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Association between the macrocirculation and the mitochondrial oxygenation in critically ill patients with sepsis

Brouwer, Fleur (author)

IntroductionThe Cellular Oxygen METabolism (COMET) monitor measures mitochondrial oxygentension (mitoPO2) in vivo at the bedside with delayed fluorescence ofmitochondrial protoporphyrin (PpIX). Blocking microcirculatory oxygen supply bypressing the measurement probe on the skin allows the measurement of mitochondrialoxygen...

master thesis 2020

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The future of fracture management: Feasibility of in-house design, production and implementation of 3D printed wrist casts for the treatment of distal radius fractures

Mooij, Charlotte (author)

INTRODUCTIOND istal radius fractures are traditionally treated with plaster casts. Although this has been the gold standard for treatment for years, it also comes with disadvantages. These are the weight, not being water-resistant and a lack of ventilation, leading to skin problems, itching and compromised hygiene. Furthermore, plaster has no...

master thesis 2021

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A MATE for post-stroke gait rehabilitation; design optimization of a minimally actuated tendon-based gait rehabilitation device

Haanen, Bram (author)

Robots can be powerful tools in post-stroke gait rehabilitation. However, state-of-the-art robots are often expensive machines containing rigid links with high inertia. Their expensiveness could limit their availability, and their high inertia reduces transparency, which could hinder rehabilitation progress. These factors raise the need for a...

master thesis 2021

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Magnetoencephalography to Image the Acute Modulation of Brain Activity by Spinal Cord Stimulation Treatment in Chronic Pain Patients

Ottenheym, Lucas (author)

Background: Spinal cord stimulation (SCS) is a last resort therapy for chronic pain syndromes, of which the exact mechanisms of action remain unknown. Although often effective, not all patients have sufficient pain reduction after implantation. Objective: Analyse the acute effects of tonic and burst SCS on spectral features in the whole brain...

master thesis 2021

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Predicting Intensive Care Unit Readmission: Performance and Explainability of Machine Learning Algorithms

van der Meijden, Siri (author)

Intensive Care Unit (ICU) readmission is a serious adverse event associated with high mortality rates and costs. Prediction of ICU readmission could support physicians in their decision to discharge patients from the ICU to lower care wards. Due to increasing ICU data availability, Artificial Intelligence (AI) models in the form of machine...

master thesis 2021

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Invasive Coronary Artery Imaging Using Optical Coherence Tomography: A Cost-effectiveness and Implementation Process Analysis

Oosterveer, Timo (author)

The aim of this project was the implementation of optical coherence tomography (OCT), an invasive intracoronary imaging (ICI) tool used for the visualization of coronary arteries. The implementation was performed in a structured manner by: (1) A literature review into the current applications of OCT in relation to current standards; (2) A thesis...

master thesis 2020

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Towards real-time tumor margin assessment in colorectal liver metastases surgery using near-infrared fluorescence-imaging

Dijkhuis, Tom (author)

Introduction Near-infrared fluorescence (NIRF) imaging is a relatively novel development in colorectal liver metastases (CRLM) surgery which has proven to be an added value for the detection of new lesions and surgical guidance. However, new possibilities of NIRF imaging in CRLM surgery are yet to be explored. The fluorescent rim of indocyanine...

master thesis 2021

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Design of an external patient specific guide for drilling a tunnel through the scaphoid

Hiemstra, Olivier (author)

In recent years, patient specific instrumentation (PSI) has shown to be a promising application of 3D printing in orthopedic surgery. By aiding the surgeon with accurate placement of instruments such as saws or drills, surgeries can be performed faster, and require less surgeon experience. While most of these devices interface directly with the...

master thesis 2020

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How does increased medio-lateral trunk movement affect total system work and the work of ankle joints?

Boers, Lars (author)

Pathologiessuch as stroke or cerebral palsy are often characterized by excessivemediolateral bending of the trunk. However, it is unclear how mediolateral trunk-sway affects mechanicalwork of more distal joints during gait. We therefore pose the researchquestion: <b>How does increased mediolateraltrunk-sway affect the total...

master thesis 2020

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Weight classification during actively assisted elbow flexion and extension

Heyns, Kirsten (author)

Severe muscle weakness is a symptom appearing in certain neuromuscular diseases (NMDs), such as Duchenne Muscular Dystrophy (DMD), affecting people's daily lives by reducing functionality, decreasing independence, and reducing the ability to perform essential daily activities. This patient group might benefit from using active-assistive devices...

master thesis 2023

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Clinical implementation of adaptive intensity-modulated proton therapy (aIMPT) for locally advanced cervical cancer (LACC)

Corbeau, Anouk (author)

Each year, more than 800 women in the Netherlands are diagnosed with cervical cancer, of which approximately half have locally advanced disease. The standard treatment for locally advanced cervical cancer (LACC) is external beam radiotherapy (EBRT) with concurrent chemotherapy followed by brachytherapy. Many patients experience some degree of...

master thesis 2021

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Motion and uncertainties management in intensity-modulated proton therapy for cervical cancer

Negenman, Eva (author)

Purpose: Proton therapy has been proposed as an alternative to conventional photon therapy for the treatment of locally advanced cervical cancer (LACC) since these patients experience toxicities. Proton therapy may allow for significant sparing of the organs at risk, reducing the incidence of treatment-related morbidities. The aim of this study...

master thesis 2022

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Understanding Tooth Removal Procedures using Feature Engineering and Classification Models

de Graaf, Willem (author)

Tooth removal is one of the most performed surgical procedures worldwide. Despite the high amount of tooth removal procedures carried out each year, scientific understanding of these procedures is not present. Knowledge of force and torque behaviour is limited and knowledge about movements has never been subject to scientific research before....

master thesis 2020

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Technical Evaluation of Trabecular Metal Augments and Custom Implants in Severe Acetabular Bone Deficiencies

Barends, Jessica (author)

Introduction: Revision total hip arthroplasty (THA) can be challenging in patients with severe acetabular bone defects and there is no consensus on the preferred reconstruction technique in this population. The aim of this study is to determine the biomechanical differences between Trabecular Metal Acetabular Revision System (TMARS) and Custom...

master thesis 2022

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Measuring fall risk of the elderly with IMU sensors by developing a Convolutional Neural Network

Claassen, Carlijn (author)

The combination of the high number and the consequences of falls in older adults led to the development of fall risk assessments; non-sensor-based and sensor-based. Multiple studies used ML for older adults' fall risk prediction using raw IMU data. This study's objective was to develop a DL algorithm that predicts the fall risk of people living...

master thesis 2022

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Sensitivity of a coupled modelling workflow to knee marker displacement: Determining the sensitivity of a coupled modelling workflow to variations in marker data retrieved from gait analysis

Wildöer, David (author)

To better understand and predict osteoarthritis, researchers are developing so-called coupled modelling workflows. Coupled workflows convert data from gait analysis studies to subject-specific tissue mechanical response estimations through the use of musculoskeletal and finite element models. The tissue mechanical response inside the joint is...

master thesis 2022

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Accuracy of Positioning Custom Triflange Acetabular Components in THA Revision and Tumor Resection Surgery – A 3D-CT Assessment Stud

Meurs, Willemijne (author)

Introduction In recent years, there has been an increasing interest in custom triflange acetabular components (CTAC) for revision and oncological surgery. The aim of this study was to evaluate the surgical accuracy of positioning CTACs in patients receiving either total hip arthroplasty (THA) revision or tumor resection surgery, using a novel 3D...

master thesis 2021

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The Way to Success: Oxygen Consumption (VO2), Effort and Weaning in Mechanically Ventilated Patients in the Intensive Care Unit

Smits, Floor (author)

Critically ill, mechanically ventilated patients require a substantial amount of energy to meet their basic metabolic demands, as well as for their recovery, spontaneous breathing, gaining of strength, and weaning from the ventilator. It is important for patients to use their energy as efficient as possible at all stages of the disease and...

master thesis 2023

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A newly developed 3D-printed porous titanium vertebral body implant for osteoporotic vertebral compression fractures: A proof of principle

Willemse, Kirsten (author)

The incidence of osteoporotic vertebral compression fractures (VCFs) is rapidly increasing, necessitating the identification of the most appropriate treatment method. The well-established first and second generation surgical procedures are not capable of giving optimal outcomes. Moreover, my literature study has shown little to no improvements...

master thesis 2020

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Three-Dimensional Visualization for Double Outlet Right Ventricle Surgical Planning: 3D Printed Models vs. 3D Virtual Reality Reconstruction: Double outlet right ventricle: A complex three-dimensional problem

Peek, Jet (author)

Objectives: In double outlet right ventricle (DORV) both the pulmonary artery and the aorta originate predominantly from the right ventricle (RV) and a ventricular septum defect (VSD) is present. Each DORV patient requires an individual surgical approach. In complex cases the optimal surgical approach may be difficult to assess based on...

master thesis 2021