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Quinzacara Sánchez, Ignacio (author)Addressing climate change is a challenge that governments, society, and companies have to face. For companies this becomes a major challenge as they are required to innovate in order to become more sustainable whilst still remain competitive. However, carrying out technological innovation may be useless if it cannot be diffused in the market....master thesis 2022
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Malubhoy, Zahabiya (author), Bahia, Frederico Mendonça (author), de Valk, Sophie Claire (author), de Hulster, A.F. (author), Rendulić, Toni (author), Ortiz, Juan Paulo Ragas (author), Xiberras, Joeline (author), Klein, Mathias (author), Mans, R. (author), Nevoigt, Elke (author)Background: The microbial production of succinic acid (SA) from renewable carbon sources via the reverse TCA (rTCA) pathway is a process potentially accompanied by net-fixation of carbon dioxide (CO<sub>2</sub>). Among reduced carbon sources, glycerol is particularly attractive since it allows a nearly twofold higher CO<sub>2</sub>-fixation...journal article 2022
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van Aalst, A.C.A. (author), Mans, R. (author), Pronk, J.T. (author)Background: Saccharomyces cerevisiae is intensively used for industrial ethanol production. Its native fermentation pathway enables a maximum product yield of 2 mol of ethanol per mole of glucose. Based on conservation laws, supply of additional electrons could support even higher ethanol yields. However, this option is disallowed by the...journal article 2022
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Rabah, Malek (author)Upcycling of the biomass residues and wastes is a necessary innovation within the given environmental and economic trends, policies and regulations, competition and depletion of natural resources taking place nowadays. Thus, wood pallet upcycling is chosen in this thesis to be the ambassador of biomass. <br/>Research is built upon the...master thesis 2021
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Liu, Y. (author)The progress of modern biotechnology has enabled the development of fermentation processes for the production of fuels and chemicals from renewable feedstocks. The current fermentation processes for bio-based production commonly start with a growth phase of the microorganisms followed by a production phase. This implies that biomass formation...doctoral thesis 2020
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Rombouts, J.L. (author)Microbial fermentations are a key process in naturally and man-made ecosystems. Microbial fermentations play a key role in creating and digesting our food and they are useful in designing bioprocesses that can produce biogas, biofuels, bioplastics, and many other functional molecules (Chapter 1). Furthermore, studying the competition and...doctoral thesis 2020
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Gorter de Vries, A.R. (author)Lager beer, also referred to as Pilsner, is the most popular alcoholic beverage in the world, with an annual consumption of almost 200 billion litres per year. To make lager beer, brewer’s wort is fermented with the yeast <i style="mso-bidi-font-style:normal"...doctoral thesis 2019
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Gomez Paez, Maria Paola (author)In the context of steering product formation in anaerobic digestion systems, the present thesis work elaborates on the potential role of elevated CO2 partial pressures as an environmental driver that may influence end-product selectivity from methane towards compounds from the carboxylic platform. As an emerging field of research, organic acid...master thesis 2019
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Papapetridis, I. (author), Goudriaan, M. (author), Vazquez Vitali, M. (author), De Keijzer, Nikita A. (author), van den Broek, M.A. (author), van Maris, A.J.A. (author), Pronk, J.T. (author)Background: Reduction or elimination of by-product formation is of immediate economic relevance in fermentation processes for industrial bioethanol production with the yeast Saccharomyces cerevisiae. Anaerobic cultures of wild-type S. cerevisiae require formation of glycerol to maintain the intracellular NADH/NAD<sup>+</sup> balance....journal article 2018
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Hendriks, A.T.W.M. (author), van Lier, J.B. (author), de Kreuk, M.K. (author)Fermentation and anaerobic digestion of organic waste and wastewater is broadly studied and applied. Despite widely available results and data for these processes, comparison of the generated results in literature is difficult. Not only due to the used variety of process conditions, but also because of the many different growth media that are...journal article 2018
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Haringa, C. (author), Mudde, R.F. (author), Noorman, H.J. (author)Euler–Lagrange computational fluid dynamics simulations offer great potential for the integration of transport dynamics and metabolic dynamics in fermentation systems. Since the seminal work of Lapin et al. [1,2], progress has been made, mainly in the analysis of CFD data and translation to laboratory setup designs. Different large-scale...journal article 2018
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Gorter de Vries, A.R. (author), Pronk, J.T. (author), Daran, J.G. (author)Chromosomal copy number variation (CCNV) plays a key role in evolution and health of eukaryotes. The unicellular yeast Saccharomyces cerevisiae is an important model for studying the generation, physiological impact, and evolutionary significance of CCNV. Fundamental studies of this yeast have contributed to an extensive set of methods for...journal article 2017
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Haringa, C. (author), Deshmukh, Amit T. (author), Mudde, R.F. (author), Noorman, H.J. (author)With reaction timescales equal to or shorter than the circulation time, the ideal mixing assumption typically does not hold for large scale bioreactors. As a consequence large scale gradients in extra-cellular conditions such as the substrate concentration exist, which may significantly impact the metabolism of micro-organisms and thereby the...journal article 2017
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Gaykawad, S.S. (author), Rütze, Dennis N. (author), van der Wielen, L.A.M. (author), Straathof, Adrie J.J. (author)In ethanol fermentations, about 2% of the ethanol leaves the fermenter with the off–gas. Conventionally, this is recovered by absorption in water. As alternative, vapour permeation was investigated conceptually for ethanol recovery from fermentation off–gas. A preliminary techno–economic evaluation of this system using hydrophobic membrane...journal article 2017
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Haringa, C. (author), Tang, Wenjun (author), Deshmukh, Amit T. (author), Xia, Jianye (author), Reuss, Matthias (author), Heijnen, J.J. (author), Noorman, H.J. (author), Mudde, R.F. (author)The trajectories, referred to as lifelines, of individual microorganisms in an industrial scale fermentor under substrate limiting conditions were studied using an Euler-Lagrange computational fluid dynamics approach. The metabolic response to substrate concentration variations along these lifelines provides deep insight in the dynamic...journal article 2016
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Sousa, João A.B. (author), Sorokin, Dimitry Y. (author), Bijmans, Martijn F.M. (author), Plugge, Caroline M. (author), Stams, Alfons J.M. (author)Haloalkaliphilic microorganisms that grow optimally at high-pH and high-salinity conditions can be found in natural environments such as soda lakes. These globally spread lakes harbour interesting anaerobic microorganisms that have the potential of being applied in existing technologies or create new opportunities. In this review, we discuss...review 2015
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Nijkamp, J.F. (author)Microorganisms are employed on a large scale in a variety of industrial production processes, such as production of food and ingredients, beverages, pharmaceutical compo- nents and fine- and bulk chemicals. Improving the behaviour of these microorganisms is of crucial importance in the design of efficient production processes. In this thesis we...doctoral thesis 2013
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Heerema, L.D. (author)In bioproduction processes of chemicals and pharmaceuticals, downstream processing usually is a significant cost factor. The products require a high purity (especially biopharmaceutical products), therefore, the process usually contains a large number of separation steps. Moreover, the high costs in downstream processing are caused by the fact...doctoral thesis 2012
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- Nie, J. (author), Solarte Vasquez, J.F. (author), Ucisik, M.H. (author), Yang, H. (author) report 2005