Searched for: subject%3A%22Image%22
(1 - 16 of 16)
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Somarakis, Antonios (author), van Unen, Vincent (author), Koning, Frits (author), Lelieveldt, B.P.F. (author), Höllt, T. (author)
Tissue functionality is determined by the characteristics of tissue-resident cells and their interactions within their microenvironment. Imaging Mass Cytometry offers the opportunity to distinguish cell types with high precision and link them to their spatial location in intact tissues at sub-cellular resolution. This technology produces large...
journal article 2021
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Sokooti, Hessam (author), Yousefi, Sahar (author), Elmahdy, Mohamed S. (author), Lelieveldt, B.P.F. (author), Staring, M. (author)
In this paper we propose a supervised method to predict registration misalignment using convolutional neural networks (CNNs). This task is casted to a classification problem with multiple classes of misalignment: 'correct' 0-3 mm, 'poor' 3-6 mm and 'wrong' over 6 mm. Rather than a direct prediction, we propose a hierarchical approach, where...
journal article 2021
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Ijsselsteijn, Marieke E. (author), Somarakis, Antonios (author), Lelieveldt, B.P.F. (author), Höllt, T. (author), de Miranda, Noel F. C. C. (author)
Imaging mass cytometry (IMC) allows the detection of multiple antigens (approximately 40 markers) combined with spatial information, making it a unique tool for the evaluation of complex biological systems. Due to its widespread availability and retained tissue morphology, formalin-fixed, paraffin-embedded (FFPE) tissues are often a material...
journal article 2021
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Somarakis, Antonios (author), Ijsselsteijn, Marieke E. (author), Luk, Sietse J. (author), Kenkhuis, Boyd (author), de Miranda, Noel F. C. C. (author), Lelieveldt, B.P.F. (author), Höllt, T. (author)
Spatially-resolved omics-data enable researchers to precisely distinguish cell types in tissue and explore their spatial interactions, enabling deep understanding of tissue functionality. To understand what causes or deteriorates a disease and identify related biomarkers, clinical researchers regularly perform large-scale cohort studies,...
journal article 2021
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Pezzotti, Nicola (author), Yousefi, Sahar (author), Elmahdy, Mohamed S. (author), van Gemert, Jeroen Hendrikus Fransiscus (author), Schuelke, Christophe (author), Doneva, Mariya (author), Nielsen, Tim (author), Lelieveldt, B.P.F. (author), Staring, M. (author)
Adaptive intelligence aims at empowering machine learning techniques with the additional use of domain knowledge. In this work, we present the application of adaptive intelligence to accelerate MR acquisition. Starting from undersampled k-space data, an iterative learning-based reconstruction scheme inspired by compressed sensing theory is...
journal article 2020
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Qiao, Yuchuan (author), Jagt, Thyrza (author), Hoogeman, M.S. (author), Lelieveldt, B.P.F. (author), Staring, M. (author)
Objective: Our goal was to investigate the performance of an open source deformable image registration package, elastix, for fast and robust contour propagation in the context of online-adaptive intensity-modulated proton therapy (IMPT) for prostate cancer. Methods: A planning and 7–10 repeat CT scans were available of 18 prostate cancer...
journal article 2019
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Li, Na (author), van Unen, Vincent (author), Guo, Nannan (author), Abdelaal, T.R.M. (author), Somarakis, Antonios (author), Eggermont, Jeroen (author), Mahfouz, A.M.E.T.A. (author), Chuva de Sousa Lopes, Susana M. (author), Lelieveldt, B.P.F. (author), Koning, Frits (author)
The human fetal immune system must protect the infant against the sudden exposure to a large variety of pathogens upon birth. While it is known that the fetal immune system develops in sequential waves, relatively little is known about the composition of the innate and adaptive immune system in the tissues. Here, we applied high-dimensional...
journal article 2019
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Shahzad, Rahil (author), Shankar, Arun (author), Amier, Raquel (author), Nijveldt, Robin (author), Westenberg, Jos J.M. (author), de Roos, Albert (author), Lelieveldt, B.P.F. (author), van der Geest, R.J. (author)
Background: Aortic pulse wave velocity (PWV) is an indicator of aortic stiffness and is used as a predictor of adverse cardiovascular events. PWV can be non-invasively assessed using magnetic resonance imaging (MRI). PWV computation requires two components, the length of the aortic arch and the time taken for the systolic pressure wave to...
journal article 2019
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Liu, Shengnan (author), Dzyubachyk, Oleh (author), Eggermont, Jeroen (author), Nakatani, Shimpei (author), Lelieveldt, B.P.F. (author), Dijkstra, J. (author)
Purpose: Intravascular optical coherence tomography (OCT) is widely used for analysis of the coronary artery disease. Its high spatial resolution allows for visualization of arterial tissue components in detail. There are different OCT systems on the market, each of which produces data characterized by its own intensity range and distribution...
journal article 2018
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Mahfouz, A.M.E.T.A. (author), Huisman, S.M.H. (author), Lelieveldt, B.P.F. (author), Reinders, M.J.T. (author)
The immense complexity of the mammalian brain is largely reflected in the underlying molecular signatures of its billions of cells. Brain transcriptome atlases provide valuable insights into gene expression patterns across different brain areas throughout the course of development. Such atlases allow researchers to probe the molecular mechanisms...
journal article 2017
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Aizenberg, Evgeni (author), van den Berg, Rosaline (author), Ez-Zaitouni, Zineb (author), van der Heijde, Désirée (author), Reijnierse, Monique (author), Dzyubachyk, Oleh (author), Lelieveldt, B.P.F. (author)
Background: Evaluating inflammatory changes over time on MR images of the spine in patients with suspected axial Spondyloarthritis (axSpA) can be a labor-intensive task, requiring readers to manually search for and perceptually align a set of vertebrae between two scans. The purpose of this study was to assess the feasibility of computer...
journal article 2017
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Shamonin, D.P. (author), Bron, E.E. (author), Lelieveldt, B.P.F. (author), Smits, M. (author), Klein, S. (author), Staring, M. (author)
Nonrigid image registration is an important, but time-consuming task in medical image analysis. In typical neuroimaging studies, multiple image registrations are performed, i.e., for atlas-based segmentation or template construction. Faster image registration routines would therefore be beneficial. In this paper we explore acceleration of the...
journal article 2014
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Kirisli, H.A. (author), Gupta, V. (author), Kirschbaum, S. (author), Neefjes, L. (author), Van Geuns, R.J. (author), Mollet, N. (author), Lelieveldt, B.P.F. (author), Reiber, J.H.C. (author), Van Walsum, T. (author), Niessen, W.J. (author)
Cardiac magnetic resonance perfusion imaging (CMR) and computed tomography angiography (CTA) are widely used to assess heart disease. CMR is used to measure the global and regional myocardial function and to evaluate the presence of ischemia; CTA is used for diagnosing coronary artery disease, such as coronary stenoses. Nowadays, the hemodynamic...
conference paper 2011
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Kok, P. (author), Baiker, M. (author), Hendriks, E.A. (author), Post, F.H. (author), Dijkstra, J. (author), Löwik, C.W.G.M. (author), Lelieveldt, B.P.F. (author), Botha, C.P. (author)
The analysis of multi-timepoint whole-body small animal CT data is greatly complicated by the varying posture of the subject at different timepoints. Due to these variations, correctly relating and comparing corresponding regions of interest is challenging. In addition, occlusion may prevent effective visualization of these regions of interest....
journal article 2010
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Khmelinskii, A. (author), Baiker, M. (author), Kaijzel, E.L. (author), Chen, J. (author), Reiber, J.H.C. (author), Lelieveldt, B.P.F. (author)
Purpose Using three publicly available small-animal atlases (Sprague–Dawley rat, MOBY, and Digimouse), we built three articulated atlases and present several applications in the scope of molecular imaging. Procedures Major bones/bone groups were manually segmented for each atlas skeleton. Then, a kinematic model for each atlas was built: each...
journal article 2010
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Kok, P. (author), Dijkstra, J. (author), Botha, C.P. (author), Post, F.H. (author), Kaijzel, E. (author), Que, I. (author), Löwik, C.W.G.M. (author), Reiber, J.H.C. (author), Lelieveldt, B.P.F. (author)
This paper explores new methods to visualize and fuse multi-2D bioluminescence imaging (BLI) data with structural imaging modalities such as micro CT and MR. A geometric, back-projection-based 3D reconstruction for superficial lesions from multi-2D BLI data is presented, enabling a coarse estimate of the 3D source envelopes from the multi-2D BLI...
conference paper 2007
Searched for: subject%3A%22Image%22
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