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Suresan, Anjali (author)Atrial Fibrillation (AF) is a cardiac arrhythmia that occurs due to the initiation of electrical impulses in the heart in an uncoordinated manner, giving rise to a disorganized and rapid heartbeat. The progression of AF over time can lead to complications such as stroke and heart failure. Catheter ablation is an established treatment protocol...master thesis 2023
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Licurici, Teodor (author)Estimating the transmembrane currents travelling through the epicardium and local activation times based on atrial epicardial electrograms can greatly help in the study of cardiac arrhythmias such as atrial fibrillation. This work focuses on the accurate estimation of the aforementioned signals and features. To do this, two least squares-based...master thesis 2023
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Rodewijk, Koen (author)Atrial fibrillation (AF) is the most commonly occurring arrhythmia in clinical practice and can have a significant impact on the current and future wellbeing of the patient. By placing an unipolar sensor array directly on the epicardium during an open-heart surgery to measure the electrical activity of the atrium, more insight about this disease...master thesis 2023
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Wenink, Kristel (author)Introduction: Currently, there is no method available for intra-operative evaluation of the completeness (transmurality and continuity) of surgical ablation lesions. This study aimed to investigate the changes in electrogram characteristics and activation patterns caused by different (non)transmural and (dis)continuous ablation lesions in ex...master thesis 2023
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van Schie, M.S. (author), Liao, Rongheng (author), Ramdat Misier, Nawin L. (author), Knops, Paul (author), Heida, Annejet (author), Taverne, Yannick J.H.J. (author), de Groot, N.M.S. (author)BACKGROUND AND AIMS: Atrial extrasystoles (AES) provoke conduction disorders and may trigger episodes of atrial fibrillation (AF). However, the direction- and rate-dependency of electrophysiological tissue properties on epicardial unipolar electrogram (EGM) morphology is unknown. Therefore, this study examined the impact of spontaneous AES on...journal article 2023
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de Vries, J.W. (author), Sun, M. (author), de Groot, N.M.S. (author), Hendriks, R.C. (author)Estimating tissue conductivity parameters from electrograms (EGMs) could be an important tool for diagnosing and treating heart rhythm disorders such as atrial fibrillation (AF). One of these parameters is the fibre direction, often assumed to be known in conductivity estimation methods. In this paper, a novel method to estimate the fibre...conference paper 2023
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Nyns, Emile C.A. (author), Portero, Vincent (author), Deng, Shanliang (author), Jin, T. (author), Harlaar, Niels (author), Bart, Cindy I. (author), van Brakel, Thomas J. (author), Palmen, Meindert (author), Hjortnaes, Jesper (author), Ramkisoensing, Arti A. (author), Zhang, Kouchi (author), Poelma, René H. (author), Ördög, Balázs (author), de Vries, Antoine A.F. (author), Pijnappels, Daniël A. (author)Background: Optogenetics could offer a solution to the current lack of an ambulatory method for the rapid automated cardioversion of atrial fibrillation (AF), but key translational aspects remain to be studied. Objective: To investigate whether optogenetic cardioversion of AF is effective in the aged heart and whether sufficient light...journal article 2023
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van Staveren, Lianne N. (author), Hendriks, R.C. (author), Taverne, Yannick J.H.J. (author), de Groot, N.M.S. (author)Background: Dominant frequencies (DFs) or complex fractionated atrial electrograms (CFAEs), indicative of focal sources or rotational activation, are used to identify target sites for atrial fibrillation (AF) ablation in clinical studies, although the relationship among DF, CFAE, and activation patterns remains unclear. Objectives: This study...journal article 2023
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Schram Serban, Corina (author), de Groot, N.M.S. (author)(1) Background. Obesity is a well-established worldwide recognised risk factor for atrial fibrillation (AF). Prior review papers reported on the associations between obesity and AF development, but not on the relation between obesity and atrial electrophysiology. We therefore conducted a systematic review to describe the current knowledge of...review 2023
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Veen, Danny (author), Verbeek, Eva C. (author), Kavousi, Maryam (author), Huigen, Jos (author), Mijnen-Schra, Annet (author), Cocchieri, Riccardo (author), Khan, Muchtiar (author), de Groot, N.M.S. (author)Background: Prior studies demonstrated that female sex is associated with arrhythmia recurrence after endovascular pulmonary vein isolation (PVI). However, it is unknown if the sexes differ in outcome after video assisted thoracoscopic (VATS) PVI. The aim of this study was therefore to compare characteristics of recurrent AF episodes in a...journal article 2023
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Hunter, William (author)Atrial fibrillation is a common cardiovascular disease, affecting the regular beating of the heart through chaotic contraction of the heart's upper chambers. On its own, the condition—increasingly prevalent among the elderly—is not life threatening, but it leads to an increased risk of stroke and heart failure. As of yet, there is no consensus...master thesis 2022
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Kos, Cees (author)The heart is one of our vital organs. It functions by periodically contracting in a rhythmic way. Sometimes, this rhythmic behaviour is affected by abnormalities in the tissue. These conditions are referred to as cardiac arrhythmias. One kind is of specific interest, called atrial fibrillation (AF). To further study AF, methods have been...master thesis 2022
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Sun, M. (author)Atrial fibrillation (AF) is a frequently encountered cardiac arrhythmia characterized by rapid and irregular atrial activity, which increases the risk of strokes, heart failure and other heart-related complications. The mechanisms of AF are complicated. Although various mechanisms were proposed in previous research, the precise mechanisms of AF...doctoral thesis 2022
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Moree, Tijs (author)The most common serious heart rhythm disease is atrial fibrillation. It is not fatal on its own but does increase the risk of heart failures and strokes. There is little understanding about the mechanisms behind the disease, so more insight is desired. Using an array of electrodes, measurements are being performed of the electrical atrial...master thesis 2022
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Moghaddasi Kelishomi, H. (author), Hendriks, R.C. (author), van der Veen, A.J. (author), de Groot, N.M.S. (author), Hunyadi, Borbala (author)Atrial fibrillation (AF) is the most sustained arrhythmia in the heart and also the most common complication developed after cardiac surgery. Due to its progressive nature, timely detection of AF is important. Currently, physicians use a surface electrocardiogram (ECG) for AF diagnosis. However, when the patient develops AF, its various...journal article 2022
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Wesselius, F.J. (author), van Schie, M.S. (author), de Groot, N.M.S. (author), Hendriks, R.C. (author)Background: An increasing number of wearables are capable of measuring electrocardiograms (ECGs), which may help in early detection of atrial fibrillation (AF). Therefore, many studies focus on automated detection of AF in ECGs. A major obstacle is the required amount of manually labelled data. This study aimed to provide an efficient and...journal article 2022
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Tenbult, Nicole (author), Kraal, J.J. (author), Brouwers, Rutger (author), Spee, Ruud (author), Eijsbouts, Sabine (author), Kemps, Hareld (author)Background: Atrial fibrillation is commonly associated with obesity. Observational studies have shown that weight loss is associated with improved prognosis and a decrease in atrial fibrillation frequency and severity. However, despite these benefits, nonadherence to lifestyle programs is common. Objective: In this study, we evaluated adherence...journal article 2022
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de Groot, N.M.S. (author), Shah, Dipen (author), Boyle, Patrick M. (author), Anter, Elad (author), Clifford, Gari D. (author), Deisenhofer, Isabel (author), van Dessel, Pascal (author), Dilaveris, Polychronis (author), van der Veen, A.J. (author)We aim to provide a critical appraisal of basic concepts underlying signal recording and processing technologies applied for (i) atrial fibrillation (AF) mapping to unravel AF mechanisms and/or identifying target sites for AF therapy and (ii) AF detection, to optimize usage of technologies, stimulate research aimed at closing knowledge gaps,...journal article 2022
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Roest, Jeroen (author)Introduction: Potentials measured at the epicardial surface contain information regarding the conductive properties of the atrial tissue. The current lack of morphological categorization during atrial fibrillation (AF) provokes the usage of unsupervised learning methods to evaluate time series electrograms across the atrial surface. Analysis of...master thesis 2021
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Abdi, Bahareh (author)Atrial fibrillation (AF) is a common age-related cardiac arrhythmia. AF is characterized by rapid and irregular electrical activity of the heart leading to a higher risk of stroke and heart failure. During AF, the upper chambers of the heart, called atria, experience chaotic electrical wave propagation. However, despite the various mechanisms...doctoral thesis 2021
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