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Frkatović-Hodžić, Azra (author), Mijakovac, Anika (author), Miškec, Karlo (author), Nostaeva, Arina (author), Sharapov, Sodbo Z. (author), Landini, Arianna (author), Haller, Toomas (author), van den Akker, E.B. (author), Sharma, Sapna (author)
Glycans are an essential structural component of immunoglobulin G (IgG) that modulate its structure and function. However, regulatory mechanisms behind this complex posttranslational modification are not well known. Previous genome-wide association studies (GWAS) identified 29 genomic regions involved in regulation of IgG glycosylation, but...
journal article 2023
Bizzarri, D. (author), Reinders, M.J.T. (author), Beekman, M. (author), Slagboom, P. E. (author), van den Akker, E.B. (author)
Background: Missing or incomplete phenotypic information can severely deteriorate the statistical power in epidemiological studies. High-throughput quantification of small-molecules in bio-samples, i.e. ‘metabolomics’, is steadily gaining popularity, as it is highly informative for various phenotypical characteristics. Here we aim to leverage...
journal article 2022
Roshchupkin, G. V. (author), Adams, H. H H (author), Vernooij, M. W. (author), Hofman, A. (author), Van Duijn, C. M. (author), Ikram, M. A. (author), Niessen, W.J. (author)
High-throughput technology can now provide rich information on a person's biological makeup and environmental surroundings. Important discoveries have been made by relating these data to various health outcomes in fields such as genomics, proteomics, and medical imaging. However, cross-investigations between several high-throughput...
journal article 2016