Aging does not change the compressive stiffness of mandibular condylar cartilage in horses

Objective: Aging can cause an increase in the stiffness of hyaline cartilage as a consequence of increased protein crosslinks. By induction of crosslinking, a reduction in the diffusion of solutions into the hyaline cartilage has been observed. However, there is a lack of knowledge about the effects of aging on the biophysical and biochemical...

Multi-physics computational models of articular cartilage for estimation of its mechanical and physical properties

Recent advances in the realm of computational modeling of complex multiphysics phenomena in articular cartilage enabled efficient and precise determination of articular cartilage properties. However, still accurate quantification of complicated indentation and diffusion processes tying closely with the inhomogeneity of articular cartilage...

Combined inverse-forward artificial neural networks for fast and accurate estimation of the diffusion coefficients of cartilage based on multi-physics models

Analytical and numerical methods have been used to extract essential engineering parameters such as elastic modulus, Poisson's ratio, permeability and diffusion coefficient from experimental data in various types of biological tissues. The major limitation associated with analytical techniques is that they are often only applicable to problems...