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Weeda, Ylva (author)
Gastrointestinal stromal tumours (GISTs) are rare mesenchymal neoplasms with a worldwide incidence of one or two per 100,000. The tumours affect the entire gastrointestinal tract, but most commonly the stomach and small intestine. Neoadjuvant tyrosine kinase inhibitors (TKI) are administered in a selection of GIST patients to attain size...
master thesis 2023
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Kemper, Erik (author)
Detection of lymph node involvement has a significant negative impact on the treatment outcome for patients with head and neck squamous-cell carcinomas (SCC). Metastatic lymph nodes can be detected with high sensitivity by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET). However, 18F-FDG uptake is not only increased in...
master thesis 2023
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Huele, Iris (author)
Purpose Deep inspiration breath hold (DIBH) in photon therapy as well as proton therapy (in free breathing) has been suggested to reduce cardiopulmonary and integral dose without compromising target coverage. The goal is to investigate the dosimetric impact on proton treatment plans of set-up variation and daily anatomy visualized on CBCT prior...
master thesis 2023
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Sluijter, Judith (author)
Wrong-level spine surgery (WLS) is a medical error with severe consequences for the patient and medical staff. The current golden standard to prevent WLS during spinal surgery is fluoroscopy images acquired by a C-arm. However, this approach uses ionising radiation and interrupts the standard surgical workflow. To overcome these disadvantages,...
master thesis 2022
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van Erp, Gonnie (author)
<b>Purpose</b> Manufacturer’s predictions of ablation zone dimensions are the current directives for treatment planning in thermal ablation, while they are mostly based on ex vivo experiments making its reliability questionable. The aim of this study is to determine the correspondence in dimensions, volume, shape and overlap of the manufactures’...
master thesis 2022
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Knöps, Lucy (author)
Background<br/>Head-mounted augmented reality (AR) can be beneficial in orthopedic trauma surgery by projecting 3-dimensional (3D) holograms of preoperative imaging data, drilling or cutting planes, and osteosynthesis material, directly onto the surgeon’s field of view (FOV). For successful implementation of head-mounted AR in orthopedic trauma...
master thesis 2022
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Negenman, Eva (author)
Purpose: Proton therapy has been proposed as an alternative to conventional photon therapy for the treatment of locally advanced cervical cancer (LACC) since these patients experience toxicities. Proton therapy may allow for significant sparing of the organs at risk, reducing the incidence of treatment-related morbidities. The aim of this study...
master thesis 2022
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van der Eijk, Jari (author)
<b>Introduction:</b> To correct malocclusion and enhance function and dental and facial aesthetics, orthodontic and orthognathic treatment can be considered. In the workflow of virtual surgical planning for orthognathic surgery, virtual occlusion planning is embedded as replacement for manual planning with dental cast models. An automatic...
master thesis 2022
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Paramasamy, Jasika (author)
Pencil beam scanning is a technique used in the proton therapy. This technique makes use of a thin beam which can irradiate each spot at millimetre precision. It is a very promising technique, especially for more radiation sensitive areas, e.g. lung carcinogenesis, as it can spare more healthy surrounding tissue compared to conventional...
master thesis 2022
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Gevers, Imke (author)
Background: Radiostereometric analysis (RSA) is a technique to assess early migration, which has a predictive value for early failure of unicompartmental knee arthroplasty (UKA). To successfully analyze the RSA images it is important to have a sufficient amount of visiblemarkers with an acceptable three-dimensional distribution.<br/>Objective:...
master thesis 2022
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Wakker, Alexander (author)
Currently, morphological measurements on conventional radiographs are used to assess calcaneal fractures. The two most commonly used angles for determining the degree of depression and displacement of such a fracture are Böhler’s angle (BA) and the Critical angle of Gissane (CAG). However, conventional radiographs only provide limited amount of...
master thesis 2022
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Peek, Jet (author)
Objectives: In double outlet right ventricle (DORV) both the pulmonary artery and the aorta originate predominantly from the right ventricle (RV) and a ventricular septum defect (VSD) is present. Each DORV patient requires an individual surgical approach. In complex cases the optimal surgical approach may be difficult to assess based on...
master thesis 2021
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Jans, Guusje (author)
Background: In recent years, attention to the genetic architecture of normal-range variation in facial morphology has risen and through GWAS genetic loci associated with facial morphology have been identified. However these give no insight in how the face is shaped by genetics. To investigate the relationship between the genotype and the...
master thesis 2021
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Rosbergen, Mathijs (author)
Introduction: Gliomas are the most common primary malignant brain tumours with a very poor survival. Resistance to chemotherapy and radiotherapy often occurs in these tumours due to hypoxia, which can be caused by different oxygenation parameters. Multiple magnetic resonance imaging (MRI) techniques are able to assess these oxygenation...
master thesis 2021
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Nagtegaal, Larissa (author)
Purpose: Patient-specific implants (PSIs) and surgical guides are widely used nowadays for the reconstruction of craniofacial defects. In this research, we quantitatively compared the realised position of craniofacial PSIs with the planned position and we calculated the difference between the realised osteotomy and the planned osteotomy if a...
master thesis 2021
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Mostert, Marijn (author)
Vertebral fractures are the most common osteoporotic fractures, with a prevalence of 12-20% in Europe, making them a major health problem because of the associated morbidity, mortality and costs. Without adequate treatment, vertebral fractures are often followed by subsequent fractures, leading to further invalidation and deterioration of health...
master thesis 2021
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van der Loo, Wouter (author)
Coronary artery disease (CAD) is one of the leading causes of death and disability worldwide. In CAD, the coronary arteries, that supply the myocardium with oxygen, are narrowed or even blocked by a process called atherosclerosis. Invasive coronary angiography (ICA) is the gold standard for the diagnosis of CAD, as well as for intraprocedural...
master thesis 2021
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Corbeau, Anouk (author)
Each year, more than 800 women in the Netherlands are diagnosed with cervical cancer, of which approximately half have locally advanced disease. The standard treatment for locally advanced cervical cancer (LACC) is external beam radiotherapy (EBRT) with concurrent chemotherapy followed by brachytherapy. Many patients experience some degree of...
master thesis 2021
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Mooij, Charlotte (author)
INTRODUCTIOND istal radius fractures are traditionally treated with plaster casts. Although this has been the gold standard for treatment for years, it also comes with disadvantages. These are the weight, not being water-resistant and a lack of ventilation, leading to skin problems, itching and compromised hygiene. Furthermore, plaster has no...
master thesis 2021
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van der Bie, Judith (author)
According to the World Health Organization 40 million amputees are living in developing countries1. An amputation has a great impact on the quality of life of a patient. In general, patients have limited mobility, often lack of confidence and consequently are at times excluded from participating in society2. Prosthetic rehabilitation could help...
master thesis 2021
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