A refocusing mechanism for a laser satellite communication terminal

There is an ever-increasing demand for high data transfer rates. Laser satellite communication is a promising technology which offers high data rates and more secure links than the mature radio frequency (RF) communication. To make a laser communication terminal market viable it must be low size, weight and power (SWaP). The telescope drives the...

Parasite Detection using Hyperspectral Microscopy: Hyperspectral microscopy in Malaria and Schistosoma diagnostics: the approximation and detection of spectral signatures

Parasitic diseases such as malaria remain a mayor burden on global health. One of the biggest challenges still to be overcome is that of inadequate diagnoses. This research explores the opportunities that Hyperspectral Imaging yields in this field. The first goal is to estimate the spectral signature of Malaria parasites in non-stained or Giemsa...

Incremental nonlinear control allocation for an aircraft with distributed electric propulsion: An application to the scaled flight demonstrator

To meet the demanding requirements on the environmental impact of aircraft, radically new aircraft concepts need to be developed. Within the NOVAIR project, Royal Netherlands Aerospace Centre (NLR) tests these new concepts on a Scaled flight demonstrator (SFD). Using an SFD allows for testing of dynamic and flight physical behavior of new...

Using Premodifier for Phase Retrieval Problem

Phase Retrieval Problem is very common and has a lot of applications in fields such as microscope, astronomy, crystallography, optical imaging etc.. In this problem, PSF and the pupil function are given, and the goal is to reconstruct the phase of the object. For camera which has 8 bits color depth, the maximum number of colors that can be...

Design and Control of a Portable AO System: A Continuous Model Based Approach

In the field of Adaptive Optics (AO) a new development has been introduced recently: the Wavefront Sensorless Adaptive Optics (WFSless AO) approach, which only uses camera measurements to optimize image quality and does not use a Shack-Hartman (SH) Wavefront Sensor (WFS) [Booth, 2006, Débarre et al., 2009, Hinnen et al., 2008]. In order to...

Extended Scene Deep Learning Wavefront Sensing for Real Time Image Deconvolution

Ground based telescope imaging suffers from interference from the earth’s atmosphere. Fluctuations in the refractive index of the air delay incoming light randomly, resulting in blurred images. A deconvolution from wavefront sensing system is an adaptive optics system that measures the modes in which the light is corrupted (i.e. the wavefront)...

Automating malaria diagnosis: a machine learning approach: Erythrocyte segmentation and parasite identification in thin blood smear microscopy images using convolutional neural networks

Reliable malaria diagnosis techniques that are suitable for point-of-care testing in high burden areas, are vital for effective treatment and monitoring of the disease. Identification of malaria parasites in Giemsa stained blood slides is currently the most widely accepted technique, but its availability is limited by the need for highly trained...

Towards a single shot holographic diagnosis of Schistosomiasis haematobium

Large scale, highly sensitive and specific diagnostic tools are needed to eliminate the transmission of schistosomiasis. This report expands upon the novel approach from M. Hoeboer and P.M. Nijman. Their Smart Optical Diagnostic Of Schistosomiasis device (SODOS), combining the principles of flow cytometry and digital holography, was able to...

Automating the Diagnosis and Quantification of Urinary Schistosomiasis

Schistosomiasis is a neglected tropical disease (NTD) that affects around a quarter-billion people worldwide. Most of the infected people live in tropical regions, especially in sub-Saharan Africa, where there is limited access to diagnostic and other relevant medical facilities. The current reference standard diagnostic procedure - conventional...

Digital holography integrated with flow cytometry for detection of urinary schistosomiasis

Schistosomiasis is an intravascular infection with major public health consequences in developing countries. It is one of the major Neglected Tropical Diseases with more than 240 million people infected and 800 million people at risk in 2015, mostly in sub-Saharan Africa. It is caused by trematode parasites of the genus Schistosoma, in this...

Development towards a robust low-cost Fourier Ptychographic microscope: For the detection of malaria parasites

This thesis discusses developments towards a low-cost Fourier Ptychographic microscope for label free imaging of malaria parasites.<br/>A review of the morphology and life cycle of malaria and the main diagnostic methods for its detection is followed by an introduction to Fourier Ptychography with emphasis on the underlying imaging principles...

Adaptive Optics with Curvature Wavefront Sensor

When acquiring information using imaging techniques, one wants to achieve the best possible resolution in order to obtain valuable results. In the ideal scenario the size of the smallest resolved object features is limited by the wave properties of light, with a number of techniques developed to overcome this limit. In real life measurements the...