Searched for: subject%3A%22Cell%255C%252BBE%22
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Eijkel, B.I.M. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)
The antibacterial biofunctionality of bone implants is essential for the prevention and treatment of implant-associated infections (IAI). In vitro co-culture models are utilized to assess this and study bacteria-host cell interactions at the implant interface, aiding our understanding of biomaterial and the immune response against IAI without...
review 2024
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Blöbaum, Luisa (author), Haringa, C. (author), Grünberger, Alexander (author)
Bioprocesses are scaled up for the production of large product quantities. With larger fermenter volumes, mixing becomes increasingly inefficient and environmental gradients get more prominent than in smaller scales. Environmental gradients have an impact on the microorganism's metabolism, which makes the prediction of large-scale performance...
review 2023
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Blanch Jover, A. (author), Dekker, C. (author)
The Cdv system is the protein machinery that performs cell division and other membrane-deforming processes in a subset of archaea. Evolutionarily, the system is closely related to the eukaryotic ESCRT machinery, with which it shares many structural and functional similarities. Since its first description 15 years ago, the understanding of the...
review 2023
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Zhou, Liangbin (author), Xu, J. (author), Schwab, Andrea (author), Tong, Wenxue (author), Zheng, Lizhen (author), Li, Zhuo (author), Xu, Shunxiang (author), van Osch, G.J.V.M. (author), Wen, Chunyi (author), Qin, Ling (author)
As a highly specialized shock-absorbing connective tissue, articular cartilage (AC) has very limited self-repair capacity after traumatic injuries, posing a heavy socioeconomic burden. Common clinical therapies for small- to medium-size focal AC defects are well-developed endogenous repair and cell-based strategies, including microfracture,...
review 2023
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Cordes, Martijn (author), Pike-Overzet, K. (author), van den Akker, E.B. (author), Staal, F.J.T. (author), Canté-Barrett, Kirsten (author)
Traditionally, flow cytometry has been the preferred method to characterize immune cells at the single-cell level. Flow cytometry is used in immunology mostly to measure the expression of identifying markers on the cell surface, but—with good antibodies—can also be used to assess the expression of intracellular proteins. The advent of single...
review 2023
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Yarali, E. (author), Zadpoor, A.A. (author), Staufer, U. (author), Accardo, A. (author), Mirzaali, Mohammad J. (author)
Mechanical and morphological design parameters, such as stiffness or porosity, play important roles in creating orthopedic implants and bone substitutes. However, we have only a limited understanding of how the microarchitecture of porous scaffolds contributes to bone regeneration. Meta-biomaterials are increasingly used to precisely engineer...
review 2023
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Van de Cauter, L. (author), van Buren, L. (author), Koenderink, G.H. (author), Ganzinger, Kristina A. (author)
Creating an artificial cell from the bottom up is a long-standing challenge and, while significant progress has been made, the full realization of this goal remains elusive. Arguably, one of the biggest hurdles that researchers are facing now is the assembly of different modules of cell function inside a single container. Giant unilamellar...
review 2023
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Velot, Émilie (author), Balmayor, Elizabeth R. (author), Bertoni, Lélia (author), Chubinskaya, Susan (author), Cicuttini, Flavia (author), de Girolamo, Laura (author), Demoor, Magali (author), van Osch, G.J.V.M. (author), Cucchiarini, Magali (author)
review 2023
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Castillo Ransanz, Lucía (author), van Altena, P.F.J. (author), Heine, Vivi M. (author), Accardo, A. (author)
The biomechanical properties of the brain microenvironment, which is composed of different neural cell types, the extracellular matrix, and blood vessels, are critical for normal brain development and neural functioning. Stiffness, viscoelasticity and spatial organization of brain tissue modulate proliferation, migration, differentiation, and...
review 2022
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Koster, C.C. (author), Postma, E.D. (author), Knibbe, E. (author), Cleij, C.V. (author), Daran-Lapujade, P.A.S. (author)
Synthetic Genomics focuses on the construction of rationally designed chromosomes and genomes and offers novel approaches to study biology and to construct synthetic cell factories. Currently, progress in Synthetic Genomics is hindered by the inability to synthesize DNA molecules longer than a few hundred base pairs, while the size of the...
review 2022
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Brycht, Mariola (author), Poltorak, Lukasz (author), Baluchová, S. (author), Sipa, Karolina (author), Borgul, Paulina (author), Rudnicki, Konrad (author), Skrzypek, Sławomira (author)
Cancer is most frequently treated with antineoplastic agents (ANAs) that are hazardous to patients undergoing chemotherapy and the healthcare workers who handle ANAs in the course of their duties. All aspects related to hazardous oncological drugs illustrate that the monitoring of ANAs is essential to minimize the risks associated with these...
review 2022
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Mehta, P.P. (author), Rahman, Z. (author), ten Dijke, Peter (author), Boukany, P. (author)
An early step of metastasis requires a complex and coordinated migration of invasive tumor cells into the surrounding tumor microenvironment (TME), which contains extracellular matrix (ECM). It is being appreciated that 3D matrix-based microfluidic models have an advantage over conventional in vitro and animal models to study tumor...
review 2022
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Fan, Liyuan (author), Li, Chao'en (author), van Biert, L. (author), Zhou, Shou Han (author), Tabish, Asif Nadeem (author), Mokhov, Anatoli (author), Aravind, Purushothaman Vellayani (author), Cai, Weiwei (author)
With the demand for anticipated green hydrogen and power production, novel and upgraded catalytic processes are desired for more effective utilization of precious natural resources. Methane steam reforming is an advanced and matured technology for converting methane to hydrogen and syngas. As a renewable energy resource containing a large...
review 2022
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Faraj, Noura (author), Duinkerken, B. H.Peter (author), Carroll, E.C.M. (author), Giepmans, Ben N.G. (author)
Microscopic analysis of molecules and physiology in living cells and systems is a powerful tool in life sciences. While in vivo subcellular microscopic analysis of healthy and diseased human organs remains impossible, zebrafish larvae allow studying pathophysiology of many organs using in vivo microscopy. Here, we review the potential of the...
review 2022
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Baldauf, L. (author), van Buren, L. (author), Fanalista, F. (author), Koenderink, G.H. (author)
One of the major challenges of bottom-up synthetic biology is rebuilding a minimal cell division machinery. From a reconstitution perspective, the animal cell division apparatus is mechanically the simplest and therefore attractive to rebuild. An actin-based ring produces contractile force to constrict the membrane. By contrast, microbes and...
review 2022
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Birnie, Anthony (author), Dekker, C. (author)
Chromosome structure and dynamics are essential for life, as the way that our genomes are spatially organized within cells is crucial for gene expression, differentiation, and genome transfer to daughter cells. There is a wide variety of methods available to study chromosomes, ranging from live-cell studies to single-molecule biophysics,...
review 2021
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Barata-Antunes, Cláudia (author), Alves, Rosana (author), Talaia, Gabriel (author), Casal, Margarida (author), Gerós, Hernâni (author), Mans, R. (author), Paiva, Sandra (author)
Plasma membrane transporters play pivotal roles in the import of nutrients, including sugars, amino acids, nucleobases, carboxylic acids, and metal ions, that surround fungal cells. The selective removal of these transporters by endocytosis is one of the most important regulatory mechanisms that ensures a rapid adaptation of cells to the...
review 2021
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Betjes, M.A. (author), Zheng, X.Z. (author), Kok, R.N.U. (author), van Zon, Jeroen S. (author), Tans, S.J. (author)
Organoids have emerged as powerful model systems to study organ development and regeneration at the cellular level. Recently developed microscopy techniques that track individual cells through space and time hold great promise to elucidate the organizational principles of organs and organoids. Applied extensively in the past decade to embryo...
review 2021
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Boot, R.C. (author), Koenderink, G.H. (author), Boukany, P. (author)
Spheroids are widely used in vitro 3D multicellular model systems that mimic complex physiological microenvironments of tissues. As different cell types vary in deformability and adhesion, the choice of (heterogeneous) cell composition will define overall spheroid mechanics, including their viscoelasticity and effective surface tension. These...
review 2021
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van Wee, R.G. (author), Filius, M. (author), Joo, C. (author)
Single-molecule localization microscopy (SMLM) is a potent tool to examine biological systems with unprecedented resolution, enabling the investigation of increasingly smaller structures. At the forefront of these developments is DNA-based point accumulation for imaging in nanoscale topography (DNA-PAINT), which exploits the stochastic and...
review 2021
Searched for: subject%3A%22Cell%255C%252BBE%22
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