Modeling and Inference of Sparse Neural Dynamic Functional Connectivity Networks Underlying Functional Ultrasound Data

Functional ultrasound (fUS) is a novel neuroimaging technique that measures brain hemodynamics through a time series of Doppler images. The measured spatiotemporal hemodynamic changes reflect changes in neural activity through the neurovascular coupling (NVC). Often, such image time series is used to analyze dynamic functional connectivity ...

Analyzing dynamic functional connectivity using state-space models on mice fUS data

In recent years, the increase in brain research led to the development of large-scale brain imaging techniques. With large-scale brain imaging techniques, such as functional magnetic resonance imaging (fMRI), functional connectivity analyses have shown altered connectivity patterns in humans and mice with neurobiological disorders, such as...

Resting-State Functional Networks Correlate with Motor Performance in a Complex Visuomotor Task: An EEG Microstate Pilot Study on Healthy Individuals

Developing motor and cognitive skills is needed to achieve expert (motor) performance or functional recovery from a neurological condition, e.g., after stroke. While extensive practice plays an essential role in the acquisition of good motor performance, it is still unknown whether certain person-specific traits may predetermine the rate of...

Predicting time-resolved electrophysiological brain networks from structural eigenmodes

How temporal modulations in functional interactions are shaped by the underlying anatomical connections remains an open question. Here, we analyse the role of structural eigenmodes, in the formation and dissolution of temporally evolving functional brain networks using resting-state magnetoencephalography and diffusion magnetic resonance...

Patterns of functional connectivity in an aging population: The Rotterdam Study

Structural brain markers are studied extensively in the field of neurodegeneration, but are thought to occur rather late in the process. Functional measures such as functional connectivity are gaining interest as potentially more subtle markers of neurodegeneration. However, brain structure and function are also affected by ‘normal’ brain...

Applying the epidemic spreading model on the brain network to explain effective connectivity

Network science studies a complex system as a network to capture the connectivity patterns and topological features. Different network topologies have been observed to shape dynamic spread- ing processes on the network in various ways, while the exact relationship is complicated and not yet fully understood. Epidemic models are often applied to...

Predicting haemodynamic networks using electrophysiology: The role of non-linear and cross-frequency interactions

Understanding the electrophysiological basis of resting state networks (RSNs) in the human brain is a critical step towards elucidating how inter-areal connectivity supports healthy brain function. In recent years, the relationship between RSNs (typically measured using haemodynamic signals) and electrophysiology has been explored using...

Dynamic functional brain connectivity for face perception

The Union of Shortest Path Trees of Functional Brain Networks

Communication between brain regions is still insufficiently understood. Applying concepts from network science has shown to be successful in gaining insight in the functioning of the brain. Recent work has implicated that especially shortest paths in the structural brain network seem to play a major role in the communication within the brain. So...

The Trees and the Forest: Characterization of complex brain networks with minimum spanning trees

In recent years there has been a shift in focus from the study of local, mostly task-related activation to the exploration of the organization and functioning of large-scale structural and functional complex brain networks. Progress in the interdisciplinary field of modern network science has introduced many new concepts, analytical tools and...

Disruption of Functional Brain Networks in Alzheimer’s Disease: What Can We Learn from Graph Spectral Analysis of Resting-State Magnetoencephalography?

In Alzheimer’s disease (AD), structural and functional brain network organization is disturbed. However, many of the present network analysis measures require a priori assumptions and methodological choices that influence outcomes and interpretations. Graph spectral analysis (GSA) is a more direct algebraic method that describes network...