Analyzing dynamic functional connectivity using state-space models on mice fUS data

In recent years, the increase in brain research led to the development of large-scale brain imaging techniques. With large-scale brain imaging techniques, such as functional magnetic resonance imaging (fMRI), functional connectivity analyses have shown altered connectivity patterns in humans and mice with neurobiological disorders, such as...

Analyzing Functional Ultra- sound Images of the Brain Using Tensor Decompositions

Functional ultrasound (fUS) is a neuroimaging modality that offers high spatial and temporal resolution while also providing portability. In this thesis, neuroimaging data acquired with fUS at Center for Ultrasound and Brain imaging at Erasmus MC (CUBE) is processed. Due to the fact that fUS data is inherently multidimensional, we propose using...

Differentiating Task-Based Functional Ultrasound Signals via Data-Driven Decompositions

At the Center for Ultrasound and Brain imaging at Erasmus MC in Rotterdam, a mouse's visual cortex had been imaged using the fUS technique. The mouse had been exposed to different visual stimuli. The stimuli varied in position, size, and shape. We investigate how the measured task-based fUS signals differ depending on the visual stimuli...

Investigating brain function and anatomy through ICA-based functional ultrasound imaging

Understanding the hidden organizational principles existing in the human brain was always one of the great challenges in Neuroscience. To uncover the way the brain functions, advancements in the fields of Medical Imaging and Computational Science have been of great importance. Powerful imaging tools, such as functional magnetic resonance imaging...