Structured Kinetic Modeling for Rational Scale-down and Design Optimization of Industrial Fermentations

Investigation of Temperature Tolerance in Saccharomyces cerevisiae under Anaerobic Conditions

Saccharomyces yeasts are common workhorses for the production of alcoholic beverage and bio-ethanol. In these production processes, temperature is one of the predominant factors determining the operational costs of the industrial fermentation processes and the quality of the products (alcoholic beverage) because it influences the functioning of...

Uncoupling yeast growth and product formation in chemostat and retentostat cultures

The progress of modern biotechnology has enabled the development of fermentation processes for the production of fuels and chemicals from renewable feedstocks. The current fermentation processes for bio-based production commonly start with a growth phase of the microorganisms followed by a production phase. This implies that biomass formation...

Mathematical modelling of cellulase production and continuous production of enzymes under carbon-limited conditions by Trichoderma harzianum P49P11

Trichoderma harzianum P49P11 was selected among several other microorganisms at the Biorenewables National Laboratory (LNBR, Brazil) and it was considered a promising strain to produce cellulase. Here in this project, a mathematical model and simulation platforms were developed as potential tools to be used for cellulase maximization using fed...

Towards enhanced second-generation n-butanol production from sugarcane

Nowadays, the biotechnology industry is facing the challenge of producing suitable equivalents for petroleum-based products from renewable resources in a sustainable and economically feasible way. Finding cleaner alternatives for gasoline, fuels, and chemicals, has been the subject of research worldwide, whether for economic, geopolitical, or...

Transport processes in the production of organic acids from lignocellulosic feedstocks by Aspergillus niger

Filamentous fungi, especially from the genus Aspergillus, are well known for the<br/>production of organic acids in fermentation industry. Nonetheless, in present time the competing chemical conversion routes are still more profitable, leaving space for further investigations and improvement on the biological routes.

Dicarboxylic acids transport, metabolism and roduction in aerobic Saccharomyces cerevisia

A scale-down study of the industrial penicillin fermentation using quantitative metabolomics