Evaluation of natural language processing embeddings in protein function prediction for bacteria

<b>Motivation: </b>The development of automated protein function prediction models is essential in closing the gap between the large amount of protein sequence data available and the fraction of validly annotated data. Recent approaches to function prediction rely on unsupervised deep learning models, through which protein sequences are...

What does that gene do?: Gene function prediction by machine learning with applications to plants

Billions of people world-wide rely on plant-based food for their daily energy intake. As global warming and the spread of diseases (such as the banana Panama disease) is substantially hindering the cultivation of plants, the need to develop temperature- and/or disease-resistant varieties is getting more and more pressing. The field of plant...

The Power of Universal Contextualized Protein Embeddings in Cross-species Protein Function Prediction

Computationally annotating proteins with a molecular function is a difficult problem that is made even harder due to the limited amount of available labeled protein training data. Unsupervised protein embeddings partly circumvent this limitation by learning a universal protein representation from many unlabeled sequences. Such embeddings...

Thermal energy recovery from chlorinated drinking water distribution systems: Effect on chlorine and microbial water and biofilm characteristics

Thermal energy recovery from drinking water has a high potential in the application of sustainable building and industrial cooling. However, drinking water and biofilm microbial qualities should be concerned because the elevated water temperature after cold recovery may influence the microbial activities in water and biofilm phases in drinking...

Automatic gene function prediction in the 2020’s

The current rate at which new DNA and protein sequences are being generated is too fast to experimentally discover the functions of those sequences, emphasizing the need for accurate Automatic Function Prediction (AFP) methods. AFP has been an active and growing research field for decades and has made considerable progress in that time....