Technology platform for advanced neurostimulation implants: The “chip-in-tip” DBS probe

The progress in the field of neurostimulation is impressive, both from a technical as well as from a therapeutic point of view. Nowadays, the electrical stimulation of the nervous system can be used to induce or suppress muscle responses. Additionally, it can also influence hearing, vision, immune system response, pain perception, and even...

Spatial versus angular resolution for tractography-assisted planning of deep brain stimulation

Given the restricted total scanning time for clinical neuroimaging, it is unclear whether clinical diffusion MRI protocols would benefit more from higher spatial resolution or higher angular resolution. In this work, we investigated the relative benefit of improving spatial or angular resolution in diffusion MRI to separate two parallel...

Lamb Waves and Adaptive Beamforming for Aberration Correction in Medical Ultrasound Imaging

Phase aberration in transcranial ultrasound imaging (TUI) caused by the human skull leads to an inaccurate image reconstruction. In this article, we present a novel method for estimating the speed of sound and an adaptive beamforming technique for phase aberration correction in a flat polyvinylchloride (PVC) slab as a model for the human...

The effectiveness of deep brain stimulation in improving upper and lower extremity function under dual task conditions in Parkinson?’s disease patients

Parkinson?’s disease (PD) is a progressive neurodegenerative disorder characterized by reduced movement. Postural instability and gait dysfunction (PIGD) is one of the more debilitating symptoms of PD due to its effect on activities of daily life and increased risk for falls. In later stages of the disease, cognitive impairment affects executive...

A versatile output stage for implantable neural stimulators

Neural stimulators have the potential of becoming very important devices for the treatment of a wide variety of diseases. One of the major problems with existing stimulators is the limited waveform adjustability. This precludes the use of sophisticated stimulation programs and thereby affects the efficacy of the therapy applied. Another issue is...