Searched for: subject:"Bioinformatics"
(1 - 14 of 14)
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van Dijk, Mick (author)
Global medical use of azole antifungals and echinocandins has led to an enormous increase in resistant Candida species, that are most commonly associated with fungal infections. A possible mechanism causing resistance are single or simultaneous point mutations in the genes responsible for encoding antifungal target enzymes. The aim of...
master thesis 2019
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Uljee, Jasper (author), de Vries, Yorick (author)
Accurate diagnosis and treatment of patients infected with multiple strains of a pathogen is a challenging task. The use of whole genome sequencing techniques provide high potential to give proper insight into the microbial composition of human metagenomic samples. Distinguishing multiple strains of a certain species is difficult due to the high...
bachelor thesis 2018
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van Dijk, Lucas (author)
Capturing all genetic variation within a polyploid organism is a challenge. Most current de novo assemblers have no notion of the concept “ploidy”. Consequently, when assembling the genome of diploid or higher ploidy organisms, the assembler mixes reads coming from either chromosome copy and builds a single DNA sequence representing an arbitrary...
master thesis 2017
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Thomaidou, Eftychia (author)
In this research, we studied the impact of the 5'UTR sequences on translation. This is done by generating various features describing the 5'UTR. Those features are then used as input in regression and classification models, that have the Translation Initiation Rates as target. The reason why it is of such importance, is dual. Because is very...
master thesis 2017
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Timal, N.R.N. (author)
Detecting similarities between (RNA, DNA, and protein) sequences is an important part of bioinformatics. Among the algorithms used to accomplish this, the Smith-Waterman algorithm is very popular. A sequential implementation of Smith-Waterman requires quadratic running time with respect to the length of the sequences. As the amount of data in...
master thesis 2015
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Patsis, K. (author)
The goal of this study was to dive into the novel techniques associated with the use of the available Third Generation DNA Sequencing (TGS) platform, PacBio. This 3-year old technology sounded promising right from the beginning but its groundbreaking attributes, like length and error content, required unconventional handling to yield worthwhile...
master thesis 2014
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Yao, Y. (author)
A single-molecule protein sequencer, which labels only 2 out of 20 amino acids and uses single-molecule TIRF microscopy to measure the order of these fingerprints, opens the door to identify proteins with high fidelity using only a small quantity of sample. From the fingerprint, a key challenge is to detect which protein was measured. We present...
master thesis 2014
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Palachanis, D. (author)
Cell differentiation is a natural process occurring in all higher organisms, since the early fetal stage of life. It is, also, a part of disease – such as cancer – as the cell cycle becomes deregulated and cells behave differently compared to healthy ones. Differentiation occurs although the genome of all cells is identical across all cell types...
master thesis 2014
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Straver, R. (author)
Motivation: Numerous genetic disorders can be detected in prenatal diagnosis using Chorionic Villus Sampling. As this brings a 1:100 chance for miscarriage, this method is only applied when the fetus is suspected to have an increased chance at having an aberration. It is known that a small percentage of DNA in maternal plasma is of fetal origin...
master thesis 2012
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De Ruiter, J.R. (author), Melman, C. (author), Korstanje, R. (author), Dentro, S. (author), Aben, N. (author)
This document is the final report describing the development process of a graphical, statistical analysis application of copy number variations in aCGH data. The document is intended to provide an insight in the development process used to produce the final prototype delivered by the project. The project entailed the design and implementation of...
bachelor thesis 2010
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Houtgast, E.J. (author)
Exponential growth in biological sequence data combined with the computationally intensive nature of bioinformatics applications results in a continuously rising demand for processing power. Microprocessor complexity and, more importantly, computational capability increases as well, through transistor budgets that grow in line with Moore's law....
master thesis 2009
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Van den Berg, B.A. (author)
Motivation: Synthetic biology aims at building biological systems for useful purposes. Relatively simple gene networks have been engineered, but the design process is limited. Many papers advocate the use of engineering concepts like standardization and modular design to simplify the design process and enable the design of more complex systems....
master thesis 2009
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Van Rijk, E. (author)
With the rise of multi-core chips in commodity hardware, the need for specialized workloads to evaluate the performance of multi-core systems has become apparent. The current generation of workloads used for evaluating multi-core systems often consist of sequential programs not capable of running on multiple processors and are therefore of...
master thesis 2009
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Van den Haak, P. (author), Cheung, M. (author)
Major research efforts in Bioinformatics include sequence alignment, gene finding, genome assembly, protein structure alignment, protein structure prediction, prediction of gene expression and protein-protein interactions, and the modeling of evolution. To perform these specific tasks different tools are used. Using these tools separately is a...
bachelor thesis 2008
Searched for: subject:"Bioinformatics"
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