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A Promethean Construct: Formulation of a bioink with human donor-derived liver dECM & liver organoids

Guarnotta, Flora (author)

Liver diseases account for two million deaths worldwide each year, and current treatments are limited. 3D bioprinting is a promising technology, that has recently been investigated to tackle this challenge. However, the cells and hydrogels used for bioprinting are not human-derived and do not replicate the natural <i>in vivo</i> environment. The...

master thesis 2023

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The development of a computational workflow for the semi-automated construction of patient-specific finite element models of tibial fracture fixation

Moolenaar, Jet (author)

Introduction: Tibial fracture healing complications occur frequently with reported non-union rates up to 23%. Preoperative patient-specific finite element (FE) modelling of fracture fixation may help to minimize these complications. However, developing such models requires labour-intensive work including (manual) segmentation of bones from...

master thesis 2023

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Modulating the inflammatory phenotype of monocyte-derived dendritic cells using osmolality in 3D microenvironments

Vledder, Amária (author)

Delayed healing or non-union of bone fractures are still clinically and economically relevant problems. Bone healing includes pro- and anti-inflammatory phases, which proved crucial for successful healing. Being able to modulate these inflammatory responses could potentially promote bone fracture healing. Dendritic cells play important roles in...

master thesis 2022

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Development of crumpled-based meta-biomaterials as bone filling substituents

Fokker, Marike (author)

Bone defects are a common problem in healthcare today. When the damage is too extensive, the human body is not able to heal itself. Different solutions are available, but they all have limitations. Therefore, the search for a solution to overcome these limitations is important. In this theses a way to create a scaffold out of seperate crumpled...

master thesis 2022

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Exploring the mechanical properties of bending- and stretching-dominated metamaterials

Wu, Chu-Hsuan (author)

Nature has always had randomness in many ways. Natural cellular structures, specifically, have used randomized microarchitectures to form mechanically efficient materials, such as wood, sponge, and trabecular bone. Mechanical metamaterials are a class of artificial microarchitected materials designed to carry tensions and compressions with...

master thesis 2022

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A Characterization Method for Hard-Soft Material Interfaces in Structural Optimization

van Houten, Paul (author)

The distribution of multiple materials within a single structure is a strategy that various biological systems rely on to achieve outstanding mechanical performances. These biological examples illustrate the effective utilization of hard rigid and soft flexible materials in particular. The proper composition of such hard-soft materials exceeds...

master thesis 2021

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Property-based functional gradients for biomimetic composites

Veeger, Robin (author)

Functional gradients in hard-soft interfaces are abundant in nature, and we often mimic them to create strong and tough composites. A powerful tool for the designs and fabrication of biomimetic composites is voxel-based multi-material 3D printing. Earlier researches mainly focused on using this technique in the creation of gradients based on...

master thesis 2021

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Evaluation of the osteoimmunomodulatory properties of surface biofunctionalized 3D printed titanium bone implants

Garmendia Urdalleta, Amaia (author)

Background: Despite the considerable development of the field of orthopedic implants in the past century, complications including poor bone ingrowth and implant associated infection (IAI) persist to this day, causing a huge burden to millions of patients and the healthcare systems worldwide. Additive manufacturing (AM) and the subsequent surface...

master thesis 2021

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Use of supercritical carbon dioxide for decellularization of porcine trachea in an attempt to generate a tissue-engineered tracheal substitute

van Dis, Daniëlle (author)

Purpose: Patients with tracheal lesions that exceed half of the trachea’s total length require a tracheal substitute. Tissue engineering, using either synthetic materials or decellularized tracheal tissue, opens up new possibilities for generating tracheal substitutes. Decellularization, a procedure in which the tissue's...

master thesis 2021

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Towards Direct Co-culture Models for Osteoimmunodulatory Studies: An exploratory study on the effects of nanopatterns and shear stress on cellular crosstalk

Eijkel, Dirk (author)

In the last two decades, it has been generally accepted that the interaction between bone and immune cells is critical in the process of bone healing and regeneration. Steering this immune response with the development of biomaterials could lead to implant acceptance in the long term. The understanding of osteoimmunological responses is of high...

master thesis 2021

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Towards cardiovascular stents fabricated by stereolithography

van den Brekel, Thomas (author)

Currently, cardiovascular diseases are the leading cause of death worldwide, and a global ageing population ensures increasing numbers for the foreseeable future. Atherosclerosis, responsible for 80\% of cardiovascular deaths, is nowadays treated with stents, which scaffold the balloon-dilated artery and seals the dissection flaps. In 2016, the...

master thesis 2021

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Establishing In Vitro Organoid-Based Epithelial-Mesenchymal Transition Model in Cholangiocarcinoma Including Tumor Extracellular Environment

Nguyen, Huyen My (author)

Cholangiocarcinoma (CCA) is a highly aggressive biliary tumor with a poor prognosis and limited treatment options. Various critical aspects of CCA development remain unclear. Lately, the dynamic process of epithelial-mesenchymal transition (EMT) was highlighted to play a crucial role in the fundamental mechanism of metastatic dissemination....

master thesis 2021

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Assessing the effects of strontium releasing titanium implants on the behaviour of human umbilical vein endothelial cells

Šalandová, Monika (author)

Introduction: Aseptic loosening of an orthopaedic implant due to the unsatisfactory attachment to the bone remains one of the most common reasons for failure of these implants. One of the possible approaches for improving the connection between the implanted biomaterial and the bone tissue being formed is the incorporation of bioactive agents...

master thesis 2020

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Cell adhesion on 3D printed submicron patterns: a quantitative study

Popa, Bogdan (author)

Objectives: With an increasing life expectancy in the western societies and more people practising extreme sports, the demand for orthopaedic implants is set to increase. Orthopaedic implant loosening is one of the main causes of revision surgeries, leading to increases in the costs of patient care and patient dissatisfaction. Better...

master thesis 2020

document

A Strain Energy Limiter Approach for Atherosclerotic Plaque Rupture Modelling

Tziotziou, Aikaterini (author)

Atherosclerosis is a prevalent cardiovascular disease and defined as plaque formation inside the arterial intima layer. The atherosclerotic plaque is characterized as anisotropic, soft tissue and a potential plaque rupture could result in life-threatening clinical events, such as ischemic attack or stroke. The plaque rupture mechanism is still...

master thesis 2020

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Large bone-implants for osteochondral regeneration, fabrication and ex-vivo testing

Gkoni, Joanna (author)

The high frequency of osteoarthritis in those aged above 60 years combined with the observing trend of overpopulation leads to increased healthcare costs. To date, clinical treatments seem to be insufficient to restore cartilage and underlying bone degeneration. Bioprinting fabrication techniques constitute a promising approach to mimic and...

master thesis 2020

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Shape-shifting of hyperbolic surfaces: Design and analysis of a shape-shifting method for complex hyperbolic surfaces, based on a passive frame in combination with an active shape-memory polymer

Uyttendaele, Raf (author)

Almost every tissue in the human body is curved in a certain way. Examples are the extracellular matrix of different tissues such as trabecular bone, different acini and blood vessels. As such, the ability to create complex curved structures is crucial in the development of biomimetic biomaterials that could be used, for example, for tissue...

master thesis 2020

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Patient-specific Ti dental implants with antimicrobial properties

van Megen, Xandra (author)

Dental implants are used to replace missing teeth. Although the success rate of dental implants is high, complications such as lack of osseointegration and peri-implantitis can occur. In this study a new type of dental implant is designed that mimics the root shape of the to be extracted tooth. These types of implants can be placed directly...

master thesis 2020

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A systematic study of macrophages’ response to submicron pillars

Isaakidou, Katerina (author)

Objective: Advances in the field of biomaterials have positively affected implant acceptance and nowadays nanostructured surfaces are known to have a positive effect on bone regeneration. The development of the field of osteoimmunology has contributed to a steadily increasing interest towards the investigation of the immunomodulatory effect of...

master thesis 2019

document

Unravelling the antibacterial mechanisms of silver, copper and zinc nanoparticles incorporated on titanium bone implants

Grotenhuis, Raisa (author)

Background. The past four decades, the problem of resistant bacteria has emerged. As a result of biofilm formation of (resistant) bacteria on the implant, more implant-associated infections (IAI) occurred. This has caused an increase in orthopaedic implant revisions, causing a high burden of disease. To overcome the rising problem of resistance,...

master thesis 2019