Impaired Theta-Gamma Coupling as Biomarker for a Mouse Model of Dravet Syndrome

Dravet Syndrome is a rare epileptic disorder, which is caused in more than 70% of all patients by a loss-of-function mutation in the SCN1A gene encoding sodium channel Nav1.1. One of the main problems for treatment of patients with Dravet Syndrome is drug resistance and there are no biomarkers to monitor the efficacy of a particular treatment....