Searched for: mods_originInfo_publisher_s%3A%22Oxford%255C+University%255C+Press%22
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Dobbe, R.I.J. (author)
This chapter formulates seven lessons for preventing harm in artificial intelligence (AI) systems based on insights from the field of system safety for software-based automation in safety-critical domains. New applications of AI across societal domains and public organizations and infrastructures come with new hazards, which lead to new forms of...
book chapter 2022
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Wagner, Ben (author), Kuklis, Lubos (author)
This chapter provides an overview of the main problems associated with basing public regulatory decisions on unverified data, before sketching out some ideas of what a solution might look like. In order to do this, the chapter develops the concept of auditing intermediaries. After discussing which problems the concept of auditing intermediaries...
book chapter 2021
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Gan, S. (author), Wang, S. (author), Chen, Y. (author), Qu, S. (author), Zu, S. (author)
Direct imaging of simultaneous-source (or blended) data, without the need of deblending, requires a precise subsurface velocity model. In this paper, we focus on the velocity analysis of simultaneous-source data using the normal moveout-based velocity picking approach.We demonstrate that it is possible to obtain a precise velocity model directly...
journal article 2016
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Miller, S.R.M. (author)
Terrorism, the use of military force in Afghanistan, Iraq and Syria, and the fatal police shootings of unarmed persons have all contributed to renewed interest in the ethics of police and military use of lethal force and its moral justification.<br/>In this book, philosopher Seumas Miller analyzes the various moral justifications and moral...
book 2016
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Gehrmann, T. (author), Reinders, M.J.T. (author)
Background: With more and more genomes being sequenced, detecting synteny between genomes becomes more and more important. However, for microorganisms the genomic divergence quickly becomes large, resulting in different codon usage and shuffling of gene order and gene elements such as exons. Results: We present Proteny, a methodology to detect...
journal article 2015
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Allahyar, A. (author), De Ridder, J. (author)
Motivation: Breast cancer outcome prediction based on gene expression profiles is an important strategy for personalize patient care. To improve performance and consistency of discovered markers of the initial molecular classifiers, network-based outcome prediction methods (NOPs) have been proposed. In spite of the initial claims, recent studies...
journal article 2015
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Mans, R. (author), Van Rossum, H.M. (author), Wijsman, M. (author), Backx, A. (author), Kuijpers, N.G.A. (author), van den Broek, M. (author), Daran-Lapujade, P.A.S. (author), Pronk, J.T. (author), Van Maris, A.J.A. (author), Daran, J.G. (author)
A variety of techniques for strain engineering in Saccharomyces cerevisiae have recently been developed. However, especially when multiple genetic manipulations are required, strain construction is still a time-consuming process. This study describes new CRISPR/Cas9-based approaches for easy, fast strain construction in yeast and explores their...
journal article 2015
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Chintakayala, K. (author), Sellars, L.E. (author), Singh, S.S. (author), Shahapure, R. (author), Westerlaken, I. (author), Meyer, A.S. (author), Dame, R.T. (author), Grainger, D.C. (author)
Curved DNA binding protein A (CbpA) is a co-chaperone and nucleoid associated DNA binding protein conserved in most ?-proteobacteria. Best studied in Escherichia coli, CbpA accumulates to >2500 copies per cell during periods of starvation and forms aggregates with DNA. However, the molecular basis for DNA binding is unknown; CbpA lacks motifs...
journal article 2015
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Wolstencroft, M. (author), King, M.A. (author), Whitehouse, P.L. (author), Bentley, M.J. (author), Nield, G.A. (author), King, E.C. (author), McMillan, M. (author), Shepherd, A. (author), Barletta, V. (author), Bordoni, A. (author), Riva, R.E.M. (author), Didova, O. (author), Gunter, B.C. (author)
The measurement of ongoing ice-mass loss and associated melt water contribution to sea-level change from regions such as West Antarctica is dependent on a combination of remote sensing methods. A key method, the measurement of changes in Earth's gravity via the GRACE satellite mission, requires a potentially large correction to account for the...
journal article 2015
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Van der Neut, J.R. (author), Vasconcelos, I. (author), Wapenaar, C.P.A. (author)
Iterative substitution of the coupled Marchenko equations is a novel methodology to retrieve the Green's functions from a source or receiver array at an acquisition surface to an arbitrary location in an acoustic medium. The methodology requires as input the single-sided reflection response at the acquisition surface and an initial focusing...
journal article 2015
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Janissen, R. (author), Berghuis, B.A. (author), Dulin, D. (author), Wink, M. (author), Van Laar, T. (author), Dekker, N.H. (author)
Magnetic tweezers are a powerful single-molecule technique that allows real-time quantitative investigation of biomolecular processes under applied force. High pulling forces exceeding tens of picoNewtons may be required, e.g. to probe the force range of proteins that actively transcribe or package the genome. Frequently, however, the...
journal article 2014
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Hulsman, M. (author), Dimitrakopoulos, C. (author), De Ridder, J. (author)
MOTIVATION: The network architecture of physical protein interactions is an important determinant for the molecular functions that are carried out within each cell. To study this relation, the network architecture can be characterized by graph topological characteristics such as shortest paths and network hubs. These characteristics have an...
journal article 2014
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Wapenaar, C.P.A. (author), Slob, E.C. (author)
Recent work on the Marchenko equation has shown that the scalar 3-D Green’s function for a virtual source in the subsurface can be retrieved from the single-sided reflection response at the surface and an estimate of the direct arrival. Here, we discuss the first steps towards extending this result to multicomponent data. After introducing a...
journal article 2014
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Martin-Hernandez, J. (author), Li, Z. (author), Van Mieghem, P. (author)
One of the better studied topology metrics of complex networks is the second smallest eigenvalue of the Laplacian matrix of a network’s graph, referred to as the algebraic connectivity mN-1. This spectral metric plays a decisive role in synchronization of coupled oscillators, network robustness, consensus problems, belief propagation, graph...
journal article 2014
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Hashemi Farahani, H. (author), Ditmar, P.G. (author), Klees, R. (author), De Teixeira da Encarnacao, J.G. (author), Liu, X. (author), Zhao, Q. (author), Guo, J. (author)
The ability of satellite gravimetry data to validate global static models of the Earth’s gravity field is studied. Two types of data are considered: K-band ranging (KBR) data from the Gravity Recovery and Climate Experiment (GRACE) mission and Satellite Gravity Gradiometry (SGG) data from the GOCE (Gravity field and steady-state Ocean...
journal article 2013
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Hedman, L. (author), Manley, D. (author), Van Ham, M. (author), Östh, J. (author)
Marie Curie programme under the European Union's Seventh Framework Programme (FP/2007-2013) / Career Integration Grant n. PCIG10-GA-2011-303728 (CIG Grant NBHCHOICE, Neighbourhood choice, neighbourhood sorting, and neighbourhood effects). Studies of neighbourhood effects typically investigate the instantaneous effect of point-in-time measures of...
journal article 2013
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Nishitsuji, Y. (author), Mori, J. (author)
We estimated source parameters of 216 intermediate-depth (65–150 km) earthquakes (Mw 4.0–7.0) in the Pacific slab beneath Japan along using Hi-net data. We made determinations of static stress drop, radiated energy and radiation efficiency, along with estimates of the whole path attenuation, to study the source scaling as a function of...
journal article 2013
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Mulder, W.A. (author), Zhebel, E. (author), Minisini, S. (author)
We analyse the time-stepping stability for the 3-D acoustic wave equation, discretized on tetrahedral meshes. Two types of methods are considered: mass-lumped continuous finite elements and the symmetric interior-penalty discontinuous Galerkin method. Combining the spatial discretization with the leap-frog time-stepping scheme, which is second...
journal article 2013
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Van Dalen, K.N. (author), Wapenaar, C.P.A. (author), Halliday, D.F. (author)
Virtual-source surface wave responses can be retrieved using the crosscorrelation (CC) of wavefields observed at two receivers. Higher mode surface waves cannot be properly retrieved when there is a lack of subsurface sources that excite these wavefields, as is often the case. In this paper, we present a multidimensional-deconvolution (MDD)...
journal article 2013
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Straver, R. (author), Sistermans, E.A. (author), Holstege, H. (author), Visser, A. (author), Oudejans, C.B.M. (author), Reinders, M.J.T. (author)
Genetic disorders can be detected by prenatal diagnosis using Chorionic Villus Sampling, but the 1:100 chance to result in miscarriage restricts the use to fetuses that are suspected to have an aberration. Detection of trisomy 21 cases noninvasively is now possible owing to the upswing of next-generation sequencing (NGS) because a small...
journal article 2013
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