Predicting the Efficacy of Stalk Cells Following Leading Cells Through a Micro-Channel Using Morphoelasticity and a Cell Shape Evolution Model

Cancer cell migration between different body parts is the driving force behind cancer metastasis, which causes mortality of patients. Migration of cancer cells often proceeds by penetration through narrow cavities in possibly stiff tissues. In our previous work [12], a model for the evolution of cell geometry is developed, and in the current...

Upscaling between an agent-based model (smoothed particle approach) and a continuum-based model for skin contractions

Skin contraction is an important biophysical process that takes place during and after recovery of deep tissue injury. This process is mainly caused by fibroblasts (skin cells) and myofibroblasts (differentiated fibroblasts which exert larger pulling forces and produce larger amounts of collagen) that both exert pulling forces on the...

A formalism for modelling traction forces and cell shape evolution during cell migration in various biomedical processes

The phenomenological model for cell shape deformation and cell migration Chen (BMM 17:1429–1450, 2018), Vermolen and Gefen (BMM 12:301–323, 2012), is extended with the incorporation of cell traction forces and the evolution of cell equilibrium shapes as a result of cell differentiation. Plastic deformations of the extracellular matrix are...

Agent-based modelling and parameter sensitivity analysis with a finite-element method for skin contraction

In this paper, we extend the model of wound healing by Boon et al. (J Biomech 49(8):1388–1401, 2016). In addition to explaining the model explicitly regarding every component, namely cells, signalling molecules and tissue bundles, we categorized fibroblasts as regular fibroblasts and myofibroblasts. We do so since it is widely documented that...