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Zwart, Maarten (author)
Over two million bone grafts are performed worldwide, each year. The preferred method is using autografts, but there are two important downsides. There is often insufficient tissue to harvest and the scar at the harvesting side is painfull for the patient. Therefore there exists a great need to improve synthetic grafts.<br/><br/>Traditionally,...
master thesis 2024
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van Hoften, Roos (author)
master thesis 2023
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Edwin Tay Wei Shen, Edwin (author)
The widespread proliferation of cellular lattices in engineering design has entailed a revolution in the design of lightweight and multifunctional structures. Furthermore, the development of auxetic metamaterials has led to applications in fields ranging from biomedical to civil engineering. However, cellular lattices suffer from the development...
master thesis 2022
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TSIFOUTIS KAZOLIS, Kostas (author)
Mechanical metamaterials are materials that appear to have unusual elastic mechanical properties, with the most prominent being a negative Poisson’s ratio. The key to their unique properties lies in the microarchitecture of the material rather than the material itself. For advanced applications in the realm of prosthetics, such as form matching,...
master thesis 2022
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Troost, Léander (author)
Integration of the sensory systems inside patient-specific medical devices (e.g., implants or prosthesis) can provide additional measurement data at different time points. This can result in improving the traditional designs of those medical devices, and consequently leading to increasing the patient’s comfort and quality of life. By doing...
master thesis 2022
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Veeger, Robin (author)
Functional gradients in hard-soft interfaces are abundant in nature, and we often mimic them to create strong and tough composites. A powerful tool for the designs and fabrication of biomimetic composites is voxel-based multi-material 3D printing. Earlier researches mainly focused on using this technique in the creation of gradients based on...
master thesis 2021
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Wagenaar, Kirsten (author)
To this day, liver transplantation is the only effective treatment for end-stage liver failure. Unfortunately, the scarcity of liver donors leads to waitlist mortality, pushing the need for alternative treatment options. In vitro models are essential tools in research on alternatives for transplantation. One of the promising models is the...
master thesis 2021
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Pitta Kruize, Carlos (author)
The mechanical properties of biological hard-soft interfaces change gradually over a small surface area to prevent the formation of stress concentrations through variations in the interface’s chemical composition, microstructure and geometry. The bone-tendon/ligament and bone-cartilage interface are the most prominent hard-soft interfaces within...
master thesis 2021
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Rutten, Niek (author)
Introduction: A combined bone growth and remodeling model should be created, to investigate the effect of different femur shapes on the risk of developing cam type deformities. The different femur shapes needed for this study can be created using a statistical shape and appearance model (SSAM). The workflow of the combined bone growth and...
master thesis 2021
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ROMPOLAS, Dionysios (author)
Studies have shown that pillars of specific dimensions and spatial arrangement can promote osteogenic differentiation of stem cells and kill bacteria that cause infections. Other studies have shown that surface curvature can also serve as a mechanical cue to modulate cell behavior. Therefore, the fabrication of pillars on curved surfaces would...
master thesis 2021
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Kalogeropoulou, Maria (author)
Cartilage degeneration is a major cause of chronic disability and its treatment usually involves highly invasive procedures. To address this issue, three-dimensional (3D) bioprinting was introduced as a promising tissue engineering approach. However, the structures fabricated with this method are static and lack the dynamic response of native...
master thesis 2021
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Berkhout, Willemijn (author)
Three-dimensional (3D) bioprinting studies the initial condition of printed constructs, which makes construct static, and neglects the dynamic changes in natural tissue conformation during tissue repair, disease progression and regeneration processes. Therefore, the concept of four-dimensional (4D) bioprinting has been introduced that allows for...
master thesis 2021
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van Rijn, Lisa (author)
After en bloc resection of primary pelvic bone tumours, orthopaedic oncologists usually try to perform reconstruction in order to achieve limb salvage. Reconstruction after these types of resections is challenging. Especially when the total ilium and parts of the sacrum needs to be removed. One of the reconstructive options is endoprosthetic...
master thesis 2020
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Serra, Sheila (author)
Atherosclerosis is a widespread disease characterized by the formation of a plaque within the inner most layer of the arterial wall. This plaque is comprised of a lipid-rich pool containing little to no collagen covered by a collagenous fibrous cap which serves as a barrier containing the plaque from rupture. Plaque rupture is an often fatal...
master thesis 2020
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Frints, Ivo (author)
Osteoarthritis, the degeneration of articular cartilage, which causes loss of mobility and chronic pain for patients is a common condition with high clinical demand. Care of this condition currently attributes to ±1.4% of the Dutch annual health care costs, but due to the rapidly aging Dutch population a 41% increase of cases is projected over...
master thesis 2020
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Oldhoff, Miriam (author)
Additive manufacturing (AM) provides the opportunity for complex porous designs, without the costs depending on batch size. Therefore patient-specific implants can be rapidly manufactured. In clinical practice, reconstruction of the mandible is needed in case of bone tumors or trauma. Part of the mandible is removed and the shape of the missing...
master thesis 2019
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Eyisoylu, Hande (author)
Aortic Abdominal Aneurysm (AAA) is a chronic degenerative disease of the arterial wall. The aortic vessel wall abnormally dilates due to multiple possible causes and may eventually rupture. It is characterized by several factors leading to the extreme dilation due to the degeneration of the vessel wall extracellular matrix (ECM). It is often...
master thesis 2019
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Kuliesh, Alina (author)
Triply Periodic Minimal Surfaces (TPMS) have earned great popularity in porous meta- biomaterials by cause of unique mass transfer properties, tunable mechanical properties, large pore space and high surface to volume ratio. Numerical and experimental studies suggest a great potential for TPMS-based architectures in the treatment of segmental...
master thesis 2019
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Kunkels, Lorenzo (author)
Patients with orthopaedic implants often experience implant-associated infections (IAI), one of the most prominent causes for implant failure. IAIs are caused by pathogens adhering to the implant surface. One method to prevent IAIs is through the use of surface topography modifications. Cellular behaviour has been shown to be influenced by...
master thesis 2019
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Gunashekar, Deepthishre (author)
Polymer composites are found to have high performance efficiency because of its highly flexible polymer matrix and stiff fibres or functional fillers. The matrix and the reinforcements are two main components for a strong and tough composite. The performance of these composites highly depend on the material property of the matrix and the...
master thesis 2019
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