Searched for: department:"ImPhys%5C%7Eslsh%7EImaging%5C+Physics"
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Ambrosini, P. (author), Hollemans, Eva (author), Kweldam, Charlotte F. (author), Leenders, Geert J.L.H.van (author), Stallinga, S. (author), Vos, F.M. (author)
Cribriform growth patterns in prostate carcinoma are associated with poor prognosis. We aimed to introduce a deep learning method to detect such patterns automatically. To do so, convolutional neural network was trained to detect cribriform growth patterns on 128 prostate needle biopsies. Ensemble learning taking into account other tumor...
journal article 2020
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Kner, Peter (author), Manley, Suliana (author), Shechtman, Yoav (author), Stallinga, S. (author)
This feature issue commemorating 25 years of STED microscopy and 20 years of SIM is intended to highlight the incredible progress and growth in the field of superresolution microscopy since Stefan Hell and Jan Wichmann published the article Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion...
journal article 2020
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Cnossen, J.P. (author), Hinsdale, T.A. (author), Thorsen, R.Ø. (author), Siemons, Marijn (author), Schueder, Florian (author), Jungmann, Ralf (author), Smith, C.S. (author), Rieger, B. (author), Stallinga, S. (author)
MINFLUX offers a breakthrough in single molecule localization precision, but is limited in field of view. Here we combine centroid estimation and illumination pattern induced photon count variations in a conventional widefield imaging setup to extract position information over a typical micrometer-sized field of view. We show a near two-fold...
journal article 2020
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van der Graaff, L. (author), Van Leenders, Geert J.L.H. (author), Boyaval, Fanny (author), Stallinga, S. (author)
Whole-slide imaging systems can generate full-color image data of tissue slides efficiently, which are needed for digital pathology applications. This paper focuses on a scanner architecture that is based on a multi-line image sensor that is tilted with respect to the optical axis, such that every line of the sensor scans the tissue slide at...
journal article 2020
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Janssen, G.C.A.M. (author), van der Pers, N.M. (author), Hendrikx, R.W.A. (author), Bottger, A.J. (author), Kwakernaak, C. (author), Rieger, B. (author), Sluiter, M.H.F. (author)
Single-crystal copper films on sapphire have recently been reported upon in relation to graphene growth on these films. In the present paper the kinetics of the formation of single crystal copper films is investigated. We demonstrate the importance of heating the sapphire substrate in 1000 hPa oxygen, followed by a fast cooling prior to...
journal article 2020
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Berlich, R. (author), Stallinga, S. (author)
A practical method for determining wavefront aberrations in optical systems based on the acquisition of an extended, unknown object is presented. The approach utilizes a conventional phase diversity approach in combination with a pupil-engineered, helical point spread function (PSF) to discriminate the aberrated PSF from the object features....
journal article 2020
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Man, Z. (author), Dou, X. (author), Fu, Shenggui (author)
We show that elongating a tightly focused field in the direction perpendicular to the optical axis is possible. We demonstrate our approach by specially shaping the Pancharatnam–Berry (PB) phase. Moreover, the analytical formulae required to calculate the strength vectors and energy flux of the three-dimensional electromagnetic fields near...
journal article 2019
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Zonneveld, Hazel I. (author), Pruim, R.H.R. (author), Bos, Daniel (author), Vrooman, Henri A. (author), Muetzel, Ryan L. (author), Hofman, Albert (author), Rombouts, Serge ARB (author), van der Lugt, A.C. (author), Niessen, W.J. (author)
Structural brain markers are studied extensively in the field of neurodegeneration, but are thought to occur rather late in the process. Functional measures such as functional connectivity are gaining interest as potentially more subtle markers of neurodegeneration. However, brain structure and function are also affected by ‘normal’ brain...
journal article 2019
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Wei, P. (author), Mudde, R.F. (author), Uijttewaal, W.S.J. (author), Spanjers, H. (author), van Lier, J.B. (author), de Kreuk, M.K. (author)
This study aimed to characterise the gas-liquid flow and mixing behaviour in a gas-mixed anaerobic digester by improving phase interaction modelling using Computational Fluid Dynamics (CFD). A 2D axisymmetric model validated with experimental data was set up using an Eulerian-Eulerian method. Uncertainty factors, including bubble size, phase...
journal article 2019
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Ahmadpanahi, S.H. (author), el Gawhary, O. (author), Vismara, R. (author), Isabella, O. (author), Zeman, M. (author)
Periodic texturing is one of the main techniques to enhance light absorption in thin-film solar cells. The presence of periodicity, such as grating, allows the excitation of guided modes in the structure, thus enhancing absorption. However, grating efficiency in exciting guided modes is highly dependent on the wavelength and incident angle of...
journal article 2019
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van Rooij, J. (author), Kalkman, J. (author)
In this work we demonstrate large-scale high-sensitivity optical diffraction tomography (ODT) of zebrafish. We make this possible by three improvements. First, we obtain a large field of view while still maintaining a high resolution by using a high magnification over numerical aperture ratio digital holography set-up. With the inclusion of...
journal article 2019
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Kragt, Augustinus J.J. (author), Hoekstra, Davey C. (author), Stallinga, S. (author), Broer, Dirk J. (author), Schenning, Albertus P.H.J. (author)
Engineering the helical structure of chiral photonic materials in three dimensions remains a challenge. 3D helix engineered photonic materials are fabricated by local stratification in a photopolymerizable chiral nematic liquid crystal. The obtained chiral photonic materials reflect both handedness of circular polarized light and show super...
journal article 2019
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Hesam Mahmoudi Nezhad, N. (author), Ghaffarian Niasar, M. (author), Mohammadi Gheidari, A. (author), Hagen, C.W. (author), Kruit, P. (author)
In electrostatic charged particle lens design, optimization of a multi-electrode lens with many free optimization parameters is still quite a challenge. A fully automated optimization routine is not yet available, mainly because the lens potential calculations are often done with very time-consuming methods that require meshing of the lens...
journal article 2019
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van der Graaff, L. (author), van Leenders, Geert J. L. H. (author), Boyaval, Fanny (author), Stallinga, S. (author)
Confocal scanning microscopy is the de facto standard modality for fluorescence imaging. Point scanning, however, leads to a limited throughput and makes the technique unsuitable for fast multi-focal scanning over large areas. We propose an architecture for multi-focal fluorescence imaging that is scalable to large area imaging. The design is...
journal article 2019
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Dwivedi, P. (author), Konijnenberg, A.P. (author), Pereira, S.F. (author), Meisner, J.A. (author), Urbach, Paul (author)
Ptychography is a form of coherent diffractive imaging; it employs far-field intensity patterns of the object to reconstruct the object. In ptychography, an important limiting factor for the reconstructed image quality is the uncertainty in the probe positions. Here, we propose a new approach which uses the hybrid input-output algorithm and...
journal article 2019
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Weppelman, I.G.C. (author), Moerland, R.J. (author), Zhang, L (author), Kieft, E. (author), Kruit, P. (author), Hoogenboom, J.P. (author)
Crucial for the field of ultrafast electron microscopy is the creation of sub-picosecond, high brightness electron pulses. The use of a blanker to chop the beam that originates from a high brightness Schottky source may provide an attractive alternative to direct pulsed laser illumination of the source. We have recently presented the concept...
journal article 2019
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van der Graaff, L. (author), Stallinga, S. (author)
Confocal fluorescent imaging is the de facto standard modality for fluorescence imaging. However, the point-to-point scanning technique leads to a very limited throughput and makes the technique unsuitable for large area and fast multi-focal scanning. We propose an architecture for highly efficient 3D line confocal fluorescence imaging. Our...
conference paper 2019
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Ma, Jiliang (author), van Ommen, J.R. (author), Liu, Daoyin (author), Mudde, R.F. (author), Chen, Xiaoping (author), Wagner, E.C. (author), Liang, Cai (author)
Due to the presence of inter-particle cohesive force, cohesive particles reveal totally different fluidization behaviors as compared to the non-cohesive system. This paper studies the fluidization dynamics of Geldart B particles with varying thermal-induced cohesive forces. Multi-source X-ray tomography was applied to reconstruct 3D temporal...
journal article 2019
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Jahangir, S. (author), Wagner, E.C. (author), Mudde, R.F. (author), Poelma, C. (author)
Cavitation is a complicated multiphase phenomenon, where the production of vapor cavities leads to an opaque flow. Exploring the internal structures of the cavitating flows is one of the most significant challenges in this field of study. While it is not possible to visualize the interior of the cavity with visible light, we use X-ray...
journal article 2019
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Mandalahalli, M.M. (author), Wagner, E.C. (author), Portela, L. (author), Mudde, R.F. (author)
In this work, the effect of an electrolyte (up to 2 M of NaCl dissolved in water) on a homogeneous dense bubbly flow, in an airlift bubble column, is studied using nonintrusive techniques. X-ray and high-speed imaging are used to investigate the bubble size distribution, the local and the global gas-fraction profiles. The major effect of the...
journal article 2019
Searched for: department:"ImPhys%5C%7Eslsh%7EImaging%5C+Physics"
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