Searched for: contributor%3A%22McMillan%2C+D.G.G.+%28copromotor%29%22
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de Jong, S.I. (author)
Alkaliphiles thrive in environments with a pH of 8.5 or above, while maintaining an internal pH closer to neutral. Thus, alkaliphilic microorganisms have a proton gradient inverted with respect to the normal orientation. Intuitively, this would nullify the potential to generate energy via respiration with regularly oriented respiratory chains...
doctoral thesis 2024
Godoy Hernandez, A. (author)
The rise of multi-drug resistant bacterial infections is a worldwide growing concern. Despite being one of the greatest medical advances of the 20th century, classical antibiotics are no longer effective against such organisms. Unfortunately, patients infected with drug-resistant bacteria are more likely to experience worse clinical outcomes, as...
doctoral thesis 2022
Marsden, S.R. (author)
Thiamine diphosphate dependent enzymes are excellent catalysts for the asymmetric synthesis of the α-hydroxyketone (acyloin) structural motif, which is found in many pharmaceuticals and fine chemicals. In chapter 2, variants of transketolase from Saccharomyces cerevisiae were screened for the conversion of aliphatic aldehydes with...
doctoral thesis 2021