Assessing brain structure and function with diffusion-weighted MRI: Application to stroke

Human brain consists of grey and white matter. Grey matter largely forms the<br/>outer layer of the brain, and is responsible for decision making and functioning<br/>of the human body. Complementary, the white matter (WM) contains the<br/>communication pathways between the grey matter areas. Diffusion-weighted<br/>magnetic resonance imaging ...

Application of Sophisticated Models to Conventional Diffusion-Weighted MRI Data

The brain’s white matter mainly consists of (myelinated) axons that connect different parts of the brain. Diffusion-weighted MRI (DW-MRI) is a technique that is particularly suited to image this white matter. The MRI signal in DW-MRI is sensitized to diffusion of water in the microstructure by introducing strong bipolar gradients in the MRI...

Methods for Dynamic Contrast Enhanced MRI

Dynamic Contrast Enhanced MRI is an important technique to assess the pharmacokinetic properties of tissues. This thesis addresses two major steps necessary for quantitative DCE-MRI: the estimation of the tissue’s T1-time and local B1-field strength, and the estimation of the time-dependent concentration of contrast agent in the blood supply to...

Analysis methods for abdominal imaging: Quantifying Crohn's desease activity