Searched for: contributor%3A%22de+Kruijff%2C+R.M.+%28mentor%29%22
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van Dijk, Caro (author)
Technetium-99m (<sup>99m</sup>Tc) is a critical isotope in nuclear medicine, used for diagnostic imaging. It is conventionally produced in a aluminum oxide <sup>99</sup>Mo/<sup>99m</sup>Tc generator that runs on molybdenum-99 (<sup>99</sup>Mo) produced by fission of uranium-235. This fission-based production method faces several challenges. To...
bachelor thesis 2024
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Riemersma, Matthijs (author)
<sup>161</sup>Tb is considered a promising alternative to<sup> 177</sup>Lu in the treatment of neuroendocrine tumors and prostate cancer. It is produced via neutron irradiation of <sup>160</sup>Gd targets and its subsequent separation from said targets. Current separation methods have limitations so a fast removal method of the Gd bulk is...
master thesis 2024
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van Heuckelum, Joran (author)
<div>Implant-associated infections by antibiotic-resistant biofilm-forming pathogenic bacteria such as <i>Staphylococcus aureus</i> have become a growing concern as they are difficult to treat and lead to implant revision surgery. Implant coatings consisting of superparamagnetic iron oxide nanoparticles may prevent the attachment to and...
master thesis 2023
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Coffeng, Lotte (author)
Cancer is often treated by radiation therapy. There are three types of radiation therapy: external beam therapy, brachytherapy and radionuclide therapy. A downside to radiation therapy is its damaging effect on healthy tissue. A different type of treatment is photodynamic therapy. In PDT photo-active substances are being used to generate...
bachelor thesis 2023
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Brandwijk, Anouk (author)
Calcium is the most abundant mineral in the human body and is essential for building and maintaining bones and teeth. Only 20-30% of the calcium in milk can be absorbed by the human body. 90% of the insoluble calcium in milk is located in the casein micelles, and 40% of this calcium is hard to exchange.<br/>It is important to understand how this...
master thesis 2023
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Spruit, Esther (author)
Holmium-166 is a promising radionuclide for therapeutic and imaging applications due to its advantageous decay characteristics. However, these applications require or would benefit from a higher specific activity of <sup>166</sup>Ho than that obtained via a <sup>165</sup>Ho(n,γ)<sup>166</sup>Ho reaction by irradiating a pure <sup>165</sup>Ho...
master thesis 2023
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Westerman, Maaike (author)
To ensure proper development, infants must receive the right amount of nutrients. Since their intake of minerals and trace elements in the first four months comes solely from mother milk or formula, valuable information about the uptake can derived by analyzing their excretion (in the form of feces or urine). Previous studies have used this...
master thesis 2022
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Thakoer, Devi (author)
Iron deficiency is considered the most significant nutritional deficiency worldwide, affecting billions of people. Iron deficiency leads to a higher prevalence of iron deficiency anaemia; a condition responsible for over 50,000 deaths annually. Since anaemia is considered a global health problem, various countermeasures have been implemented to...
master thesis 2022
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Sewrattan, Shanin (author)
In the human body calcium is the most abundant mineral and is involved in a lot of vital processes. Calcium deficiency occurs when there is not enough calcium present in the bloodstream. In the Netherlands one in three women will face this problem in their lifetime. A major factor contributing to this problem is that the intake of calcium on...
master thesis 2022
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Berkhout, Joost (author)
Combining different treatment modalities has proven to improve patient outcome compared to applying single treatments. Consequently, mild hyperthermia (HT) and radiotherapy (RT) are combined to radiosensitize tumour cells by inhibiting DNA damage repair mechanisms. In this study, it was investigated if combining both...
master thesis 2022
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van den Elshout, Rebecca (author)
Radiotherapy is a vital component in the treatment of malignancies, with approximately 50 to 70% of cancer patients receiving it at some point. This therapy consists of irradiating the affected body part with an external beam of ionising radiation. A limitation of this technique is its damaging effect on healthy cells surrounding the tumour....
bachelor thesis 2022
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Schenk, Wout (author)
166Ho is a promising radionuclide for targeted radionuclide therapy, because of its beneficial decay characteristics and the possibility to track its dose delivery in a patient. However, a problem for the use of 166Ho in these treatments is its limited maximally produced specific activity in neutron irradiation of a pure 165Ho target, since the...
master thesis 2022
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Bekkema, Bart (author)
Radiometals re-emerge as a promising alternative in nuclear imaging. Cyclotron production of such radiometals using liquid targets solve critical impurity problems seen with current conventional production methods. Purification employing liquid-liquid extraction in microfluidic environments has recently been investigated. Fluid behaviour in...
master thesis 2022
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de Jong, Rémy (author)
Microfluidic extraction is a promising alternative for existing extraction methods of radioisotopes due to the high surface-to-volume ratio. When assessing the compatibility of microfluidic material with the extraction system, there are three critical aspects—compatibility with organic solvents, compatibility with the radiochemistry, and, most...
master thesis 2022
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Kloosterboer, Lisette (author)
Anaemia affects a third of women and almost 50% of infants and toddlers worldwide. Iron deficiency is the most common cause of anaemia, and the most common nutritional disorder in the world. To increase dietary iron intake, iron fortification of staple foods commonly consumed by the general public is an effective approach to prevent and control...
master thesis 2022
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van der Horst, Evie (author)
Calcium is an important mineral which the body uses to maintain strong bones and carry out many important bodily functions. According to the Dutch nutrition center people in the Netherlands consume 80-90% of their calcium through milk and other milk products. Often times people will further ’process’ milk for other food products. Examples of...
bachelor thesis 2021
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de Vos, Marije (author)
Calcium is an important nutrient for both young and elderly people which can, among others, stimulate healthy bone growth and prevent osteoporosis. Therefore, nutrition with sufficient calcium is of great importance. The highest calcium nutrient density for all foods can be found in bovine milk, which contains on average 1.2 g Ca / L. To...
master thesis 2021
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Naaktgeboren, Miranda (author)
Radionuclides are important in the diagnosis and treatment of, amongst others, cancer. A promising therapy is targeted radionuclide therapy, where the radionuclide is brought to the tumor by a targeting specific<br/>vector. Bringing the radionuclide directly to the tumor, should reduce the dose to the healthy tissue. For targeted radionuclide...
master thesis 2021
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