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Clinical application of a statistical shape model for unilateral condylar hyperplasia

Klinkenberg, Edwin (author)

Unilateral Condylar Hyperplasia (UCH) is a rare and complex asymmetric growth disorder affecting the mandible. The disease is characterized by growth resembling hyperactivity in one of the condyles. Treatment of UCH requires a personalised approach that aims to stop the progression and/or correct the deformity caused by the disease. The choice...

master thesis 2023

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Depth based registration of 3D preoperative models to intraoperative patient anatomy using the HoloLens 2

Kerkhof, Enzo (author)

Purpose: Image-guided surgery can decrease perioperative complication incidences. Augmented Reality (AR) with head-mounted displays (HMDs) provides an accessible method of visualizing 3D preoperative models intraoperatively. This could provide the surgeon with an easy to use intraoperative image-guided surgery system. Image-to-patient...

master thesis 2023

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Segmentation of Deep Inferior Epigastric Artery Perforators for Breast Reconstruction using Deep Learning in Computed Tomography Angiography: A Quantitative and Qualitative Evaluation

Moes, Iris (author)

<b>Introduction: </b>Breast reconstruction after a mastectomy is crucial to improve a patient’s quality of life. The Deep Inferior Epigastric artery Perforator (DIEP) flap procedure is considered the golden standard for breast reconstruction. Three-dimensional (3D) visualization methods have shown promise in providing a better understanding of...

master thesis 2023

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Reducing Occupational Radiation Exposure in Cardiac Catheterisation Laboratories: Dose Rate Predictions and Feedback Strategies

van Deudekom, Thijs (author)

Summary<br/>Introduction<br/>The increasing use of cardiac catheterisation procedures has raised concerns about occupational radiation exposure and its associated health risks for clinicians. Radiation exposure can lead to deterministic and stochastic effects, including cataract and various cancers. To minimise these risks, the ALARA (As Low As...

master thesis 2023

document

Semi-automated Alpha Angle Computation Based on ZTE MRI to Quantitatively Evaluate CAM Morphology

Ederveen, Vera (author)

Introduction: This study developed an open access workflow for semi-automated three dimensional (3D) alpha angle measurement to allow researchers and clinicians to evaluate the 3D degree of cam morphology in a fast and objective manner, regardless of their financial resources.<br/><br/>Method: In the semi-automated workflow geometrical...

master thesis 2023

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Multimodality imaging-based response prediction and monitoring to improve clinical management of gastrointestinal stromal tumours

Weeda, Ylva (author)

Gastrointestinal stromal tumours (GISTs) are rare mesenchymal neoplasms with a worldwide incidence of one or two per 100,000. The tumours affect the entire gastrointestinal tract, but most commonly the stomach and small intestine. Neoadjuvant tyrosine kinase inhibitors (TKI) are administered in a selection of GIST patients to attain size...

master thesis 2023

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Detection of metastatic lymph nodes with multiparametric PET/MR in head and neck imaging

Kemper, Erik (author)

Detection of lymph node involvement has a significant negative impact on the treatment outcome for patients with head and neck squamous-cell carcinomas (SCC). Metastatic lymph nodes can be detected with high sensitivity by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET). However, 18F-FDG uptake is not only increased in...

master thesis 2023

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Robustness of proton treatment plans in patients with left-sided breast cancer treated in dep inspiration breath hold

Huele, Iris (author)

Purpose Deep inspiration breath hold (DIBH) in photon therapy as well as proton therapy (in free breathing) has been suggested to reduce cardiopulmonary and integral dose without compromising target coverage. The goal is to investigate the dosimetric impact on proton treatment plans of set-up variation and daily anatomy visualized on CBCT prior...

master thesis 2023

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Level localisation for lumbar surgery using ultrasound

Sluijter, Judith (author)

Wrong-level spine surgery (WLS) is a medical error with severe consequences for the patient and medical staff. The current golden standard to prevent WLS during spinal surgery is fluoroscopy images acquired by a C-arm. However, this approach uses ionising radiation and interrupts the standard surgical workflow. To overcome these disadvantages,...

master thesis 2022

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Thermal ablation of primary liver tumors: Correspondence of the predicted ablation zone with the clinically obtained ablation zone

van Erp, Gonnie (author)

<b>Purpose</b> Manufacturer’s predictions of ablation zone dimensions are the current directives for treatment planning in thermal ablation, while they are mostly based on ex vivo experiments making its reliability questionable. The aim of this study is to determine the correspondence in dimensions, volume, shape and overlap of the manufactures’...

master thesis 2022

document

The Surgeon's Experience with Head-Mounted Augmented Reality in Orthopedic Trauma Surgery

Knöps, Lucy (author)

Background<br/>Head-mounted augmented reality (AR) can be beneficial in orthopedic trauma surgery by projecting 3-dimensional (3D) holograms of preoperative imaging data, drilling or cutting planes, and osteosynthesis material, directly onto the surgeon’s field of view (FOV). For successful implementation of head-mounted AR in orthopedic trauma...

master thesis 2022

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Motion and uncertainties management in intensity-modulated proton therapy for cervical cancer

Negenman, Eva (author)

Purpose: Proton therapy has been proposed as an alternative to conventional photon therapy for the treatment of locally advanced cervical cancer (LACC) since these patients experience toxicities. Proton therapy may allow for significant sparing of the organs at risk, reducing the incidence of treatment-related morbidities. The aim of this study...

master thesis 2022

document

Automatic dental occlusion planning for orthognathic surgery: Optimization of the occlusal relation based on clinical measurements

van der Eijk, Jari (author)

<b>Introduction:</b> To correct malocclusion and enhance function and dental and facial aesthetics, orthodontic and orthognathic treatment can be considered. In the workflow of virtual surgical planning for orthognathic surgery, virtual occlusion planning is embedded as replacement for manual planning with dental cast models. An automatic...

master thesis 2022

document

Impact of Variations in Patient and Beam Parameters on Proton Therapy using Pencil Beam Scanning technique

Paramasamy, Jasika (author)

Pencil beam scanning is a technique used in the proton therapy. This technique makes use of a thin beam which can irradiate each spot at millimetre precision. It is a very promising technique, especially for more radiation sensitive areas, e.g. lung carcinogenesis, as it can spare more healthy surrounding tissue compared to conventional...

master thesis 2022

document

Radiostereometric Analysis in Unicompartmental Knee Arthroplasty; An Analysis of Marker Placement

Gevers, Imke (author)

Background: Radiostereometric analysis (RSA) is a technique to assess early migration, which has a predictive value for early failure of unicompartmental knee arthroplasty (UKA). To successfully analyze the RSA images it is important to have a sufficient amount of visiblemarkers with an acceptable three-dimensional distribution.<br/>Objective:...

master thesis 2022

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Development of a novel method to perform morphological measurements on 3D models of the calcaneus

Wakker, Alexander (author)

Currently, morphological measurements on conventional radiographs are used to assess calcaneal fractures. The two most commonly used angles for determining the degree of depression and displacement of such a fracture are Böhler’s angle (BA) and the Critical angle of Gissane (CAG). However, conventional radiographs only provide limited amount of...

master thesis 2022

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Three-Dimensional Visualization for Double Outlet Right Ventricle Surgical Planning: 3D Printed Models vs. 3D Virtual Reality Reconstruction: Double outlet right ventricle: A complex three-dimensional problem

Peek, Jet (author)

Objectives: In double outlet right ventricle (DORV) both the pulmonary artery and the aorta originate predominantly from the right ventricle (RV) and a ventricular septum defect (VSD) is present. Each DORV patient requires an individual surgical approach. In complex cases the optimal surgical approach may be difficult to assess based on...

master thesis 2021

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Predictive modelling of facial features from DNA

Jans, Guusje (author)

Background: In recent years, attention to the genetic architecture of normal-range variation in facial morphology has risen and through GWAS genetic loci associated with facial morphology have been identified. However these give no insight in how the face is shaped by genetics. To investigate the relationship between the genotype and the...

master thesis 2021

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AI & MRI: improved mapping of oxygenation in brain tumours

Rosbergen, Mathijs (author)

Introduction: Gliomas are the most common primary malignant brain tumours with a very poor survival. Resistance to chemotherapy and radiotherapy often occurs in these tumours due to hypoxia, which can be caused by different oxygenation parameters. Multiple magnetic resonance imaging (MRI) techniques are able to assess these oxygenation...

master thesis 2021

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Evaluation of the positioning of virtually planned polyetheretherketone patient-specific implants and surgical guides in craniofacial surgery

Nagtegaal, Larissa (author)

Purpose: Patient-specific implants (PSIs) and surgical guides are widely used nowadays for the reconstruction of craniofacial defects. In this research, we quantitatively compared the realised position of craniofacial PSIs with the planned position and we calculated the difference between the realised osteotomy and the planned osteotomy if a...

master thesis 2021