An Implantable Chip for Time Resolved Fluorescence Detection

Photodynamic therapy (PDT) can be used to treat all kinds of (pre-)malignant and non malignant cells, and has some great advantages in comparison with conventional treatments, like radiotherapy and chemotherapy. To be able to perform PDT one needs three things to be present in a cell: photosensitizer, light of a specific wavelength, and oxygen....

Excitation and readout of a thermally driven time-domain optical coherence tomography system

This system presented in this thesis report will be put into practice in a sensory system for dental drilling. The aim of this system is to provide real-time feedback to the practitioner about the anatomical structure in close vicinity of the drill bit. Therefore, the system has to deal with in vivo, in situ bone tissue, bone tissue within a...

Micromachined lamps for tissue spectroscopy

An implant designed to treat glioblastoma multiforme, GBM, in the brain which makes use of metronomic Photodynamic Therapy (mPDT) is being developed. A device to do spectrography is needed in this implant to monitor the evolution of the treatment. Therefore, the aim of this research is to study the viability of a micromachined lamp to do...

Inductively powered implant for monitoring and application of telemetric metronomic photodynamic therapy

Photodynamic therapy (PDT) is a promising treatment for numerous kinds of cancer. A potential advantage of PDT compared to other cancer treatments like radiotherapy and chemotherapy is its selectivity. PDT is based on a photosensitive substance that is administered to a patient. The substance has selective uptake by cancerous tissue and when...

An optical measurement system for the analysis of bacteria in drain fluid

A post-Colon Surgery Optical Measurement Sensor for Early Detection of Bacteria KEY WORDS: Near-Infrared, Light Emitting Diodes, Photodiode, water absorption. PURPOSE: Bacteria detection after a colon surgery is an essential tool to prevent infection of the patient. With this aim we are developing an efficient miniaturized optical measurement...