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Van Oosterom, M.N. (author), Kreuger, R. (author), Buckle, T. (author), Mahn, W.A. (author), Bunschoten, A. (author), Josephson, L. (author), Van Leeuwen, F.W.B. (author), Beekman, F.J. (author)Background: In vivo bioluminescence, fluorescence, and single-photon emission computed tomography (SPECT) imaging provide complementary information about biological processes. However, to date these signatures are evaluated separately on individual preclinical systems. In this paper, we introduce a fully integrated bioluminescence-fluorescence...journal article 2014
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Branderhorst, W. (author), Vastenhouw, B. (author), Van der Have, F. (author), Blezer, E.L.A. (author), Bleeker, W.K. (author), Beekman, F.J. (author)Purpose: Small-animal single photon emission computed tomography (SPECT) with focused multi-pinhole collimation geometries allows scanning modes in which large amounts of photons can be collected from specific volumes of interest. Here we present new tools that improve targeted imaging of specific organs and tumours, and validate the effects of...journal article 2010
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Wu, C. (author), Van der Have, F. (author), Vastenhouw, B. (author), Dierckx, R.A.J.O. (author), Paans, A.M.J. (author), Beekman, F.J. (author)Purpose: In pinhole SPECT, attenuation of the photon flux on trajectories between source and pinholes affects quantitative accuracy of reconstructed images. Previously we introduced iterative methods that compensate for image degrading effects of detector and pinhole blurring, pinhole sensitivity and scatter for multi-pinhole SPECT. The aim of...journal article 2010
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Golestani, R. (author), Wu, C. (author), Tio, R.A. (author), Zeebregts, C.J. (author), Petrov, A.D. (author), Beekman, F.J. (author), Dierckx, R.A.J.O. (author), Boersma, H.H. (author), Slart, R.H.J.A. (author)Preclinical cardiovascular research using noninvasive radionuclide and hybrid imaging systems has been extensively developed in recent years. Single photon emission computed tomography (SPECT) is based on the molecular tracer principle and is an established tool in noninvasive imaging. SPECT uses gamma cameras and collimators to form projection...journal article 2010
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- Xiao, J. (author), Verzijlbergen, F.J. (author), Viergever, M.A. (author), Beekman, F.J. (author) journal article 2009
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Esme, D.L. (author), Bucksch, A. (author), Beekman, W.H. (author)Background Three-dimensional (3D) terrestrial laser scanning (TLS) is a valuable method for measuring shapes of objects and for obtaining quantitative measurements. These qualities of the 3D laser scanner have proved to be useful in reconstructive breast surgery. This study investigated various 3D parameters to obtain an optimal objective...journal article 2008
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Jongen, C. (author), De Bruin, K. (author), Beekman, F.J. (author), Booij, J. (author)Purpose: The dopamine D2 receptor (D2R) is important in the mediation of addiction. [123I]iodobenzamide (IBZM), a SPECT ligand for the D2R, has been used for in vivo studies of D2R availability in humans, monkeys, and rats. Although mouse models are important in the study of addiction, [123I]IBZM has not been used in mice SPECT studies. This...journal article 2008
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Degradation of myocardial perfusion SPECT images caused by contaminants in thallous (201Tl) chlorideStaelens, S.G. (author), De Wit, T.C. (author), Lemahieu, I.A. (author), Beekman, F.J. (author)Purpose Thallous (201Tl) chloride is a single-photon emission computed tomography (SPECT) tracer mainly used for assessing perfusion and viability of myocardial tissue. 201Tl emits X-rays around 72 keV and gammas at 167 keV, and has a half-life of 73 h. Regulations allow an intrinsic contamination up to 3–5%, which is mainly caused by 200Tl (368...journal article 2008
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Beekman, F.J. (author), Hutton, B.F. (author)Editorial commentary.journal article 2007