by developing a Convolutional Neural Network

Claassen, Carlijn (author)

The combination of the high number and the consequences of falls in older adults led to the development of fall risk assessments; non-sensor-based and sensor-based. Multiple studies used ML for older adults' fall risk prediction using raw IMU data. This study's objective was to develop a DL algorithm that predicts the fall risk of people living...

master thesis 2022

document

The Cloud Walker: Performance of a novel prototype of a passive gait orthosis tested by healthy people.

van Hengel, Thomas (author)

Goal: Build and evaluate the first prototype of the Cloud Walker, a passive assistive gait orthosis. Method: The Cloud Walker uses muscles of the upper body to store energy in the springs at the back of the Cloud Walker. This energy can than be used to swing the legs forward. The Cloud Walker was evaluated by 9 healthy participants walking on a...

master thesis 2022

document

Radiostereometric Analysis in Unicompartmental Knee Arthroplasty; An Analysis of Marker Placement

Gevers, Imke (author)

Background: Radiostereometric analysis (RSA) is a technique to assess early migration, which has a predictive value for early failure of unicompartmental knee arthroplasty (UKA). To successfully analyze the RSA images it is important to have a sufficient amount of visiblemarkers with an acceptable three-dimensional distribution.<br/>Objective:...

master thesis 2022

document

Mitigating Neuropathic Pain: From Theory to Practice: Inhibiting Neuroma Pain In­-silico and Measuring Neural Activity In­-vivo

Verzijl, Hubald (author)

<i>Neuropathic pain</i> (NP) affects approximately seven to ten percent of the general population. Seventeen percent of NP patients scored their life as “worse than death”. A myriad of causes may underlie NP, such as stroke or spinal cord injury. Also, damage or disease of the <i>peripheral nervous system</i> (PNS) may result in NP. One of the...

master thesis 2021

document

Three-Dimensional Visualization for Double Outlet Right Ventricle Surgical Planning: 3D Printed Models vs. 3D Virtual Reality Reconstruction: Double outlet right ventricle: A complex three-dimensional problem

Peek, Jet (author)

Objectives: In double outlet right ventricle (DORV) both the pulmonary artery and the aorta originate predominantly from the right ventricle (RV) and a ventricular septum defect (VSD) is present. Each DORV patient requires an individual surgical approach. In complex cases the optimal surgical approach may be difficult to assess based on...

master thesis 2021

document

Towards real-time tumor margin assessment in colorectal liver metastases surgery using near-infrared fluorescence-imaging

Dijkhuis, Tom (author)

Introduction Near-infrared fluorescence (NIRF) imaging is a relatively novel development in colorectal liver metastases (CRLM) surgery which has proven to be an added value for the detection of new lesions and surgical guidance. However, new possibilities of NIRF imaging in CRLM surgery are yet to be explored. The fluorescent rim of indocyanine...

master thesis 2021

document

A MATE for post-stroke gait rehabilitation; design optimization of a minimally actuated tendon-based gait rehabilitation device

Haanen, Bram (author)

Robots can be powerful tools in post-stroke gait rehabilitation. However, state-of-the-art robots are often expensive machines containing rigid links with high inertia. Their expensiveness could limit their availability, and their high inertia reduces transparency, which could hinder rehabilitation progress. These factors raise the need for a...

master thesis 2021

document

Evaluation of the positioning of virtually planned polyetheretherketone patient-specific implants and surgical guides in craniofacial surgery

Nagtegaal, Larissa (author)

Purpose: Patient-specific implants (PSIs) and surgical guides are widely used nowadays for the reconstruction of craniofacial defects. In this research, we quantitatively compared the realised position of craniofacial PSIs with the planned position and we calculated the difference between the realised osteotomy and the planned osteotomy if a...

master thesis 2021

document

User-centered co-development of Artificial Intelligence applications: Towards automated vertebral fracture assessment

Mostert, Marijn (author)

Vertebral fractures are the most common osteoporotic fractures, with a prevalence of 12-20% in Europe, making them a major health problem because of the associated morbidity, mortality and costs. Without adequate treatment, vertebral fractures are often followed by subsequent fractures, leading to further invalidation and deterioration of health...

master thesis 2021

document

The future of interventional cardiology: Machine learning algorithms for solving diagnostic and therapeutic challenges

van der Loo, Wouter (author)

Coronary artery disease (CAD) is one of the leading causes of death and disability worldwide. In CAD, the coronary arteries, that supply the myocardium with oxygen, are narrowed or even blocked by a process called atherosclerosis. Invasive coronary angiography (ICA) is the gold standard for the diagnosis of CAD, as well as for intraprocedural...

master thesis 2021

document

Do the elderly use thigh push off in sit-to-stand to compensate for a lack of stability?: Application of the Stability Basin method to assess the stability of compensatory sit-to-stand strategies in young and elderly participants

Worp, Janna (author)

Due to neuromuscular capacity decline, sit-to-stand, an essential daily life activity, is increasingly difficult to perform for elderly. In practice, elderly frequently use compensatory arm-strategies in sit-to-stand. However, the specific advantages of these compensatory strategies are unclear. The focus of this research is to study the...

master thesis 2021

document

Clinical implementation of adaptive intensity-modulated proton therapy (aIMPT) for locally advanced cervical cancer (LACC)

Corbeau, Anouk (author)

Each year, more than 800 women in the Netherlands are diagnosed with cervical cancer, of which approximately half have locally advanced disease. The standard treatment for locally advanced cervical cancer (LACC) is external beam radiotherapy (EBRT) with concurrent chemotherapy followed by brachytherapy. Many patients experience some degree of...

master thesis 2021

document

Quantification of postural stability in the healthy population as reference for future research on Dorsal Root Ganglion stimulation in Spinal Cord Injury patients

Dumas, Josephine (author)

Introduction: Dorsal-Root-Ganglion (DRG) stimulation has been proposed as a neuromodulatory strategy in spinal cord injury (SCI) patients for the recovery of their impaired postural stability. A detailed evaluation of DRG stimulation-induced effects on postural stability can be obtained by recording center of pressure (CoP) and muscle activity...

master thesis 2021

document

The future of fracture management: Feasibility of in-house design, production and implementation of 3D printed wrist casts for the treatment of distal radius fractures

Mooij, Charlotte (author)

INTRODUCTIOND istal radius fractures are traditionally treated with plaster casts. Although this has been the gold standard for treatment for years, it also comes with disadvantages. These are the weight, not being water-resistant and a lack of ventilation, leading to skin problems, itching and compromised hygiene. Furthermore, plaster has no...

master thesis 2021

document

Accuracy of Positioning Custom Triflange Acetabular Components in THA Revision and Tumor Resection Surgery – A 3D-CT Assessment Stud

Meurs, Willemijne (author)

Introduction In recent years, there has been an increasing interest in custom triflange acetabular components (CTAC) for revision and oncological surgery. The aim of this study was to evaluate the surgical accuracy of positioning CTACs in patients receiving either total hip arthroplasty (THA) revision or tumor resection surgery, using a novel 3D...

master thesis 2021

document

Magnetoencephalography to Image the Acute Modulation of Brain Activity by Spinal Cord Stimulation Treatment in Chronic Pain Patients

Ottenheym, Lucas (author)

Background: Spinal cord stimulation (SCS) is a last resort therapy for chronic pain syndromes, of which the exact mechanisms of action remain unknown. Although often effective, not all patients have sufficient pain reduction after implantation. Objective: Analyse the acute effects of tonic and burst SCS on spectral features in the whole brain...

master thesis 2021