Searched for: subject%3A%22Cell%255C+migration%22
(1 - 15 of 15)
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Legerstee, Karin (author), Sueters, J. (author), Abraham, Tsion E. (author), Slotman, Johan A. (author), Kremers, Gert Jan (author), Hoogenboom, J.P. (author), Houtsmuller, A.B. (author)
Focal adhesions (FAs) are the main cellular structures to link the intracellular cytoskeleton to the extracellular matrix. FAs mediate cell adhesion, are important for cell migration and are involved in many (patho)-physiological processes. Here we examined FAs and their associated actin fibres using correlative fluorescence and scanning...
journal article 2022
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Mehta, P.P. (author), Rahman, Z. (author), ten Dijke, Peter (author), Boukany, P. (author)
An early step of metastasis requires a complex and coordinated migration of invasive tumor cells into the surrounding tumor microenvironment (TME), which contains extracellular matrix (ECM). It is being appreciated that 3D matrix-based microfluidic models have an advantage over conventional in vitro and animal models to study tumor...
review 2022
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Sinha, Abhishek (author), Mehta, P.P. (author), Fan, Chuannan (author), Zhang, Jing (author), Marvin, Dieuwke L. (author), van Dinther, Maarten (author), Ritsma, Laila (author), Boukany, P. (author), ten Dijke, Peter (author)
Epithelial to mesenchymal transition (EMT) is crucial during embryonic development, tissue fibrosis, and cancer progression. Epithelial cells that display a cobblestone-like morphology can undergo a switch to mesenchymal-like phenotype, displaying an elongated spindle shape or a fibroblast-like morphology. EMT is characterized by timely and...
book chapter 2022
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Liu, Q. (author), Muralidharan, A. (author), Saateh, A. (author), Ding, Z. (author), ten Dijke, Peter (author), Boukany, P. (author)
In the research of cancer cell invasion and metastasis, recreation of physiologically relevant and faithful three-dimensional (3D) tumor models that recapitulate spatial architecture, spatiotemporal control of cell communication and signaling pathways, and integration of extracellular cues remains an open challenge. Here, a programmable...
journal article 2022
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Klein, Femke (author)
Celmigratie wordt voornamelijk door twee eiwitten veroorzaakt, namelijk Rac en Rho van de Rho-GTPases familie. Deze eiwitten kunnen zowel in actieve als inactieve vorm voorkomen [2], [6], [7]. De actieve vorm is gebonden aan het celmembraan en de inactieve vorm zit los in de cel [7]. De eiwitten kunnen zich verplaatsen in de cel. Doordat de...
bachelor thesis 2021
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Rens, E.G. (author), Edelstein-Keshet, Leah (author)
The small GTPases Rac and Rho are known to regulate eukaryotic cell shape, promoting front protrusion (Rac) or rear retraction (Rho) of the cell edge. Such cell deformation changes the contact and adhesion of cell to the extracellular matrix (ECM), while ECM signaling through integrin receptors also affects GTPase activity. We develop and...
journal article 2021
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Peng, Q. (author), Vermolen, F.J. (author), Weihs, D. (author)
The phenomenological model for cell shape deformation and cell migration Chen (BMM 17:1429–1450, 2018), Vermolen and Gefen (BMM 12:301–323, 2012), is extended with the incorporation of cell traction forces and the evolution of cell equilibrium shapes as a result of cell differentiation. Plastic deformations of the extracellular matrix are...
journal article 2021
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Chen, J. (author), Weihs, Daphne (author), Vermolen, F.J. (author)
More than eighty percent of pancreatic cancer involves ductal adenocarcinoma with an abundant desmoplastic extracellular matrix surrounding the solid tumor entity. This aberrant tumor microenvironment facilitates a strong resistance of pancreatic cancer to medication. Although various therapeutic strategies have been reported to be effective...
journal article 2019
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Kleimann, Eline (author)
Burn injuries can lead to serious complications that have a large influence on someone’s quality of life. In order to help patients, we need to gain insight into the wound healing process and in the development of complications that come with serious burn injuries. The final goal would be to prevent or at least reduce these complications. With a...
master thesis 2018
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Reinders, Firoz (author)
Bone is a tissue with many important functions, such as structural support, organ protection and mineral homeostasis. Additionally, after trauma, it can naturally regenerate into fresh, fully functional bone tissue. However, several factors can significantly impede the healing process and cause the formation of non-union tissue. Costs for...
master thesis 2018
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Cioni, Bianca (author), Nevedomskaya, Ekaterina (author), Melis, Monique H.M. (author), van Burgsteden, Johan (author), Stelloo, Suzan (author), Hodel, Emma (author), Spinozzi, Daniele (author), de Jong, Jeroen (author), Wessels, L.F.A. (author)
Fibroblasts are abundantly present in the prostate tumor microenvironment (TME), including cancer-associated fibroblasts (CAFs) which play a key role in cancer development. Androgen receptor (AR) signaling is the main driver of prostate cancer (PCa) progression, and stromal cells in the TME also express AR. High-grade tumor and poor clinical...
journal article 2018
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Chen, J. (author), Weihs, Daphne (author), Vermolen, F.J. (author)
Cell migration, known as an orchestrated movement of cells, is crucially important for wound healing, tumor growth, immune response as well as other biomedical processes. This paper presents a cell-based model to describe cell migration in non-isotropic fibrin networks around pancreatic tumor islets. This migration is determined by the...
journal article 2017
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Vermolen, F.J. (author), Van der Meijden, R.P. (author), Van Es, M. (author), Gefen, A. (author), Weihs, D. (author)
A phenomenological model is formulated to model the early stages of tumor formation. The model is based on a cell-based formalism, where each cell is represented as a circle or sphere in two-and three dimensional simulations, respectively. The model takes into account constituent cells, such as epithelial cells, tumor cells, and T-cells that...
journal article 2015
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Mul, M.M. (author)
Shape transition of biological cells is simulated by a phenomenological model. The movement of cell walls is caused by its environment. Chemico-mechanically induced cell shape changes are treated with formal mathematical expressions in which lies the originality of this model. Visualizations of output will be presented in order to intuitively...
bachelor thesis 2012
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Vermolen, F.J. (author), Gefen, A. (author)
We consider the movement and viability of individual cells in cell colonies. Cell movement is assumed to take place as a result of sensing the strain energy density as a mechanical stimulus. The model is based on tracking the displacement and viability of each individual cell in a cell colony. Several applications are shown, such as the dynamics...
journal article 2011
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