Irregular breathing in proton therapy: The effect of irregular breathing on the interplay effect in pencil beam scanning proton therapy

Pencil beam scanning is becoming a more common treatment modality. However, its ability to deal with moving targets is known to be limited, as beam motion and target motion can reinforce each other, deteriorating the planned dose distribution in what is called the interplay effect. Literature concerning breathing motion usually investigates...

Optimal control of combined chemo-radiation therapy treatments for improving cancer care

Combined chemo-radiation treatments are often used to enhance tumor cell kill, with respect to their separate treatments. Currently, chemo-radiation therapy treatments are prescribed as a separately optimized radiotherapy treatment with the addition of a generic chemotherapy regimen. The dosing of the combined therapies is mostly based on...

Gd-PSMA Neutron Capture Therapy: A computational feasibility and method development study