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Hashemi, A. (author)In this thesis, I highlighted a number of projects aimed at developing and testing new simulation methods for studying complex reactive systems, with a particular emphasis on simulation strategies based on the concept of bonding graphs. These mathematical structures provide useful tools for a variety of algorithms developed over the last few...doctoral thesis 2023
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Postma, J.I. (author), Ferrari, A. (author), Bottger, A.J. (author)Surface compositions play a predominant role in the efficiency and lifetime of membranes and catalysts. The surface composition can change during operation due to segregation, thus controlling and predicting the surface composition is essential. Computational modelling can aid in predicting alloy stability, along with designing surface alloys...journal article 2023
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Abbassi-Daloii, Tooba (author), el Abdellaoui, Salma (author), Kan, H.E. (author), van den Akker, E.B. (author), ’t Hoen, Peter A.C. (author), Raz, Vered (author), Voortman, Lenard M. (author)Skeletal muscles are composed of different myofiber types characterized by the expression of myosin heavy chain isoforms, which can be affected by physical activity, aging, and pathological conditions. Here, we present a step-by-step high-throughput semi-automated approach for performing myofiber type quantification of entire human or mouse...journal article 2023
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Wang, Feifei (author), Pan, Jiazheng (author), Hu, Yulin (author), Zhou, Jie (author), Wang, Haoqian (author), Huang, Xin (author), Chu, Wenhai (author), van der Hoek, J.P. (author)Biological activated carbon (BAC) filtration is usually considered to be able to decrease formation potentials (FPs) of disinfection by-products (DBPs) in drinking water treatment plant (DWTP). However, BAC filters with long running time may release microbial metabolites to effluents and therefore increase FPs of nitrogenous DBPs with high...journal article 2022
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Keulen, D. (author), Geldhof, Geoffroy (author), Bussy, Olivier Le (author), Pabst, Martin (author), Ottens, M. (author)The safety requirements for vaccines are extremely high since they are administered to healthy people. For that reason, vaccine development is time-consuming and very expensive. Reducing time-to-market is key for pharmaceutical companies, saving lives and money. Therefore the need is raised for systematic, general and efficient process...journal article 2022
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Severins, I.W.H. (author), Joo, C. (author), van Noort, John (author)Next-generation sequencing techniques have led to a new quantitative dimension in the biological sciences. In particular, integrating sequencing techniques with biophysical tools allows sequence-dependent mechanistic studies. Using the millions of DNA clusters that are generated during sequencing to perform high-throughput binding affinity...review 2022
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Picanço Castanheira Da Silva, T. (author), Eppink, Michel (author), Ottens, M. (author)Biopharmaceuticals are becoming increasingly important in modern healthcare. Monoclonal antibodies (mAb) are one of the most widely used therapeutic proteins and are important for the treatment of cancer and autoimmune diseases, among others. After cell culture there are still large amounts of other impurities (e.g. host cell proteins) in...journal article 2022
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Barrios, Alan J. (author), Peron, Deizi V. (author), Chakkingal, Anoop (author), Dugulan, A.I. (author), Moldovan, Simona (author), Nakouri, Kalthoum (author), Thuriot-Roukos, Joëlle (author), Wojcieszak, Robert (author), Thybaut, Joris W. (author)Hydrogenation into light olefins is an attractive strategy for CO<sub>2</sub>fixation into chemicals. In this article, high throughput experimentation and extended characterization were employed to identify the most efficient promoters and to elucidate structure-performance correlations and reaction paths in the CO<sub>2</sub>hydrogenation to...journal article 2022
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FLOROS, Theofanis (author)Current high-end medical X-ray intervention devices provide a tremendous amount of high-definition images per second. Combined with the additional inputs from the numerous auxiliary devices, processing and compositing the data in real-time quickly becomes an arduous engineering challenge. Furthermore, the critical nature of this application...master thesis 2021
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Antoniadis, Gregory (author)Ammonia is an important chemical used in the production of fertilizers and has the potential to become a green energy carrier. It is synthesized through the Haber-Bosch (HB) process, which involves nitrogen and hydrogen reacting at high temperature and pressure and consumes approximately 2% of the global energy supply. An alternative to this...master thesis 2021
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van Schendel, R.K.A. (author), Yang, W. (author), Uslamin, E. (author), Pidko, E.A. (author)Homogeneous hydrogenation catalysts based on metal complexes provide a diverse and highly tunable tool for the fine chemical industry. To fully unleash their potential, fast and effective methods for the evaluation of catalytic properties are needed. In turn, this requires changes in the experimental approaches to test and evaluate the...journal article 2021
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Seifert, Mona (author), Bera, Subhas C. (author), van Nies, Pauline (author), Kirchdoerfer, Robert N. (author), Shannon, Ashleigh (author), Le, Thi Tuyet Nhung (author), Meng, Xiangzhi (author), Depken, S.M. (author), Dulin, David (author)The absence of 'shovel-ready' anti-coronavirus drugs during vaccine development has exceedingly worsened the SARS-CoV-2 pandemic. Furthermore, new vaccine-resistant variants and coronavirus outbreaks may occur in the near future, and we must be ready to face this possibility. However, efficient antiviral drugs are still lacking to this day,...journal article 2021
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Bera, Subhas Chandra (author), Seifert, Mona (author), Kirchdoerfer, Robert N. (author), van Nies, Pauline (author), Wubulikasimu, Yibulayin (author), Quack, Salina (author), Papini, Flávia S. (author), Depken, S.M. (author), Dulin, D. (author)Coronaviruses have evolved elaborate multisubunit machines to replicate and transcribe their genomes. Central to these machines are the RNA-dependent RNA polymerase subunit (nsp12) and its intimately associated cofactors (nsp7 and nsp8). We use a high-throughput magnetic-tweezers approach to develop a mechanochemical description of this core...journal article 2021
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Moreno Gonzalez, M. (author), Chuekitkumchorn, Pattra (author), Silva, Marcelo (author), Groenewoud, Roos (author), Ottens, M. (author)Proteins derived from plant resources such as oilseed meals, canola and sunflower, are considered a viable alternative to animal proteins for food consumption. This work presents a rational methodology, using high throughput experimentation (HTE), for the separation of cruciferin and napin, the two major proteins of canola meal, by...journal article 2021
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Lane, R. (author), Vos, Y. (author), Wolters, A.E. (author), van Kessel, L.C.P.M. (author), Chen, S. Elisa (author), Liv, Nalan (author), Klumperman, Judith (author), Giepmans, Ben N.G. (author), Hoogenboom, J.P. (author)Large-scale electron microscopy (EM) allows analysis of both tissues and macromolecules in a semi-automated manner, but acquisition rate forms a bottleneck. We reasoned that a negative bias potential may be used to enhance signal collection, allowing shorter dwell times and thus increasing imaging speed. Negative bias potential has previously...journal article 2021
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Neves Sao Pedro, M. (author), Picanço Castanheira Da Silva, T. (author), Patil, Rohan (author), Ottens, M. (author)Continuous manufacturing is an indicator of a maturing industry, as can be seen by the example of the petrochemical industry. Patent expiry promotes a price competition between manufacturing companies, and more efficient and cheaper processes are needed to achieve lower production costs. Over the last decade, continuous biomanufacturing has...journal article 2021
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Klijn, M.E. (author), Hubbuch, Juergen (author)Imaging is increasingly more utilized as analytical technology in biopharmaceutical formulation research, with applications ranging from subvisible particle characterization to thermal stability screening and residual moisture analysis. This review offers a comprehensive overview of analytical imaging for scientists active in...journal article 2021
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Picanço Castanheira Da Silva, T. (author), Eppink, Michel (author), Ottens, M. (author)Process development in the biotech industry leads to investments around hundred of millions of dollars. It is important to mitigate costs without neglecting the quality of process development. Biopharmaceutical process development is important for companies to develop new processes and be first to market, improve a pre-established process, or...review 2021
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- Schutte, M.W. (author) bachelor thesis 2020
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Rho, Hoon Suk (author), Veltkamp, Henk Willem (author), Hanke, A.T. (author), Ottens, M. (author), Breukers, Christian (author), Habibović, Pamela (author), Gardeniers, Han (author)A microfluidic protein aggregation device (microPAD) that allows the user to perform a series of protein incubations with various concentrations of two reagents is demonstrated. The microfluidic device consists of 64 incubation chambers to perform individual incubations of the protein at 64 specific conditions. Parallel processes of metering...journal article 2020
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