Semi-automated Alpha Angle Computation Based on ZTE MRI to Quantitatively Evaluate CAM Morphology

Introduction: This study developed an open access workflow for semi-automated three dimensional (3D) alpha angle measurement to allow researchers and clinicians to evaluate the 3D degree of cam morphology in a fast and objective manner, regardless of their financial resources.<br/><br/>Method: In the semi-automated workflow geometrical...

Biomechanical loading behaviour of a knee joint distraction device as treatment for osteoarthritis

The development of a computational workflow for the semi-automated construction of patient-specific finite element models of tibial fracture fixation

Introduction: Tibial fracture healing complications occur frequently with reported non-union rates up to 23%. Preoperative patient-specific finite element (FE) modelling of fracture fixation may help to minimize these complications. However, developing such models requires labour-intensive work including (manual) segmentation of bones from...

3D Printed patient-specific surgical guide with a lateral hinge protecting K-wire and a soft tissue protecting sleeve for open wedge high tibial osteotomy: A pilot study

Open Wedge High Tibial Osteotomy (OWHTO) is an extensively used, effective treatment option for medical conditions such as medial knee osteoarthritis and varus malalignment. The current developments in the 3D printing industry facilitated using 3D printed patient-specific guides (PSSGs), making OWHTO a desirable treatment option. Although the...

Development of a motion guidance device for 4D CT scans of the wrist

Sensitivity of a coupled modelling workflow to knee marker displacement: Determining the sensitivity of a coupled modelling workflow to variations in marker data retrieved from gait analysis

To better understand and predict osteoarthritis, researchers are developing so-called coupled modelling workflows. Coupled workflows convert data from gait analysis studies to subject-specific tissue mechanical response estimations through the use of musculoskeletal and finite element models. The tissue mechanical response inside the joint is...

Human Mesenchymal Stem Cell Behaviour on Meso-Scale Substrate Curvature: A Finite Element Analysis of the Effects of Substrate Curvature on Cellular Traction Forces and Morphology

That mechanical properties of the extracellular environment can influence cell behaviour has already been established. Recent studies indicate that human mesenchymal stem cells are affected by the surface curvature of the underlying substrate. However, how meso-scale substrate curvature affects cell behaviour is still not clear. This study...

Static strength analysis of a novel custom triflange acetabular component by experimental testing and finite element modelling

Acetabular component revision surgery in people with severe acetabular bone defect is challenging and associated with higher failure rates compared to primary total hip arthroplasty. This MSc Thesis project aimed to assess the static strength of a novel custom triflange acetabular component (CTAC) by experimental testing and finite element (FE)...

Early Detection of Knee Osteoarthritis using Deep Learning-based MRI Features

Background: Advancements in the field of artificial intelligence have lead to the incorporation of automated algorithms in the analysis of medical images and data. Deep learning algorithms have been applied in muscu- loskeletal research to improve the understanding of osteoarthritis and to assist in disease detection and prognosis. The majority...

Development of crumpled-based meta-biomaterials as bone filling substituents

Bone defects are a common problem in healthcare today. When the damage is too extensive, the human body is not able to heal itself. Different solutions are available, but they all have limitations. Therefore, the search for a solution to overcome these limitations is important. In this theses a way to create a scaffold out of seperate crumpled...

Development of a Workflow for Designing Patient-Specific Mandibular Reconstruction Implants and Predicting their Performance through Experimentally Validated Finite Element Models

Restoration of the normal mandibular form and function is attempted with reconstructive surgery. The current standard procedure to restore continuity defects of the mandible involves free tissue transfer with an autologous bone flap. Even though the success rates are high, several critical drawbacks have been associated with this procedure,...

Design and optimisation of an additively manufactured patient-specific partial mandible reconstruction implant

Additive manufacturing (AM) provides the opportunity for complex porous designs, without the costs depending on batch size. Therefore patient-specific implants can be rapidly manufactured. In clinical practice, reconstruction of the mandible is needed in case of bone tumors or trauma. Part of the mandible is removed and the shape of the missing...