Searched for: subject%3A%22Cell%255C+BE%22
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Godino, E. (author), Danelon, C.J.A. (author)
Mimicking bacterial cell division in well-defined cell-free systems has the potential to elucidate the minimal set of proteins required for cytoskeletal formation, membrane constriction, and final abscission. Membrane-anchored FtsZ polymers are often regarded as a sufficient system to realize this chain of events. By using purified FtsZ and...
journal article 2023
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Sakata, Dousatsu (author), Hirayama, Ryoichi (author), Shin, Wook Geun (author), Belli, Mauro (author), Tabocchini, Maria A. (author), Stewart, Robert D. (author), Brown, J.M.C. (author), Kyriakou, G.I. (author), Tran, Hoang N. (author)
Purpose: Track structure Monte Carlo (MC) codes have achieved successful outcomes in the quantitative investigation of radiation-induced initial DNA damage. The aim of the present study is to extend a Geant4-DNA radiobiological application by incorporating a feature allowing for the prediction of DNA rejoining kinetics and corresponding cell...
journal article 2023
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van Veldhuizen, B.N. (author), van Biert, L. (author), Amladi, A. (author), Woudstra, T. (author), Visser, K. (author), Aravind, P.V. (author)
An increasing demand in the marine industry to reduce emissions led to investigations into more efficient power conversion using fuels with sustainable production pathways. Solid Oxide Fuel Cells (SOFCs) are under consideration for long-range shipping, because of its high efficiency, low pollutant emissions, and fuel flexibility. SOFC systems...
journal article 2023
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Zhang, Yuxuan (author), Zhai, Xiaoqiang (author), Zhang, Fengyuan (author), Zhang, Zhongbin (author), Hooman, K. (author), Zhang, Hai (author), Wang, Xiaolin (author)
Enhancing gas-liquid mass transfer is key to promote gas hydrate formation kinetics. Encapsulation of CO<sub>2</sub> hydrate is expected to dramatically increase gas-liquid contact to enhance mass transfer. However, gas hydrate encapsulation has never been proposed as the technical issues of gas permeation through capsule shells have never...
journal article 2023
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Blanch Jover, A. (author), Dekker, C. (author)
The Cdv system is the protein machinery that performs cell division and other membrane-deforming processes in a subset of archaea. Evolutionarily, the system is closely related to the eukaryotic ESCRT machinery, with which it shares many structural and functional similarities. Since its first description 15 years ago, the understanding of the...
review 2023
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van der Sluis, Tetje C. (author), Beyrend, Guillaume (author), van der Gracht, Esmé T.I. (author), Abdelaal, T.R.M. (author), Jochems, Simon P. (author), Belderbos, Robert A. (author), Wesselink, Thomas H. (author), van Duikeren, Suzanne (author), Arens, Ramon (author)
Immune checkpoint therapy (ICT) has the power to eradicate cancer, but the mechanisms that determine effective therapy-induced immune responses are not fully understood. Here, using high-dimensional single-cell profiling, we interrogate whether the landscape of T cell states in the peripheral blood predict responses to combinatorial targeting...
journal article 2023
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Liu, H. (author), Nadar, R.A. (author), Fauzia, R.P. (author), Laan, A.C. (author), Wang, R. (author), van Cooten, Quenteijn (author), Carroll, E.C.M. (author), Eelkema, R. (author), Denkova, A.G. (author)
Combination of therapies is a common strategy in cancer treatment. Such combined therapies only have merit provided that there is superior therapeutic outcome with fewer side effects, compared to single therapies. Here, this work explores the possibility to combine chemotherapy with radionuclide therapy using polymeric micelles as a delivery...
journal article 2023
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Sharaf, A.M.S.E. (author), Frimat, J. P. (author), Kremers, G. J. (author), Accardo, A. (author)
Two-photon polymerization (2PP) has provided the field of cell biology with the opportunity to fabricate precisely designed microscaffolds for a wide range of studies, from mechanobiology to in vitro disease modelling. However, a multitude of commercial and in-house developed photosensitive materials employed in 2PP suffers from high auto...
journal article 2023
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Zhou, Liangbin (author), Xu, J. (author), Schwab, Andrea (author), Tong, Wenxue (author), Zheng, Lizhen (author), Li, Zhuo (author), Xu, Shunxiang (author), van Osch, G.J.V.M. (author), Wen, Chunyi (author), Qin, Ling (author)
As a highly specialized shock-absorbing connective tissue, articular cartilage (AC) has very limited self-repair capacity after traumatic injuries, posing a heavy socioeconomic burden. Common clinical therapies for small- to medium-size focal AC defects are well-developed endogenous repair and cell-based strategies, including microfracture,...
review 2023
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Cordes, Martijn (author), Pike-Overzet, K. (author), van den Akker, E.B. (author), Staal, F.J.T. (author), Canté-Barrett, Kirsten (author)
Traditionally, flow cytometry has been the preferred method to characterize immune cells at the single-cell level. Flow cytometry is used in immunology mostly to measure the expression of identifying markers on the cell surface, but—with good antibodies—can also be used to assess the expression of intracellular proteins. The advent of single...
review 2023
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da Silva, Renan F. (author), Hansen, Jeff E. (author), Lowe, Ryan J. (author), Rijnsdorp, D.P. (author), Buckley, Mark L. (author)
Nearshore rocky reefs with scales of order 10–100 m are common along the world's coastline and often shape wave-driven hydrodynamics and shoreline morphology in their lee. The interaction of waves with these reefs generally results in either two or four-cell mean circulation systems (2CC and 4CC, respectively), with diverging flows behind the...
journal article 2023
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Ji, Encheng (author), Leijsten, Lieke (author), Witte-Bouma, Janneke (author), Rouchon, Adelin (author), Di Maggio, Nunzia (author), Banfi, Andrea (author), van Osch, G.J.V.M. (author), Farrell, Eric (author), Lolli, Andrea (author)
Tissue engineering bone via endochondral ossification requires the generation of a cartilage template which undergoes vascularisation and remodelling. While this is a promising route for bone repair, achieving effective cartilage vascularisation remains a challenge. Here, we investigated how mineralisation of tissue-engineered cartilage...
journal article 2023
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Li, L. (author), Lukszo, Z. (author), Schmitz, J.E.J. (author)
Hydrogen is becoming increasingly popular as a clean, secure, and affordable energy source for the future. This study develops an approach for designing a PV–battery–electrolyzer–fuel cell energy system that utilizes hydrogen as a long-term storage medium and battery as a short-term storage medium. The system is designed to supply load demand...
journal article 2023
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Warmink, Kelly (author), Rios, Jaqueline L. (author), Varderidou-Minasian, Suzy (author), Torres-Torrillas, Marta (author), van Valkengoed, Devin R. (author), Versteeg, Sabine (author), Eijkelkamp, Niels (author), Weinans, Harrie (author), Korthagen, Nicoline M. (author), Lorenowicz, Magdalena J. (author)
Background: Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) hold promise as a disease modifying treatment in osteoarthritis (OA). Obesity, and its associated inflammation, contribute to OA development and metabolic OA represents a specific and significant group of the OA patient population. Given their...
journal article 2023
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Stoter, Stein K.F. (author), Divi, Sai C. (author), van Brummelen, E. Harald (author), Larson, Mats G. (author), de Prenter, Frits (author), Verhoosel, Clemens V. (author)
In this article, we study the effect of small-cut elements on the critical time-step size in an immersogeometric explicit dynamics context. We analyze different formulations for second-order (membrane) and fourth-order (shell-type) equations, and derive scaling relations between the critical time-step size and the cut-element size for various...
journal article 2023
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Novella-Rausell, Claudio (author), Grudniewska, Magda (author), Peters, Dorien J.M. (author), Mahfouz, A.M.E.T.A. (author)
The kidney's cellular diversity is on par with its physiological intricacy; yet identifying cell populations and their markers remains challenging. Here, we created a comprehensive atlas of the healthy adult mouse kidney (MKA: Mouse Kidney Atlas) by integrating 140.000 cells and nuclei from 59 publicly available single-cell and single-nuclei...
journal article 2023
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Kapetanović, M. (author), Nunez, Alfredo (author), van Oort, N. (author), Goverde, R.M.P. (author)
Hydrogen fuel cell multiple unit vehicles are acquiring a central role in the transition process towards carbon neutral trains operation in non-electrified regional railway networks. In addition to their primary role as a transport mean, these vehicles offer significant potential for applications in innovative concepts such as smart grids....
journal article 2023
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Kapetanović, M. (author), Nunez, Alfredo (author), van Oort, N. (author), Goverde, R.M.P. (author)
Hydrogen fuel cell multiple unit vehicles are acquiring a central role in the transition process towards carbon neutral trains operation in non-electrified regional railway networks. In addition to their primary role as a transport mean, these vehicles offer significant potential for applications in innovative concepts such as smart grids....
abstract 2023
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Bhadra, A. (author), Haverkort, J.W. (author)
Microfluidic fuel cells, electrolyzers, and redox flow batteries utilize laminar flow channels to provide reactants, remove products and avoid their crossover. These devices often also employ porous flow-through electrodes as they offer a high surface area for the reaction and excellent mass transfer. The geometrical features of these...
journal article 2023
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Disela, R.C. (author), Bussy, Olivier Le (author), Geldhof, Geoffroy (author), Pabst, Martin (author), Ottens, M. (author)
Mass-spectrometry-based proteomics is increasingly employed to monitor purification processes or to detect critical host cell proteins in the final drug substance. This approach is inherently unbiased and can be used to identify individual host cell proteins without prior knowledge. In process development for the purification of new...
journal article 2023
Searched for: subject%3A%22Cell%255C+BE%22
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