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Schrauwen, J.T.C. (author), Karanasos, A. (author), Van Ditzhuijzen, N.S. (author), Aben, J.P. (author), Van der Steen, A.F.W. (author), Wentzel, J.J. (author), Gijsen, F.J.H. (author)
Wall shear stress (WSS) plays a key role in the onset and progression of atherosclerosis in human coronary arteries. Especially sites with low and oscillating WSS near bifurcations have a higher propensity to develop atherosclerosis. WSS computations in coronary bifurcations can be performed in angiography-based 3D reconstructions. It is...
journal article 2015
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Qu, C. (author), Ling, Y. (author), Heynderickx, I. (author), Brinkman, W.P. (author)
Bystanders in a real world's social setting have the ability to influence people’s beliefs and behavior. This study examines whether this effect can be recreated in a virtual environment, by exposing people to virtual bystanders in a classroom setting. Participants (n = 26) first witnessed virtual students answering questions from an English...
journal article 2015
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Fuzita, F.J. (author), Pinkse, M.W.H. (author), Patane, J.S.L. (author), Juliano, M.A. (author), Verhaert, P.D.E.M. (author), Lopes, A.R. (author)
Scorpions are among the oldest terrestrial arthropods and they have passed through small morphological changes during their evolutionary history on land. They are efficient predators capable of capturing and consuming large preys and due to envenomation these animals can become a human health challenge. Understanding the physiology of scorpions...
journal article 2015
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Nieuwstadt, H.A. (author), Kassar, Z.A.M. (author), Van der Lugt, A. (author), Breeuwer, M. (author), Van der Steen, A.F.W. (author), Wentzel, J.J. (author), Gijsen, F.J.H. (author)
Background The benefits of a decreased slice thickness and/or in-plane voxel size in carotid MRI for atherosclerotic plaque component quantification accuracy and biomechanical peak cap stress analysis have not yet been investigated in detail because of practical limitations. Methods In order to provide a methodology that allows such an...
journal article 2015
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Van den Berg, B.A. (author), Reinders, M.J.T. (author), De Ridder, D. (author), De Beer, T.A.P. (author)
A variety of methods that predict human nonsynonymous single nucleotide polymorphisms (SNPs) to be neutral or disease-associated have been developed over the last decade. These methods are used for pinpointing disease-associated variants in the many variants obtained with next-generation sequencing technologies. The high performances of current...
journal article 2015
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Van den Brom, R. (author), Roest, H.J. (author), De Bruin, A. (author), Dercksen, D. (author), Santman-Berends, I. (author), Van der Hoek, W. (author), Dinkla, A. (author), Vellema, J. (author), Vellema, P. (author)
In 2007, Q fever started to become a major public health problem in the Netherlands, with small ruminants as most probable source. In order to reduce environmental contamination, control measures for manure were implemented because of the assumption that manure was highly contaminated with Coxiella burnetii. The aims of this study were 1) to...
journal article 2015
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Liu, M. (author), Li, D. (author), Qin, P. (author), Liu, C. (author), Wang, H. (author), Wang, F. (author)
Networks can be used to describe the interconnections among individuals, which play an important role in the spread of disease. Although the small-world effect has been found to have a significant impact on epidemics in single networks, the small-world effect on epidemics in interconnected networks has rarely been considered. Here, we study the...
journal article 2015
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Gallie, J. (author), Libby, E. (author), Bertels, F. (author), Jendresen, C.B. (author), Martinussen, J. (author), Kilstrup, M. (author), Desprat, N. (author), Buffing, M.F. (author), Sauer, U. (author), Beaumont, H.J.E. (author), Rainey, P.B. (author)
Phenotype switching is commonly observed in nature. This prevalence has allowed the elucidation of a number of underlying molecular mechanisms. However, little is known about how phenotypic switches arise and function in their early evolutionary stages. The first opportunity to provide empirical insight was delivered by an experiment in which...
journal article 2015
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Huser, C.A. (author), Gilroy, K.L. (author), De Ridder, J. (author), Kilbey, A. (author), Borland, G. (author), Mackay, N. (author), Jenkins, A. (author), Bell, M. (author), Herzyk, P. (author), Van der Weyden, L. (author)
Retroviral insertional mutagenesis (RIM) is a powerful tool for cancer genomics that was combined in this study with deep sequencing (RIM/DS) to facilitate a comprehensive analysis of lymphoma progression. Transgenic mice expressing two potent collaborating oncogenes in the germ line (CD2-MYC, -Runx2) develop rapid onset tumours that can be...
journal article 2014
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Cozzoli, F. (author), Eelkema, M. (author), Bouma, T.J. (author), Ysebaert, T. (author), Escaravage, V. (author), Herman, P.M.J. (author)
Human infrastructures can modify ecosystems, thereby affecting the occurrence and spatial distribution of organisms, as well as ecosystem functionality. Sustainable development requires the ability to predict responses of species to anthropogenic pressures. We investigated the large scale, long term effect of important human alterations of...
journal article 2014
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Vegter, R.J.K. (author), Lamoth, C.J. (author), De Groot, S. (author), Veeger, D.H.E.J. (author), Van der Woude, L.H.V. (author)
Handrim wheelchair propulsion is a cyclic skill that needs to be learned during rehabilitation. Yet it is unclear how interindividual differences in motor learning impact wheelchair propulsion practice. Therefore we studied how early-identified motor learning styles in novice able-bodied participants impact the outcome of a low-intensity...
journal article 2014
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De Ronde, J.J. (author), Bonder, M.J. (author), Lips, E.H. (author), Rodenhuis, S. (author), Wessels, L.F.A. (author)
Introduction: Despite continuous efforts, not a single predictor of breast cancer chemotherapy resistance has made it into the clinic yet. However, it has become clear in recent years that breast cancer is a collection of molecularly distinct diseases. With ever increasing amounts of breast cancer data becoming available, we set out to study if...
journal article 2014
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De Ridder, J. (author), Bromberg, Y. (author), Michaut, M. (author), Satagopam, V.P. (author), Corpas, M. (author), MacIntyre, G. (author), Alexandrov, T. (author)
journal article 2013
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Ling, Y. (author), Nefs, H.T. (author), Brinkman, W.P. (author), Qu, C. (author), Heynderickx, I. (author)
In this paper we report two experiments in which the effect of perspective projection on presence and space perception was investigated. In Experiment 1, participants were asked to score a presence questionnaire when looking at a virtual classroom. We manipulated the vantage point, the viewing mode (binocular versus monocular viewing), the...
journal article 2013
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Van Tiel, J. (author), Reijman, M. (author), Bos, P.K. (author), Hermans, J. (author), Van Buul, G.M. (author), Bron, E.E. (author), Klein, S. (author), Verhaar, J.A.N. (author), Krestin, G.P. (author), Bierma-Zeinstra, S.M.A. (author), Weinans, H. (author), Kotek, G. (author), Oei, E.H.G. (author)
journal article 2013
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Hol, F.J.H. (author), Galajda, P. (author), Nagy, K. (author), Woolthuis, R.G. (author), Dekker, C. (author), Keymer, J.E. (author)
Cooperative organisms are ubiquitous in nature, despite their vulnerability to exploitation by cheaters. Although numerous theoretical studies suggest that spatial structure is critical for cooperation to persist, the spatial ecology of microbial cooperation remains largely unexplored experimentally. By tracking the community dynamics of...
journal article 2013
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Bol, K. (author), Haeck, J.C. (author), Groen, H.C. (author), Niessen, W.J. (author), Bernsen, M.R. (author), De Jong, M. (author), Veenland, J.F. (author)
Although efficient delivery and distribution of treatment agents over the whole tumor is essential for successful tumor treatment, the distribution of most of these agents cannot be visualized. However, with single-photon emission computed tomography (SPECT), both delivery and uptake of radiolabeled peptides can be visualized in a neuroendocrine...
journal article 2013
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Poldervaart, M.T. (author), Wang, H. (author), Van der Stok, J. (author), Weinans, H.H. (author), Leeuwenburgh, S.C.G. (author), Cumhur Öner, F. (author), Dhert, W.J.A. (author), Alblas, J. (author)
The design of bioactive three-dimensional (3D) scaffolds is a major focus in bone tissue engineering. Incorporation of growth factors into bioprinted scaffolds offers many new possibilities regarding both biological and architectural properties of the scaffolds. This study investigates whether the sustained release of bone morphogenetic protein...
journal article 2013
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