Searched for: subject:"Co%5C-expression"
(1 - 5 of 5)
document
Zhang, Jinxiong (author), Zhong, Cheng (author), Huang, Yiran (author), Lin, H.X. (author), Wang, Mian (author)
Identifying protein complexes in static protein-protein interaction (PPI) networks is essential for understanding the underlying mechanism of biological processes. Proteins in a complex are co-localized at the same place and co-expressed at the same time. We propose a novel method to identify protein complexes with the features of joint co...
journal article 2019
document
Keo, D.L. (author), Aziz, N. Ahmad (author), Dzyubachyk, Oleh (author), Van Der Grond, Jeroen (author), van Roon-Mom, Willeke M.C. (author), Lelieveldt, B.P.F. (author), Reinders, M.J.T. (author), Mahfouz, A.M.E.T.A. (author)
Cytosine-adenine-guanine (CAG) repeat expansions in the coding regions of nine polyglutamine (polyQ) genes (HTT, ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, ATN1, AR, and TBP) are the cause of several neurodegenerative diseases including Huntington’s disease (HD), six different spinocerebellar ataxias (SCAs), dentatorubral-pallidoluysian atrophy, and...
journal article 2017
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Mahfouz, A.M.E.T.A. (author), Huisman, S.M.H. (author), Lelieveldt, B.P.F. (author), Reinders, M.J.T. (author)
The immense complexity of the mammalian brain is largely reflected in the underlying molecular signatures of its billions of cells. Brain transcriptome atlases provide valuable insights into gene expression patterns across different brain areas throughout the course of development. Such atlases allow researchers to probe the molecular mechanisms...
journal article 2017
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Mahfouz, A. (author), Ziats, M.N. (author), Rennert, O.M. (author), Lelieveldt, B.P.F. (author), Reinders, M.J.T. (author)
Autism spectrum disorder (ASD) is a neurodevelopmental syndrome known to have a significant but complex genetic etiology. Hundreds of diverse genes have been implicated in ASD; yet understanding how many genes, each with disparate function, can all be linked to a single clinical phenotype remains unclear. We hypothesized that understanding...
journal article 2015
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Van den Brink, L.O. (author)
The developing human brain is a complex process, governed by the human genome. Understanding this development process is the key to understanding not only the connections between genes and brain functioning, but can also advance knowledge about disorders such as Alzheimer’s and Autism. The BrainSpan transcriptional atlas, released in 2013 by the...
master thesis 2014
Searched for: subject:"Co%5C-expression"
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