document

Automated entire thrombus density measurements for robust and comprehensive thrombus characterization in patients with acute ischemic stroke

Santos, E.M.M. (author), Niessen, W.J. (author), Yoo, A.J. (author), Berkhemer, O.A. (author), Beenen, L.F. (author), Majoie, C.B. (author), Marquering, H.A. (author)

journal article 2016

document

The Rotterdam Scan Study: Design update 2016 and main findings

Ikram, M.A. (author), Van der Lugt, A. (author), Niessen, W.J. (author), Koudstaal, P.J. (author), Krestin, G.P. (author), Hofman, A. (author), Bos, D. (author), Vernooij, M.W. (author)

Imaging plays an essential role in research on neurological diseases in the elderly. The Rotterdam Scan Study was initiated as part of the ongoing Rotterdam Study with the aim to elucidate the causes of neurological disease by performing imaging of the brain in a prospective population-based setting. Initially, in 1995 and 1999, random...

journal article 2015

document

Integrated Analysis and Visualization of Group Differences in Structural and Functional Brain Connectivity: Applications in Typical Ageing and Schizophrenia

Langen, C.D. (author), White, T. (author), Ikram, M.A. (author), Vernooij, M.W. (author), Niessen, W.J. (author)

Structural and functional brain connectivity are increasingly used to identify and analyze group differences in studies of brain disease. This study presents methods to analyze uni- and bi-modal brain connectivity and evaluate their ability to identify differences. Novel visualizations of significantly different connections comparing multiple...

journal article 2015

document

Risk Factors and Consequences of Cortical Thickness in an Asian Population

Hilal, S. (author), Xin, X. (author), Ang, S.L. (author), Tan, C.S. (author), Venketasubramanian, N. (author), Niessen, W.J. (author), Vrooman, H. (author), Wong, T.Y. (author), Chen, C. (author), Ikram, M.K. (author)

Cortical thickness has been suggested to be one of the most important markers of cortical atrophy. In this study, we examined potential risk factors of cortical thickness and its association with cognition in an elderly Asian population from Singapore. This is a cross-sectional study among 572 Chinese and Malay patients from the ongoing...

journal article 2015

document

XNAT imaging platform for BioMedBridges and CTMM TraIT (meeting abstract)

Klein, S. (author), Vast, E. (author), Van Soest, J. (author), Dekker, A. (author), Koek, M. (author), Niessen, W.J. (author)

1st Clinical Research Informatics (CRI) Solutions Day Duesseldorf, Germany, 26-27 May 2014

journal article 2015

document

Quantification of heterogeneity as a biomarker in tumor imaging: A systematic review

Alic, L. (author), Niessen, W.J. (author), Veenland, J.F. (author)

BACKGROUND: Many techniques are proposed for the quantification of tumor heterogeneity as an imaging biomarker for differentiation between tumor types, tumor grading, response monitoring and outcome prediction. However, in clinical practice these methods are barely used. This study evaluates the reported performance of the described methods and...

journal article 2014

document

Interactive local super-resolution reconstruction of whole-body MRI mouse data: A pilot study with applications to bone and kidney metastases

Dzyubachyk, O. (author), Khmelinskii, A. (author), Plenge, E. (author), Kok, P. (author), Snoeks, T.J. (author), Poot, D.H. (author), Löwik, C.W. (author), Botha, C.P. (author), Niessen, W.J. (author), Van der Weerd, L. (author), Meijering, E. (author), Lelieveldt, B.P.F. (author)

In small animal imaging studies, when the locations of the micro-structures of interest are unknown a priori, there is a simultaneous need for full-body coverage and high resolution. In MRI, additional requirements to image contrast and acquisition time will often make it impossible to acquire such images directly. Recently, a resolution...

journal article 2014

document

Older age relates to worsening of fine motor skills: A population-based study of middle-aged and elderly persons

Hoogendam, Y.Y. (author), Van der Lijn, F. (author), Vernooij, M.W. (author), Hofman, A. (author), Niessen, W.J. (author), Van der Lugt, A. (author), Arfan Ikram, M. (author), Van der Geest, J.N. (author)

Introduction: In a population-based study of 1,912 community-dwelling persons of 45 years and older, we investigated the relation between age and fine motor skills using the Archimedes spiral-drawing test. Also, we studied the effect of brain volume on fine motor skills. Methods: Participants were required to trace a template of a spiral on an...

journal article 2014

document

Development and Validation of Intracranial Thrombus Segmentation on CT Angiography in Patients with Acute Ischemic Stroke

Santos, E.M.M. (author), Marquering, H.A. (author), Berkhemer, O.A. (author), Van Zwam, W.H. (author), Van der Lugt, A. (author), Majoie, C.B. (author), Niessen, W.J. (author)

Background and Purpose: Thrombus characterization is increasingly considered important in predicting treatment success for patients with acute ischemic stroke. The lack of intensity contrast between thrombus and surrounding tissue in CT images makes manual delineation a difficult and time consuming task. Our aim was to develop an automated...

journal article 2014

document

Atherosclerotic Plaque Component Segmentation in Combined Carotid MRI and CTA Data Incorporating Class Label Uncertainty

Van Engelen, A. (author), Niessen, W.J. (author), Klein, S. (author), Groen, H.C. (author), Verhagen, H.J.M. (author), Wentzel, J.J. (author), Van der Lugt, A. (author), De Bruijne, M. (author)

Atherosclerotic plaque composition can indicate plaque vulnerability. We segment atherosclerotic plaque components from the carotid artery on a combination of in vivo MRI and CT-angiography (CTA) data using supervised voxelwise classification. In contrast to previous studies the ground truth for training is directly obtained from 3D registration...

journal article 2014

document

Can DCE-MRI explain the heterogeneity in radiopeptide uptake imaged by SPECT in a pancreatic neuroendocrine tumor model?

Bol, K. (author), Haeck, J.C. (author), Groen, H.C. (author), Niessen, W.J. (author), Bernsen, M.R. (author), De Jong, M. (author), Veenland, J.F. (author)

Although efficient delivery and distribution of treatment agents over the whole tumor is essential for successful tumor treatment, the distribution of most of these agents cannot be visualized. However, with single-photon emission computed tomography (SPECT), both delivery and uptake of radiolabeled peptides can be visualized in a neuroendocrine...

journal article 2013

document

Improving alignment in Tract-based spatial statistics: Evaluation and optimization of image registration

De Groot, M. (author), Vernooij, M.W. (author), Klein, S. (author), Arfan Ikram, M. (author), Vos, F.M. (author), Smith, S.M. (author), Niessen, W.J. (author), Andersson, J.L.R. (author)

Anatomical alignment in neuroimaging studies is of such importance that considerable effort is put into improving the registration used to establish spatial correspondence. Tract-based spatial statistics (TBSS) is a popular method for comparing diffusion characteristics across subjects. TBSS establishes spatial correspondence using a combination...

journal article 2013

document

The Thyroid Hormone Receptor Alpha Locus and White Matter Lesions: A Role for the Clock Gene REV-ERB?

Medici, M. (author), Arfan Ikram, M. (author), Van der Lijn, F. (author), Den Heijer, T. (author), Vernooij, M.W. (author), Hofman, A. (author), Niessen, W.J. (author), Visser, T.J. (author), Breteler, M.M.B. (author), Peeters, R.P. (author)

Background: Thyroid disorders are associated with an increased risk of cognitive impairment and Alzheimer's disease. Both small vessel disease and neurodegeneration have a role in the pathogenesis of cognitive impairment and Alzheimer's disease. Thyroid hormone receptor alpha (TR?) is the predominant TR in brain. The circadian clock gene REV-ERB...

journal article 2012

document

Global and focal brain volume in long-term breast cancer survivors exposed to adjuvant chemotherapy

Koppelmans, V. (author), De Ruijter, M.B. (author), Van der Lijn, F. (author), Boogerd, W. (author), Seynaeve, C. (author), Van der Lugt, A. (author), Vrooman, H. (author), Niessen, W.J. (author), Breteler, M.M.B. (author), Schagen, S.B. (author)

A limited number of studies have associated adjuvant chemotherapy with structural brain changes. These studies had small sample sizes and were conducted shortly after cessation of chemotherapy. Results of these studies indicate local gray matter volume decrease and an increase in white matter lesions. Up till now, it is unclear if non-CNS...

journal article 2011

document

The Rotterdam Scan Study: Design and update up to 2012

Ikram, M.A. (author), Van der Lugt, A. (author), Niessen, W.J. (author), Krestin, G.P. (author), Koudstaal, P.J. (author), Hofman, A. (author), Breteler, M.M.B. (author), Vernooij, M.W. (author)

Neuroimaging plays an important role in etiologic research on neurological diseases in the elderly. The Rotterdam Scan Study was initiated as part of the ongoing Rotterdam Study with the aim to unravel causes of neurological disease by performing neuroimaging in a population-based longitudinal setting. In 1995 and 1999 random subsets of the...

journal article 2011

document

Facilitating tumor functional assessment by spatially relating 3D tumor histology and in vivo MRI: Image registration approach

Alic, L. (author), Haeck, J.C. (author), Bol, K. (author), Klein, S. (author), Van Tiel, S.T. (author), Wielepolski, P.A. (author), De Jong, M. (author), Niessen, W.J. (author), Bernsen, M. (author), Veenland, J.F. (author)

Background Magnetic resonance imaging (MRI), together with histology, is widely used to diagnose and to monitor treatment in oncology. Spatial correspondence between these modalities provides information about the ability of MRI to characterize cancerous tissue. However, registration is complicated by deformations during pathological processing,...

journal article 2011

document

Estimating 3D lumen centerlines of carotid arteries in free-hand acquisition ultrasound

Carvalho, D.D.B. (author), Klein, S. (author), Akkus, Z. (author), Ten Kate, G.L. (author), Schinkel, A.F.L. (author), Bosch, J.G. (author), Van der Lugt, A. (author), Niessen, W.J. (author)

Purpose The purpose of this paper is to present a methodology to estimate the carotid artery lumen centerlines in ultrasound (US) images obtained in a free-hand examination. Challenging aspects here are speckle noise in US images, artifacts, and the lack of contrast in the direction orthogonal to the US beam direction. Method An algorithm based...

journal article 2011

document

Incidence, treatment, and case-fatality of non-traumatic subarachnoid haemorrhage in the Netherlands

Risselada, R. (author), De Vries, L.M. (author), Dippel, D.W.J. (author), Van Kooten, F. (author), Van der Lugt, A. (author), Niessen, W.J. (author), Firouzian, A. (author), Stricker, B.H.C. (author), Sturkenboom, M.C.J.M. (author)

Background Non-traumatic subarachnoid haemorrhage (SAH) is a devastating disorder and in the majority of cases it is caused by rupture of an intracranial aneurysm. No actual data are available on the incidence of non-traumatic SAH and aneursymal SAH (aSAH) in the Netherlands and little is known about treatment patterns of aSAH. Our purpose was...

journal article 2011

document

Region based level set segmentation of the outer wall of the carotid bifurcation in CTA

Vukadinovic, D. (author), Van Walsum, T. (author), Manniesing, R. (author), Rozie, S. (author), Van der Lugt, A. (author), Niessen, W.J. (author)

This paper presents a level set based method for segmenting the outer vessel wall and plaque components of the carotid artery in CTA. The method employs a GentleBoost classification framework that classifies pixels as calcified region or not, and inside or outside the vessel wall. The combined result of both classifications is used to construct...

conference paper 2011

document

Developing a tool for the validation of quantitative DCE-MRI

Bol, K. (author), Haeck, J.C. (author), Alic, L. (author), Bernsen, M. (author), De Jong, M. (author), Niessen, W.J. (author), Veenland, J.F. (author)

Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is becoming an indispensable tool to noninvasively study tumor characteristics. However, many different DCE-analysis methods are currently being used. To compare and validate different methods, histology is the gold standard. For this purpose, exact co-localization between histology...

conference paper 2011