Modeling Primary Liver Cancer using Tumor-Derived Extracellular Matrix

Due to the global health impact of primary livercancer, resourceful models are required to develop new therapies and to studychemo-resistance. Recentadvantages in understanding cancer complexity have shifted research to theimportance of the niche of the tumor cells. In cholangiocarcinoma (CCA), anaggressive malignancy of the...

Effects of silver nanoparticle- containing 3D printed antibacterial implants on macrophages

Orthopedic implants used for total joint replacements are under a high clinical demand. Although most total joint replacements are successful, premature failures are still affecting tens of thousands of people annually. The major causes of implant failure are aseptic loosening and bacterial infections. To overcome these issues, multifunctional...

Deformable Acetabular Implants: an explorative study

An acetabular revision is a very challenging intervention, due to moderate to severe bone deficiencies and poor bone quality. Current solutions for this intervention are associated with inconsistent and unreliable clinical outcomes. This leads to substantial complications, including implant migration and loosening. These complications are, among...

Creating a simplified and standardised bioreactor system for tissue-engineered vascular graft culturing and characterisation

With the recent developments in tissue-engineered organ substitutes, there has been an increasing demand for novel culturing techniques to create biological substitutes in vitro, as well as reliable and efficient test methods that can assess their biocompatibility and mechanical performance. In the past two decades, perfusion bioreactors have...

Temperature, lipid charge and septin dependence of lateral lipid diffusion in biomimetic membrane systems

Plasma membrane dynamics have become increasingly of interest due to recent discoveries on anomalous lipid diffusion in live cells. A specific characteristic has been found in the exponential relation between lateral lipid diffusion and temperature. The finding was reported to be surprising as a linear dependence was theoretically predicted. In...

Mechanical properties and deformation behaviour of highly porous pure titanium structures: A first step towards the design of a plastically deformable acetabular implant

Massive acetabular bone defects are difficult to treat with the currently available implants. Advances in additive manufacturing create new design possibilities, which allow the production of patient specific implants. These endless possibilities will enable to tune the mechanical properties of porous implants and to distribute the loads in such...