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Enhanced Bone Regeneration of Cortical Segmental Bone Defects Using Porous Titanium Scaffolds Incorporated with Colloidal Gelatin Gels for Timeand Dose-Controlled Delivery of Dual Growth Factors

Van der Stok, J. (author), Wang, H. (author), Yavari, S.A. (author), Siebelt, M. (author), Sandker, M. (author), Waarsing, J.H. (author), Verhaar, J.A.N. (author), Jahr, H. (author), Zadpoor, A.A. (author), Leeuwenburgh, S.C.G. (author), Weinans, H. (author)

Porous titanium scaffolds are a promising class of biomaterials for grafting large bone defects, because titanium provides sufficient mechanical support, whereas its porous structure allows bone ingrowth resulting in good osseointegration. To reinforce porous titanium scaffolds with biological cues that enhance and continue bone regeneration,...

journal article 2013

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The Thyroid Hormone Receptor Alpha Locus and White Matter Lesions: A Role for the Clock Gene REV-ERB?

Medici, M. (author), Arfan Ikram, M. (author), Van der Lijn, F. (author), Den Heijer, T. (author), Vernooij, M.W. (author), Hofman, A. (author), Niessen, W.J. (author), Visser, T.J. (author), Breteler, M.M.B. (author), Peeters, R.P. (author)

Background: Thyroid disorders are associated with an increased risk of cognitive impairment and Alzheimer's disease. Both small vessel disease and neurodegeneration have a role in the pathogenesis of cognitive impairment and Alzheimer's disease. Thyroid hormone receptor alpha (TR?) is the predominant TR in brain. The circadian clock gene REV-ERB...

journal article 2012

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Face and Construct Validity of the SimSurgery SEP VR Simulator for Salpingectomy in Case of Ectopic Pregnancy

Hessel, M. (author), Buzink, S.N. (author), Schoot, B.C. (author), Jakimowicz, J.J. (author)

Objective: To secure patient safety, skills needed for laparoscopy are preferably obtained in a non-patient setting. Therefore, we assessed face and construct validity of performance of a salpingectomy in case of ectopic pregnancy on the SimSurgery SEP VR simulator. Materials and Methods: Fifteen experienced gynecologists (?ESGE level 2) and 17...

journal article 2012

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Electrochemically Induced Crystallization as a Sustainable Method for Product Recovery of Building Block Chemicals: Techno-Economic Evaluation of Fumaric Acid Separation

Nasrollahnejad, T. (author), Urbanus, J. (author), Ter Horst, J.H. (author), Verdoes, D. (author), Roelands, C.P.M. (author)

Carboxylic acids are key platform chemicals for use as biobased alternatives for fossil-based applications. State-of-the-art fermentations of carboxylic acids at neutral pH with downstream product recovery by pH-shift crystallization are not sustainable due to the accompanied production of waste salts. To earn the label‘‘sustainable,’’ salts...

journal article 2012

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Disruption of Functional Brain Networks in Alzheimer’s Disease: What Can We Learn from Graph Spectral Analysis of Resting-State Magnetoencephalography?

De Haan, W. (author), Van der Flier, W.M. (author), Wang, H. (author), Van Mieghem, P.F.A. (author), Scheltens, P. (author), Stam, C.J. (author)

In Alzheimer’s disease (AD), structural and functional brain network organization is disturbed. However, many of the present network analysis measures require a priori assumptions and methodological choices that influence outcomes and interpretations. Graph spectral analysis (GSA) is a more direct algebraic method that describes network...

journal article 2012

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Impact of Velvet Complex on Transcriptome and Penicillin G Production in Glucose-Limited Chemostat Cultures of a ?-Lactam High-Producing Penicillium chrysogenum Strain

Veiga, T. (author), Nijland, J.G. (author), Driessen, A.J.M. (author), Bovenberg, R.A.L. (author), Touw, H. (author), Van den Berg, M.A. (author), Pronk, J.T. (author), Daran, J.M. (author)

The multicomponent global regulator Velvet complex has been identified as a key regulator of secondary metabolite production in Aspergillus and Penicillium species. Previous work indicated a massive impact of PcvelA and PclaeA deletions on penicillin production in prolonged batch cultures of P. chrysogenum, as well as substantial changes in...

journal article 2012

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Satellite Sanitary Systems in Kampala, Uganda

Letema, S. (author), Van Vliet, B. (author), Van Lier, J.B. (author)

Satellite sewage collection and treatment systems have been independently developed and managed in East African cities outside the centrally planned and sewered areas. A satellite approach is a promising provisioning option parallel to public sewerage for middle- and high-income residential areas, endowed institutions, and government facilities....

journal article 2011

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E-health Applications and Services for Patient Empowerment: Directions for Best Practices in The Netherlands

Alpay, L.L. (author), Blanson Henkemans, O. (author), Otten, W. (author), Rövekamp, T.A.J.M. (author), Dumay, A.C.M. (author)

Objective: E-health may enable the empowerment process for patients, particularly the chronically ill. However, e-health is not always designed with the requirements of patient empowerment in mind. Drawing on evidence-based e-health studies, we propose directions for best practices to develop e-health that promotes patient empowerment. Methods:...

journal article 2010

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An Electric Scooter Simulation Program for Training the Driving Skills of Stroke Patients with Mobility Problems: A Pilot Study

Jannink, M.J.A. (author), Erren-Wolters, C.V. (author), De Kort, A.C. (author), Van der Kooij, H. (author)

This paper describes an electric scooter simulation program and a first evaluation study in which we explored if it is possible to train the driving skills of future users of electric mobility scooters by means of an electric scooter simulation program in addition to conventional electric scooter training. Within this explorative study, 10...

journal article 2008

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Biclustering Sparse Binary Genomic Data

Van Uitert, M. (author), Meuleman, W. (author), Wessels, L.F.A. (author)

Genomic datasets often consist of large, binary, sparse data matrices. In such a dataset, one is often interested in finding contiguous blocks that (mostly) contain ones. This is a biclustering problem, and while many algorithms have been proposed to deal with gene expression data, only two algorithms have been proposed that specifically deal...

journal article 2008

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Attribution of Foodborne Pathogens Using Structured Expert Elicitation

Havelaar, A.H. (author), Vargas Galindo, A. (author), Kurowicka, D. (author), Cooke, R.M. (author)

Objectives: To estimate the fraction of human cases of enterically transmitted illness by five major pathways (food, environment, direct animal contact, human–human transmission, and travel) and by 11 groups within the food pathway. Methods: Food safety experts were asked to provide their estimates of the most likely range for each of the...

journal article 2008

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Do Self-Statements Enhance the Effectiveness of Virtual Reality Exposure Therapy? A Comparative Evaluation in Acrophobia

Krijn, M. (author), Emmelkamp, P.M.G. (author), Olafsson, R.P. (author), Schuemie, M.J. (author), Van der Mast, C.A.P.G. (author)

There is a clear need for more detailed analysis of the role of cognitive self-statements in virtual reality exposure therapy (VRET). To date, no research on this topic has been done. The primary aim of this study was to investigate whether coping self-statements would enhance the effectiveness of VRET. In a randomized crossover design, 26...

journal article 2007

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Lanthanide-Loaded Liposomes for Multimodality Imaging and Therapy

Zielhuis, S.W. (author), Seppenwoolde, J.H. (author), Mateus, V.A.P. (author), Bakker, C.J.G. (author), Krijger, G.C. (author), Storm, G. (author), Zonnenberg, B.A. (author), Van het Schip, A.D. (author), Koning, G.A. (author), Nijsen, J.F.W. (author)

Many advanced molecular imaging agents are currently being investigated preclinically. Especially, liposomes, have proven to be very promising carrier systems for diagnostic agents for use in single-photon emission computed tomography (SPECT) or magnetic resonance imaging (MRI), as well as for therapeutic agents to treat diseases such as cancer....

journal article 2006

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Optimization, Application, and Interpretation of Lactate Dehydrogenase Measurements in Microwell Determination of Cell Number and Toxicity

Wolterbeek, H.T. (author), Van der Meer, A.J.G.M. (author)

The lactate dehydrogenase (LDH) assay was addressed for its sensitivity, disturbances by foaming, and cell number and size. Cells were from a U-251 MG grade IV human glioblastoma brain tumor cell line used in 100-µl well volumes. Cells were counted by microscopy and Coulter counting; assays were LDH or trypan blue. The results indicate increased...

journal article 2005

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The Perspective Effect of Wide-Angle Lenses in Laparoscopes

Wentink, M. (author), Fischer, H. (author), Dankelman, J. (author), Stassen, L.P.S. (author), Wieringa, P.A. (author)

Purpose: To evaluate the effect of perspective distortion of wide-angle lenses in laparoscopes on hand-eye coordination during endoscopic manipulation. Methods: Sixteen subjects repeatedly performed a standardized positioning task in a pelvi-trainer under two conditions. The subjects had no prior experience with endoscopic manipulation. In one...

journal article 2002

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Assessment of the Ergonomically Optimal Operating Surface Height for Laparoscopic Surgery

Van Veelen, M.A. (author), Kazemier, G. (author), Koopman, J. (author), Goossens, R.H.M. (author), Meijer, D.W. (author)

Purpose: The aim of this study was to find the ergonomically optimal operating surface height for laparoscopic surgery in order to reduce discomfort in the upper extremities of the operators and the assistants. The operating surface height was defined as the level of the abdominal wall of a patient with pneumoperitoneum. Materials and Methods:...

journal article 2002

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Virtual Reality Treatment in Acrophobia: A Comparison with Exposure in Vivo

Emmelkamp, P.M.G. (author), Bruynzeel, M. (author), Drost, L. (author), Van der Mast, C.A.P.G. (author)

The aim of the present study was to evaluate the effectiveness of low-budget virtual reality exposure versus exposure in vivo in a within-group design in 10 individuals suffering from acrophobia. Virtual reality exposure was found to be at least as effective as exposure in vivo on anxiety and avoidance as measured with the Acrophobia...

journal article 2001

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Problems with Laparoscopic Instruments: Opinions of Experts

Den Boer, K.T. (author), De Jong, T. (author), Dankelman, J. (author), Gouma, D.J. (author)

Introduction: Laparoscopic surgery is particularly known for its complex technique, which calls for operative analysis of laparoscopic instruments. This study investigates the opinion of experts about clinical problems with instruments occurring during laparoscopic surgery. Methods: A questionnaire was used to obtain the opinions of expert...

journal article 2001

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Presence for Design: Conveying Atmosphere through Video Collages

Keller, A.I. (author), Stappers, P.J. (author)

Product designers use imagery for inspiration in their creative design process. To support creativity, designers apply many tools and techniques, which often rely on their ability to be inspired by found and previously made visual material and to experience the atmosphere of the user environment. Computer tools and developments in VR offer...

journal article 2001

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Research on Presence in Virtual Reality: A Survey

Schuemie, M.J. (author), Van der Straaten, P. (author), Krijn, M. (author), Van der Mast, C.A.P.G. (author)

Virtual Reality (VR) is starting to be used in psychological therapy around the world. However, a thorough understanding of the reason why VR is effective and what effect it has on the human psyche is still missing. Most research on this subject is related to the concept of presence. This paper gives an up-to-date overview of research in this...

journal article 2001