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- van Hoek, W.P.M. (author) doctoral thesis 2000
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- Overkamp, K.M. (author) doctoral thesis 2002
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De Swaaf, M.E. (author)This thesis focuses on the production of docosahexaenoic acid (DHA; 22:6), an w-3 polyunsaturated fatty acid with applications in foods and pharmaceuticals, by Crypthecodinium cohnii. This chloroplastless heterotrophic marine microalga has been studied since the end of the nineteenth century and has been identified as a good producer of DHA. C....doctoral thesis 2003
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- Van Maris, A.J.A. (author) doctoral thesis 2004
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- Jansen, M.L.A. (author) doctoral thesis 2004
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- Boer, V.M. (author) doctoral thesis 2005
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Vuralhan, Z. (author)Saccharomyces cerevisiae is a popular industrial microorganism. It has since long been used in bread, beer and wine making. More recently it is also being applied for heterologous protein production and as a target organism for metabolic engineering. The work presented in this thesis describes how S. cerevisiae may be used as a metabolic...doctoral thesis 2006
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Kuijper, S.M. (author)For various reasons mankind is looking for alternatives for fossil fuels. One of these alternatives is ethanol made from plant biomass. However, the plant material when broken down by hydrolysis into its sugar monomers contains a significant amount of xylose, a 5-carbon-sugar or pentose. Contrary to the sugars with 6 carbon atoms (hexoses) wild...doctoral thesis 2006
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Geertman, J.M.A. (author)Abstract not availabledoctoral thesis 2006
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Tai, S.L. (author)This thesis is a compilation of a four-year PhD project on bakers' yeast (Saccharomyces cerevisiae). Since the entire S. cerevisiae genome sequence became available in 1996, DNA-microarray analysis has become a popular high-information-density tool for analyzing gene expression in this important industrial microorganism and model eukaryote. This...doctoral thesis 2007
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Harris, D.M. (author)With an over 1000-fold improvement in specific productivity since its discovery, penicillin is one of the very successful examples of industrial biotechnology. Although classical strain improvement programmes have been a major contributor to this success, the wish for a more rational approach towards improvements has driven the work described in...doctoral thesis 2008
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- Van den Brink, J. (author) doctoral thesis 2009
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- Abbott, D.A. (author) doctoral thesis 2009
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Hazelwood, L.A. (author)Since the release of the entire genome sequence of the S. cerevisiae laboratory strain S288C in 1996, many functional genomics tools have been introduced in fundamental and application-oriented yeast research. In this thesis, the applicability of functional genomics for the improvement of yeast in beer-related processes is investigated. To this...doctoral thesis 2009
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- Boender-van Dijk, L.G.M. (author) doctoral thesis 2011
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Zelle, R.M. (author)Biotechnological production of chemicals from renewable feedstocks offers a sustainable alternative to petrochemistry. Understanding of the biology of microorganisms and plants is increasing at an unprecedented rate and tools with which these organisms can be engineered for industrial application are becoming ever more powerful. However,...doctoral thesis 2011
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De Kok, S. (author)Metabolic engineering – the improvement of cellular activities by manipulation of enzymatic, transport and regulatory functions of the cell – has enabled the industrial production of a wide variety of biological molecules from renewable resources. Microbial production of fuels and chemicals thereby provides an alternative to oil-based production...doctoral thesis 2012
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Veiga, T. (author)In Chapters 2-5 of this thesis, the applicability of transcriptome analysis to guide metabolic engineering strategies in P. chrysogenum is explored by investigating four cellular processes that are of potential relevance for industrial production of ?-lactam antibiotics: - Regulation of secondary metabolism by the Velvet complex (Chapter 2) -...doctoral thesis 2012
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Huisjes, E.H. (author)The ambition to reduce our current dependence on fossil transportation fuels has driven renewed interest in bioethanol. Pectin-rich feedstocks like sugar beet pulp and citrus peel, which are currently sold as cattle feed, are promising raw materials for the production of bioethanol. This thesis explores the challenges related to the fermentation...doctoral thesis 2013
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Guadalupe Medina, V.G. (author)In its search to decrease the environmental impact of the production of materials and food, and for other socio-economic reasons, mankind has recently taken the first steps into a paradigm shift from a petrochemical-based society to a new, sustainable and to a significant extent bio-based society. In this new scenario, biomass derived from...doctoral thesis 2013