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van de Willige, Dieudonnée (author), Hummel, Jessica J.A. (author), Alkemade, C. (author), Kahn, Olga I. (author), Au, Franco K.C. (author), Qi, Robert Z. (author), Dogterom, A.M. (author), Koenderink, G.H. (author), Hoogenraad, Casper C. (author), Akhmanova, Anna (author)Crosstalk between the actin and microtubule cytoskeletons underlies cellular morphogenesis. Interactions between actin filaments and microtubules are particularly important for establishing the complex polarized morphology of neurons. Here, we characterized the neuronal function of growth arrest-specific 2-like 1 (Gas2L1), a protein that can...journal article 2019
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Aher, Amol (author), Kok, M.W.A. (author), Sharma, Ashwani (author), Rai, Ankit (author), Olieric, Natacha (author), Rodriguez-Garcia, Ruddi (author), Katrukha, Eugene A. (author), Weinert, Tobias (author), Olieric, Vincent (author), Kapitein, Lukas C. (author), Steinmetz, Michel O. (author), Dogterom, A.M. (author), Akhmanova, Anna (author)The dynamic instability of microtubules plays a key role in controlling their organization and function, but the cellular mechanisms regulating this process are poorly understood. Here, we show that cytoplasmic linker-associated proteins (CLASPs) suppress transitions from microtubule growth to shortening, termed catastrophes, including those...journal article 2018
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Tas, Roderick P. (author), Chen, Chiung Yi (author), Katrukha, Eugene A. (author), Vleugel, M. (author), Kok, M.W.A. (author), Dogterom, A.M. (author), Akhmanova, Anna (author), Kapitein, Lukas C. (author)Force generation by molecular motors drives biological processes such as asymmetric cell division and cell migration. Microtubule gliding assays in which surface-immobilized motor proteins drive microtubule propulsion are widely used to study basic motor properties as well as the collective behavior of active self-organized systems....journal article 2018